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Anti-CALCR/ CRT/ CT-R monoclonal antibody
Anti-CALCR/ CRT/ CT-R antibody for FACS & in-vivo assay
Go to CALCR/CALCR products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T32247-Ab-1/ GM-Tg-hg-T32247-Ab-2 | Anti-Human CALCR monoclonal antibody | Human |
| GM-Tg-rg-T32247-Ab-1/ GM-Tg-rg-T32247-Ab-2 | Anti-Rat CALCR monoclonal antibody | Rat |
| GM-Tg-mg-T32247-Ab-1/ GM-Tg-mg-T32247-Ab-2 | Anti-Mouse CALCR monoclonal antibody | Mouse |
| GM-Tg-cynog-T32247-Ab-1/ GM-Tg-cynog-T32247-Ab-2 | Anti-Cynomolgus/ Rhesus macaque CALCR monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T32247-Ab-1/ GM-Tg-felg-T32247-Ab-2 | Anti-Feline CALCR monoclonal antibody | Feline |
| GM-Tg-cang-T32247-Ab-1/ GM-Tg-cang-T32247-Ab-2 | Anti-Canine CALCR monoclonal antibody | Canine |
| GM-Tg-bovg-T32247-Ab-1/ GM-Tg-bovg-T32247-Ab-2 | Anti-Bovine CALCR monoclonal antibody | Bovine |
| GM-Tg-equg-T32247-Ab-1/ GM-Tg-equg-T32247-Ab-2 | Anti-Equine CALCR monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T32247-Ab-1/ GM-Tg-hg-T32247-Ab-2; GM-Tg-rg-T32247-Ab-1/ GM-Tg-rg-T32247-Ab-2; GM-Tg-mg-T32247-Ab-1/ GM-Tg-mg-T32247-Ab-2; GM-Tg-cynog-T32247-Ab-1/ GM-Tg-cynog-T32247-Ab-2; GM-Tg-felg-T32247-Ab-1/ GM-Tg-felg-T32247-Ab-2; GM-Tg-cang-T32247-Ab-1/ GM-Tg-cang-T32247-Ab-2; GM-Tg-bovg-T32247-Ab-1/ GM-Tg-bovg-T32247-Ab-2; GM-Tg-equg-T32247-Ab-1/ GM-Tg-equg-T32247-Ab-2 |
| Products Name | Anti-CALCR monoclonal antibody |
| Format | mab |
| Target Name | CALCR |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-CALCR benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species CALCR/ CRT/ CT-R VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | vGMLP002726 | human CALCR Lentivirus particle |
| ORF Viral Vector | pGMLP002726 | human CALCR Lentivirus plasmid |
Target information
| Target ID | GM-T32247 |
| Target Name | CALCR |
| Gene ID | 799,12311,116506,701093,482306,101087825,613317,100061915 |
| Gene Symbol and Synonyms | CALCR,Clr,CRT,CT-R,CTR,CTR1 |
| Uniprot Accession | P30988,P32214 |
| Uniprot Entry Name | CALCR_HUMAN,CALCR_RAT |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000004948 |
| Target Classification | N/A |
The target: CALCR, gene name: CALCR, also named as CRT, CT-R, CTR, CTR1. This gene encodes a high affinity receptor for the peptide hormone calcitonin and belongs to a subfamily of seven transmembrane-spanning G protein-coupled receptors. The encoded protein is involved in maintaining calcium homeostasis and in regulating osteoclast-mediated bone resorption. Polymorphisms in this gene have been associated with variations in bone mineral density and onset of osteoporosis. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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