- • Up to 20% off your first purchase
- • Bulk quantities available
- • Citation Reward application
Sample Application
- Animal health test
- In-vitro diagnostics
- Food & Feed Safety
- Environmental Safety
- New drug discovery
Supports
- Talk to our Expert:
[email protected] -
Talk to our sales:
[email protected]
Protocol Library Download
 |
 |
Anti-SCN5A/ CDCD2/ CMD1E monoclonal antibody
Anti-SCN5A/ CDCD2/ CMD1E antibody for FACS & in-vivo assay
Go to SCN5A/SCN5A products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T39716-Ab-1/ GM-Tg-hg-T39716-Ab-2 | Anti-Human SCN5A monoclonal antibody | Human |
| GM-Tg-rg-T39716-Ab-1/ GM-Tg-rg-T39716-Ab-2 | Anti-Rat SCN5A monoclonal antibody | Rat |
| GM-Tg-mg-T39716-Ab-1/ GM-Tg-mg-T39716-Ab-2 | Anti-Mouse SCN5A monoclonal antibody | Mouse |
| GM-Tg-cynog-T39716-Ab-1/ GM-Tg-cynog-T39716-Ab-2 | Anti-Cynomolgus/ Rhesus macaque SCN5A monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T39716-Ab-1/ GM-Tg-felg-T39716-Ab-2 | Anti-Feline SCN5A monoclonal antibody | Feline |
| GM-Tg-cang-T39716-Ab-1/ GM-Tg-cang-T39716-Ab-2 | Anti-Canine SCN5A monoclonal antibody | Canine |
| GM-Tg-bovg-T39716-Ab-1/ GM-Tg-bovg-T39716-Ab-2 | Anti-Bovine SCN5A monoclonal antibody | Bovine |
| GM-Tg-equg-T39716-Ab-1/ GM-Tg-equg-T39716-Ab-2 | Anti-Equine SCN5A monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T39716-Ab-1/ GM-Tg-hg-T39716-Ab-2; GM-Tg-rg-T39716-Ab-1/ GM-Tg-rg-T39716-Ab-2; GM-Tg-mg-T39716-Ab-1/ GM-Tg-mg-T39716-Ab-2; GM-Tg-cynog-T39716-Ab-1/ GM-Tg-cynog-T39716-Ab-2; GM-Tg-felg-T39716-Ab-1/ GM-Tg-felg-T39716-Ab-2; GM-Tg-cang-T39716-Ab-1/ GM-Tg-cang-T39716-Ab-2; GM-Tg-bovg-T39716-Ab-1/ GM-Tg-bovg-T39716-Ab-2; GM-Tg-equg-T39716-Ab-1/ GM-Tg-equg-T39716-Ab-2 |
| Products Name | Anti-SCN5A monoclonal antibody |
| Format | mab |
| Target Name | SCN5A |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-SCN5A benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species SCN5A/ CDCD2/ CMD1E VLP (virus-like particle) (Products Developing) |
Target information
| Target ID | GM-T39716 |
| Target Name | SCN5A |
| Gene ID | 6331,20271,25665,695085,403497,101100994,282061,100034027 |
| Gene Symbol and Synonyms | CDCD2,CMD1E,CMPD2,HB1,HB2,HBBD,HH1,ICCD,IVF,LQT3,mH1,Nav1.5,Nav1.5c,PFHB1,RATRSKM2X,rSkM2,RSKM2X,SCAL,Scn2x,SCN5A,SkM1,SkM2,SSS1,VF1 |
| Uniprot Accession | Q14524,P15389 |
| Uniprot Entry Name | SCN5A_HUMAN,SCN5A_RAT |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000183873 |
| Target Classification | Ion Channel |
The target: SCN5A, gene name: SCN5A, also named as CDCD2, CMD1E, CMPD2, HB1, HB2, HBBD, HH1, ICCD, IVF, LQT3, Nav1.5, PFHB1, SSS1, VF1. The protein encoded by this gene is an integral membrane protein and tetrodotoxin-resistant voltage-gated sodium channel subunit. This protein is found primarily in cardiac muscle and is responsible for the initial upstroke of the action potential in an electrocardiogram. Defects in this gene have been associated with long QT syndrome type 3 (LQT3), atrial fibrillation, cardiomyopathy, and Brugada syndrome 1, all autosomal dominant cardiac diseases. Alternative splicing results in several transcript variants encoding different isoforms. [provided by RefSeq, May 2022].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
Facebook
LinkedIn
Twitter
