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Anti-GRIA1/ GLUH1/ GLUR1 monoclonal antibody
Anti-GRIA1/ GLUH1/ GLUR1 antibody for FACS & in-vivo assay
Go to GRIA1/GRIA1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T33584-Ab-1/ GM-Tg-hg-T33584-Ab-2 | Anti-Human GRIA1 monoclonal antibody | Human |
| GM-Tg-rg-T33584-Ab-1/ GM-Tg-rg-T33584-Ab-2 | Anti-Rat GRIA1 monoclonal antibody | Rat |
| GM-Tg-mg-T33584-Ab-1/ GM-Tg-mg-T33584-Ab-2 | Anti-Mouse GRIA1 monoclonal antibody | Mouse |
| GM-Tg-cynog-T33584-Ab-1/ GM-Tg-cynog-T33584-Ab-2 | Anti-Cynomolgus/ Rhesus macaque GRIA1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T33584-Ab-1/ GM-Tg-felg-T33584-Ab-2 | Anti-Feline GRIA1 monoclonal antibody | Feline |
| GM-Tg-cang-T33584-Ab-1/ GM-Tg-cang-T33584-Ab-2 | Anti-Canine GRIA1 monoclonal antibody | Canine |
| GM-Tg-bovg-T33584-Ab-1/ GM-Tg-bovg-T33584-Ab-2 | Anti-Bovine GRIA1 monoclonal antibody | Bovine |
| GM-Tg-equg-T33584-Ab-1/ GM-Tg-equg-T33584-Ab-2 | Anti-Equine GRIA1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T33584-Ab-1/ GM-Tg-hg-T33584-Ab-2; GM-Tg-rg-T33584-Ab-1/ GM-Tg-rg-T33584-Ab-2; GM-Tg-mg-T33584-Ab-1/ GM-Tg-mg-T33584-Ab-2; GM-Tg-cynog-T33584-Ab-1/ GM-Tg-cynog-T33584-Ab-2; GM-Tg-felg-T33584-Ab-1/ GM-Tg-felg-T33584-Ab-2; GM-Tg-cang-T33584-Ab-1/ GM-Tg-cang-T33584-Ab-2; GM-Tg-bovg-T33584-Ab-1/ GM-Tg-bovg-T33584-Ab-2; GM-Tg-equg-T33584-Ab-1/ GM-Tg-equg-T33584-Ab-2 |
| Products Name | Anti-GRIA1 monoclonal antibody |
| Format | mab |
| Target Name | GRIA1 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-GRIA1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species GRIA1/ GLUH1/ GLUR1 VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | pGMLPm004794 | mouse Gria1 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm004794 | mouse Gria1 Lentivirus particle |
Target information
| Target ID | GM-T33584 |
| Target Name | GRIA1 |
| Gene ID | 2890,14799,50592,714117,489168,101097621,529618,100060020 |
| Gene Symbol and Synonyms | 2900051M01Rik,Glr-1,Glr1,GluA1,GLUH1,Glur-1,GluR-A,gluR-K1,GLUR1,GLURA,GRIA1,HBGR1,HIPA1,MRD67,MRT76 |
| Uniprot Accession | P42261,P19490 |
| Uniprot Entry Name | GRIA1_HUMAN,GRIA1_RAT |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000155511 |
| Target Classification | N/A |
The target: GRIA1, gene name: GRIA1, also named as GLUH1, GLUR1, GLURA, GluA1, HBGR1. Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. This gene belongs to a family of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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