Anti-ITAL/ ITGAL/ CD11A monoclonal antibody

Anti-ITAL/ ITGAL/ CD11A antibody for FACS & in-vivo assay

Target products collectionGo to ITGAL/ITGAL products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T35640-Ab-1/ GM-Tg-hg-T35640-Ab-2Anti-Human ITGAL monoclonal antibodyHuman
GM-Tg-rg-T35640-Ab-1/ GM-Tg-rg-T35640-Ab-2Anti-Rat ITGAL monoclonal antibodyRat
GM-Tg-mg-T35640-Ab-1/ GM-Tg-mg-T35640-Ab-2Anti-Mouse ITGAL monoclonal antibodyMouse
GM-Tg-cynog-T35640-Ab-1/ GM-Tg-cynog-T35640-Ab-2Anti-Cynomolgus/ Rhesus macaque ITGAL monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T35640-Ab-1/ GM-Tg-felg-T35640-Ab-2Anti-Feline ITGAL monoclonal antibodyFeline
GM-Tg-cang-T35640-Ab-1/ GM-Tg-cang-T35640-Ab-2Anti-Canine ITGAL monoclonal antibodyCanine
GM-Tg-bovg-T35640-Ab-1/ GM-Tg-bovg-T35640-Ab-2Anti-Bovine ITGAL monoclonal antibodyBovine
GM-Tg-equg-T35640-Ab-1/ GM-Tg-equg-T35640-Ab-2Anti-Equine ITGAL monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T35640-Ab-1/ GM-Tg-hg-T35640-Ab-2; GM-Tg-rg-T35640-Ab-1/ GM-Tg-rg-T35640-Ab-2;
GM-Tg-mg-T35640-Ab-1/ GM-Tg-mg-T35640-Ab-2; GM-Tg-cynog-T35640-Ab-1/ GM-Tg-cynog-T35640-Ab-2;
GM-Tg-felg-T35640-Ab-1/ GM-Tg-felg-T35640-Ab-2; GM-Tg-cang-T35640-Ab-1/ GM-Tg-cang-T35640-Ab-2;
GM-Tg-bovg-T35640-Ab-1/ GM-Tg-bovg-T35640-Ab-2; GM-Tg-equg-T35640-Ab-1/ GM-Tg-equg-T35640-Ab-2
Products NameAnti-ITGAL monoclonal antibody
Formatmab
Target NameITGAL
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-ITGAL benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    BiosimilarGMP-Bios-INN-931Pre-Made Odulimomab Biosimilar, Fab Fusion, Anti-Itgal Antibody: Anti-CD11A/LFA-1/LFA1A therapeutic antibody
    BiosimilarGMP-Bios-INN-981Pre-Made Rovelizumab Biosimilar, Bispecific, Anti-Itgal;Itgb2 Antibody: Anti-CD11A/LFA-1/LFA1A;CD18/LAD/LCAMB/LFA-1/MAC-1/MF17/MFI7 therapeutic antibody
    BiosimilarGMP-Bios-ab-166Pre-Made Efalizumab biosimilar, Whole mAb, Anti-ITGAL Antibody: Anti-CD11A/LFA-1/LFA1A therapeutic antibody
    Target AntigenProducts DevelopingMulti-species ITAL/ ITGAL/ CD11A VLP (virus-like particle) (Products Developing)
    ORF Viral VectorpGMLP000685human ITGAL Lentivirus plasmid
    ORF Viral VectorvGMLP000685human ITGAL Lentivirus particle


    Target information

    Target IDGM-T35640
    Target NameITGAL
    Gene ID3683,16408,308995,711945,489905,101085940,281874,100065508
    Gene Symbol and Synonyms(p180),CD11A,ITGAL,LFA-1,LFA-1A,LFA1A,Ly-15,Ly-21
    Uniprot AccessionP20701,P61625
    Uniprot Entry NameITAL_HUMAN,ITAL_BOVIN
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target, INN Index
    DiseaseCancer
    Gene EnsemblENSG00000005844
    Target ClassificationTumor-associated antigen (TAA)

    The target: ITGAL, gene name: ITGAL, also named as CD11A, LFA-1, LFA1A. ITGAL encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1-3 (intercellular adhesion molecules 1 through 3), and also functions in lymphocyte costimulatory signaling. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.