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Anti-MAS/ MAS1/ MGRA monoclonal antibody
Anti-MAS/ MAS1/ MGRA antibody for FACS & in-vivo assay
Go to MAS1/MAS1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T33318-Ab-1/ GM-Tg-hg-T33318-Ab-2 | Anti-Human MAS1 monoclonal antibody | Human |
| GM-Tg-rg-T33318-Ab-1/ GM-Tg-rg-T33318-Ab-2 | Anti-Rat MAS1 monoclonal antibody | Rat |
| GM-Tg-mg-T33318-Ab-1/ GM-Tg-mg-T33318-Ab-2 | Anti-Mouse MAS1 monoclonal antibody | Mouse |
| GM-Tg-cynog-T33318-Ab-1/ GM-Tg-cynog-T33318-Ab-2 | Anti-Cynomolgus/ Rhesus macaque MAS1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T33318-Ab-1/ GM-Tg-felg-T33318-Ab-2 | Anti-Feline MAS1 monoclonal antibody | Feline |
| GM-Tg-cang-T33318-Ab-1/ GM-Tg-cang-T33318-Ab-2 | Anti-Canine MAS1 monoclonal antibody | Canine |
| GM-Tg-bovg-T33318-Ab-1/ GM-Tg-bovg-T33318-Ab-2 | Anti-Bovine MAS1 monoclonal antibody | Bovine |
| GM-Tg-equg-T33318-Ab-1/ GM-Tg-equg-T33318-Ab-2 | Anti-Equine MAS1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T33318-Ab-1/ GM-Tg-hg-T33318-Ab-2; GM-Tg-rg-T33318-Ab-1/ GM-Tg-rg-T33318-Ab-2; GM-Tg-mg-T33318-Ab-1/ GM-Tg-mg-T33318-Ab-2; GM-Tg-cynog-T33318-Ab-1/ GM-Tg-cynog-T33318-Ab-2; GM-Tg-felg-T33318-Ab-1/ GM-Tg-felg-T33318-Ab-2; GM-Tg-cang-T33318-Ab-1/ GM-Tg-cang-T33318-Ab-2; GM-Tg-bovg-T33318-Ab-1/ GM-Tg-bovg-T33318-Ab-2; GM-Tg-equg-T33318-Ab-1/ GM-Tg-equg-T33318-Ab-2 |
| Products Name | Anti-MAS1 monoclonal antibody |
| Format | mab |
| Target Name | MAS1 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-MAS1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species MAS/ MAS1/ MGRA VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | pGMLP003192 | human MAS1 Lentivirus plasmid |
| ORF Viral Vector | vGMLP003192 | human MAS1 Lentivirus particle |
| ORF Viral Vector | pGMAD000212 | mouse Mas1 Adenovirus plasmid |
| ORF Viral Vector | vGMAD000212 | mouse Mas1 Adenovirus particle |
Target information
| Target ID | GM-T33318 |
| Target Name | MAS1 |
| Gene ID | 4142,17171,25153,703105,484066,101094352,783010,111771416 |
| Gene Symbol and Synonyms | c-mas,MAS,Mas-1,MAS1,MasR,MGRA |
| Uniprot Accession | P04201,P12526 |
| Uniprot Entry Name | MAS_HUMAN,MAS_RAT |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target |
| Disease | Cancer |
| Gene Ensembl | ENSG00000130368 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: MAS1, gene name: MAS1, also named as MAS, MGRA. This gene encodes a class I seven-transmembrane G-protein-coupled receptor. The encoded protein is a receptor for angiotensin-(1-7) and preferentially couples to the Gq protein, activating the phospholipase C signaling pathway. The encoded protein may play a role in multiple processes including hypotension, smooth muscle relaxation and cardioprotection by mediating the effects of angiotensin-(1-7). [provided by RefSeq, May 2012].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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