Anti-MSHR/ MC1R/ CMM5 monoclonal antibody

Anti-MSHR/ MC1R/ CMM5 antibody for FACS & in-vivo assay

Target products collectionGo to MC1R/MC1R products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T35842-Ab-1/ GM-Tg-hg-T35842-Ab-2Anti-Human MC1R monoclonal antibodyHuman
GM-Tg-rg-T35842-Ab-1/ GM-Tg-rg-T35842-Ab-2Anti-Rat MC1R monoclonal antibodyRat
GM-Tg-mg-T35842-Ab-1/ GM-Tg-mg-T35842-Ab-2Anti-Mouse MC1R monoclonal antibodyMouse
GM-Tg-cynog-T35842-Ab-1/ GM-Tg-cynog-T35842-Ab-2Anti-Cynomolgus/ Rhesus macaque MC1R monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T35842-Ab-1/ GM-Tg-felg-T35842-Ab-2Anti-Feline MC1R monoclonal antibodyFeline
GM-Tg-cang-T35842-Ab-1/ GM-Tg-cang-T35842-Ab-2Anti-Canine MC1R monoclonal antibodyCanine
GM-Tg-bovg-T35842-Ab-1/ GM-Tg-bovg-T35842-Ab-2Anti-Bovine MC1R monoclonal antibodyBovine
GM-Tg-equg-T35842-Ab-1/ GM-Tg-equg-T35842-Ab-2Anti-Equine MC1R monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T35842-Ab-1/ GM-Tg-hg-T35842-Ab-2; GM-Tg-rg-T35842-Ab-1/ GM-Tg-rg-T35842-Ab-2;
GM-Tg-mg-T35842-Ab-1/ GM-Tg-mg-T35842-Ab-2; GM-Tg-cynog-T35842-Ab-1/ GM-Tg-cynog-T35842-Ab-2;
GM-Tg-felg-T35842-Ab-1/ GM-Tg-felg-T35842-Ab-2; GM-Tg-cang-T35842-Ab-1/ GM-Tg-cang-T35842-Ab-2;
GM-Tg-bovg-T35842-Ab-1/ GM-Tg-bovg-T35842-Ab-2; GM-Tg-equg-T35842-Ab-1/ GM-Tg-equg-T35842-Ab-2
Products NameAnti-MC1R monoclonal antibody
Formatmab
Target NameMC1R
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-MC1R benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species MSHR/ MC1R/ CMM5 VLP (virus-like particle) (Products Developing)
    ORF Viral VectorvGMLP003534human MC1R Lentivirus particle
    ORF Viral VectorpGMLP003534human MC1R Lentivirus plasmid
    ORF Viral VectorpGMLPm000413mouse Mc1r Lentivirus plasmid
    ORF Viral VectorvGMLPm000413mouse Mc1r Lentivirus particle


    Target information

    Target IDGM-T35842
    Target NameMC1R
    Gene ID4157,17199,102552838,489652,493917,281298,100136907
    Gene Symbol and SynonymsCMM5,e,MC1-R,MC1R,Mcr1,MSH-R,MSHR,Mshra,SHEP2,Tob
    Uniprot AccessionQ01726,O77616,Q865E9,P47798,P79166
    Uniprot Entry NameMSHR_HUMAN,MSHR_FELCA,MSHR_CANLF,MSHR_BOVIN,MSHR_HORSE
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target
    DiseaseCancer
    Gene EnsemblENSG00000258839
    Target ClassificationGPCR, Tumor-associated antigen (TAA)

    The target: MC1R, gene name: MC1R, also named as CMM5, MSH-R, SHEP2. This intronless gene encodes the receptor protein for melanocyte-stimulating hormone (MSH). The encoded protein, a seven pass transmembrane G protein coupled receptor, controls melanogenesis. Two types of melanin exist: red pheomelanin and black eumelanin. Gene mutations that lead to a loss in function are associated with increased pheomelanin production, which leads to lighter skin and hair color. Eumelanin is photoprotective but pheomelanin may contribute to UV-induced skin damage by generating free radicals upon UV radiation. Binding of MSH to its receptor activates the receptor and stimulates eumelanin synthesis. This receptor is a major determining factor in sun sensitivity and is a genetic risk factor for melanoma and non-melanoma skin cancer. Over 30 variant alleles have been identified which correlate with skin and hair color, providing evidence that this gene is an important component in determining normal human pigment variation. [provided by RefSeq, Jul 2008].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.