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Anti-ITAL/ ITGAL/ CD11A monoclonal antibody
Anti-ITAL/ ITGAL/ CD11A antibody for FACS & in-vivo assay
Go to ITGAL/ITGAL products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T35640-Ab-1/ GM-Tg-hg-T35640-Ab-2 | Anti-Human ITGAL monoclonal antibody | Human |
| GM-Tg-rg-T35640-Ab-1/ GM-Tg-rg-T35640-Ab-2 | Anti-Rat ITGAL monoclonal antibody | Rat |
| GM-Tg-mg-T35640-Ab-1/ GM-Tg-mg-T35640-Ab-2 | Anti-Mouse ITGAL monoclonal antibody | Mouse |
| GM-Tg-cynog-T35640-Ab-1/ GM-Tg-cynog-T35640-Ab-2 | Anti-Cynomolgus/ Rhesus macaque ITGAL monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T35640-Ab-1/ GM-Tg-felg-T35640-Ab-2 | Anti-Feline ITGAL monoclonal antibody | Feline |
| GM-Tg-cang-T35640-Ab-1/ GM-Tg-cang-T35640-Ab-2 | Anti-Canine ITGAL monoclonal antibody | Canine |
| GM-Tg-bovg-T35640-Ab-1/ GM-Tg-bovg-T35640-Ab-2 | Anti-Bovine ITGAL monoclonal antibody | Bovine |
| GM-Tg-equg-T35640-Ab-1/ GM-Tg-equg-T35640-Ab-2 | Anti-Equine ITGAL monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T35640-Ab-1/ GM-Tg-hg-T35640-Ab-2; GM-Tg-rg-T35640-Ab-1/ GM-Tg-rg-T35640-Ab-2; GM-Tg-mg-T35640-Ab-1/ GM-Tg-mg-T35640-Ab-2; GM-Tg-cynog-T35640-Ab-1/ GM-Tg-cynog-T35640-Ab-2; GM-Tg-felg-T35640-Ab-1/ GM-Tg-felg-T35640-Ab-2; GM-Tg-cang-T35640-Ab-1/ GM-Tg-cang-T35640-Ab-2; GM-Tg-bovg-T35640-Ab-1/ GM-Tg-bovg-T35640-Ab-2; GM-Tg-equg-T35640-Ab-1/ GM-Tg-equg-T35640-Ab-2 |
| Products Name | Anti-ITGAL monoclonal antibody |
| Format | mab |
| Target Name | ITGAL |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-ITGAL benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Biosimilar | GMP-Bios-INN-931 | Pre-Made Odulimomab Biosimilar, Fab Fusion, Anti-Itgal Antibody: Anti-CD11A/LFA-1/LFA1A therapeutic antibody |
| Biosimilar | GMP-Bios-INN-981 | Pre-Made Rovelizumab Biosimilar, Bispecific, Anti-Itgal;Itgb2 Antibody: Anti-CD11A/LFA-1/LFA1A;CD18/LAD/LCAMB/LFA-1/MAC-1/MF17/MFI7 therapeutic antibody |
| Biosimilar | GMP-Bios-ab-166 | Pre-Made Efalizumab biosimilar, Whole mAb, Anti-ITGAL Antibody: Anti-CD11A/LFA-1/LFA1A therapeutic antibody |
| Target Antigen | Products Developing | Multi-species ITAL/ ITGAL/ CD11A VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | pGMLP000685 | human ITGAL Lentivirus plasmid |
| ORF Viral Vector | vGMLP000685 | human ITGAL Lentivirus particle |
Target information
| Target ID | GM-T35640 |
| Target Name | ITGAL |
| Gene ID | 3683,16408,308995,711945,489905,101085940,281874,100065508 |
| Gene Symbol and Synonyms | (p180),CD11A,ITGAL,LFA-1,LFA-1A,LFA1A,Ly-15,Ly-21 |
| Uniprot Accession | P20701,P61625 |
| Uniprot Entry Name | ITAL_HUMAN,ITAL_BOVIN |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target, INN Index |
| Disease | Cancer |
| Gene Ensembl | ENSG00000005844 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: ITGAL, gene name: ITGAL, also named as CD11A, LFA-1, LFA1A. ITGAL encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1-3 (intercellular adhesion molecules 1 through 3), and also functions in lymphocyte costimulatory signaling. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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