Anti-SCNBA/ SCN11A/ FEPS3 monoclonal antibody
Anti-SCNBA/ SCN11A/ FEPS3 antibody for FACS & in-vivo assay
Go to SCN11A/SCN11A products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
Product information
Catalog No. | Product Name | Species Reactivity |
---|---|---|
GM-Tg-hg-T34123-Ab-1/ GM-Tg-hg-T34123-Ab-2 | Anti-Human SCN11A monoclonal antibody | Human |
GM-Tg-rg-T34123-Ab-1/ GM-Tg-rg-T34123-Ab-2 | Anti-Rat SCN11A monoclonal antibody | Rat |
GM-Tg-mg-T34123-Ab-1/ GM-Tg-mg-T34123-Ab-2 | Anti-Mouse SCN11A monoclonal antibody | Mouse |
GM-Tg-cynog-T34123-Ab-1/ GM-Tg-cynog-T34123-Ab-2 | Anti-Cynomolgus/ Rhesus macaque SCN11A monoclonal antibody | Cynomolgus/ Rhesus macaque |
GM-Tg-felg-T34123-Ab-1/ GM-Tg-felg-T34123-Ab-2 | Anti-Feline SCN11A monoclonal antibody | Feline |
GM-Tg-cang-T34123-Ab-1/ GM-Tg-cang-T34123-Ab-2 | Anti-Canine SCN11A monoclonal antibody | Canine |
GM-Tg-bovg-T34123-Ab-1/ GM-Tg-bovg-T34123-Ab-2 | Anti-Bovine SCN11A monoclonal antibody | Bovine |
GM-Tg-equg-T34123-Ab-1/ GM-Tg-equg-T34123-Ab-2 | Anti-Equine SCN11A monoclonal antibody | Equine |
Size: 1mg | 10mg | 100mg
Product Description
Catalog No. | GM-Tg-hg-T34123-Ab-1/ GM-Tg-hg-T34123-Ab-2; GM-Tg-rg-T34123-Ab-1/ GM-Tg-rg-T34123-Ab-2; GM-Tg-mg-T34123-Ab-1/ GM-Tg-mg-T34123-Ab-2; GM-Tg-cynog-T34123-Ab-1/ GM-Tg-cynog-T34123-Ab-2; GM-Tg-felg-T34123-Ab-1/ GM-Tg-felg-T34123-Ab-2; GM-Tg-cang-T34123-Ab-1/ GM-Tg-cang-T34123-Ab-2; GM-Tg-bovg-T34123-Ab-1/ GM-Tg-bovg-T34123-Ab-2; GM-Tg-equg-T34123-Ab-1/ GM-Tg-equg-T34123-Ab-2 |
Products Name | Anti-SCN11A monoclonal antibody |
Format | mab |
Target Name | SCN11A |
Protein Sub-location | Transmembrane Protein |
Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
Derivation (species) | Mouse |
CH1+2+3 Isotype (Receptor identification) | IgG |
Type of Light Chain (VD-LC) | N/A |
Expression platform | Mammalian Expression |
Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
Tag | Fc |
Products description | Pre-made anti-SCN11A benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
Purity | Purity: ≥95% (SDS-PAGE) |
Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
Category | Cat No. | Products Name |
Target Antigen | Products Developing | Multi-species SCNBA/ SCN11A/ FEPS3 VLP (virus-like particle) (Products Developing) |
Target information
Target ID | GM-T34123 |
Target Name | SCN11A |
Gene ID | 11280,24046,29701,695258,485593,101085312,535956,100068480 |
Gene Symbol and Synonyms | FEPS3,HSAN7,NaN,NaT,NAV1.9,NSS2,PN5,SCN11A,SCN12A,SNS-2,SNS2 |
Uniprot Accession | Q9UI33,O88457 |
Uniprot Entry Name | SCNBA_HUMAN,SCNBA_RAT |
Protein Sub-location | Transmembrane Protein |
Category | Therapeutics Target |
Disease | N/A |
Gene Ensembl | ENSG00000168356 |
Target Classification | N/A |
The target: SCN11A, gene name: SCN11A, also named as FEPS3, HSAN7, NAV1.9, NaN, PN5, SCN12A, SNS-2. Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit with 24 transmembrane domains and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel alpha subunit gene family, and is highly expressed in nociceptive neurons of dorsal root ganglia and trigeminal ganglia. It mediates brain-derived neurotrophic factor-evoked membrane depolarization and is a major effector of peripheral inflammatory pain hypersensitivity. Mutations in this gene have been associated with hereditary sensory and autonomic neuropathy type VII and familial episodic pain syndrome-3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2017].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.