Anti-AA3R/ ADORA3/ A3AR monoclonal antibody
Anti-AA3R/ ADORA3/ A3AR antibody for FACS & in-vivo assay
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(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
Product information
Catalog No. | Product Name | Species Reactivity |
---|---|---|
GM-Tg-hg-T36059-Ab-1/ GM-Tg-hg-T36059-Ab-2 | Anti-Human ADORA3 monoclonal antibody | Human |
GM-Tg-rg-T36059-Ab-1/ GM-Tg-rg-T36059-Ab-2 | Anti-Rat ADORA3 monoclonal antibody | Rat |
GM-Tg-mg-T36059-Ab-1/ GM-Tg-mg-T36059-Ab-2 | Anti-Mouse ADORA3 monoclonal antibody | Mouse |
GM-Tg-cynog-T36059-Ab-1/ GM-Tg-cynog-T36059-Ab-2 | Anti-Cynomolgus/ Rhesus macaque ADORA3 monoclonal antibody | Cynomolgus/ Rhesus macaque |
GM-Tg-felg-T36059-Ab-1/ GM-Tg-felg-T36059-Ab-2 | Anti-Feline ADORA3 monoclonal antibody | Feline |
GM-Tg-cang-T36059-Ab-1/ GM-Tg-cang-T36059-Ab-2 | Anti-Canine ADORA3 monoclonal antibody | Canine |
GM-Tg-bovg-T36059-Ab-1/ GM-Tg-bovg-T36059-Ab-2 | Anti-Bovine ADORA3 monoclonal antibody | Bovine |
GM-Tg-equg-T36059-Ab-1/ GM-Tg-equg-T36059-Ab-2 | Anti-Equine ADORA3 monoclonal antibody | Equine |
Size: 1mg | 10mg | 100mg
Product Description
Catalog No. | GM-Tg-hg-T36059-Ab-1/ GM-Tg-hg-T36059-Ab-2; GM-Tg-rg-T36059-Ab-1/ GM-Tg-rg-T36059-Ab-2; GM-Tg-mg-T36059-Ab-1/ GM-Tg-mg-T36059-Ab-2; GM-Tg-cynog-T36059-Ab-1/ GM-Tg-cynog-T36059-Ab-2; GM-Tg-felg-T36059-Ab-1/ GM-Tg-felg-T36059-Ab-2; GM-Tg-cang-T36059-Ab-1/ GM-Tg-cang-T36059-Ab-2; GM-Tg-bovg-T36059-Ab-1/ GM-Tg-bovg-T36059-Ab-2; GM-Tg-equg-T36059-Ab-1/ GM-Tg-equg-T36059-Ab-2 |
Products Name | Anti-ADORA3 monoclonal antibody |
Format | mab |
Target Name | ADORA3 |
Protein Sub-location | Transmembrane Protein |
Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
Derivation (species) | Mouse |
CH1+2+3 Isotype (Receptor identification) | IgG |
Type of Light Chain (VD-LC) | N/A |
Expression platform | Mammalian Expression |
Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
Tag | Fc |
Products description | Pre-made anti-ADORA3 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
Purity | Purity: ≥95% (SDS-PAGE) |
Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
Formulation | Lyophilized from sterile PBS, PH 7.4 |
Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
Category | Cat No. | Products Name |
Target Antigen | Products Developing | Multi-species AA3R/ ADORA3/ A3AR VLP (virus-like particle) (Products Developing) |
ORF Viral Vector | vGMLP003536 | human ADORA3 Lentivirus particle |
ORF Viral Vector | pGMLP003536 | human ADORA3 Lentivirus plasmid |
ORF Viral Vector | pGMLPm000883 | mouse Adora3 Lentivirus plasmid |
ORF Viral Vector | vGMLPm000883 | mouse Adora3 Lentivirus particle |
Target information
Target ID | GM-T36059 |
Target Name | ADORA3 |
Gene ID | 140,100911796,403805,101094689 |
Gene Symbol and Synonyms | A3,A3AR,ADORA3,TGPCR1 |
Uniprot Accession | P0DMS8,Q28309 |
Uniprot Entry Name | AA3R_HUMAN,AA3R_CANLF |
Protein Sub-location | Transmembrane Protein |
Category | Therapeutics Target, Immuno-oncology Target |
Disease | N/A |
Gene Ensembl | ENSG00000282608 |
Target Classification | Checkpoint-Immuno Oncology, GPCR |
The target: ADORA3, gene name: ADORA3, also named as A3AR. This gene encodes a protein that belongs to the family of adenosine receptors, which are G-protein-coupled receptors that are involved in a variety of intracellular signaling pathways and physiological functions. The receptor encoded by this gene mediates a sustained cardioprotective function during cardiac ischemia, it is involved in the inhibition of neutrophil degranulation in neutrophil-mediated tissue injury, it has been implicated in both neuroprotective and neurodegenerative effects, and it may also mediate both cell proliferation and cell death. Alternative splicing results in multiple transcript variants. This gene shares its 5' terminal exon with some transcripts from overlapping GeneID:57413, which encodes an immunoglobulin domain-containing protein. [provided by RefSeq, Nov 2014].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.