Anti-NR3C1 monoclonal antibody
Pre-made anti-NR3C1 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
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(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
Product information
Catalog No. | Product Name | Species Reactivity |
---|---|---|
GM-Tg-hg-T40016-Ab-1/ GM-Tg-hg-T40016-Ab-2 | Anti-Human NR3C1 monoclonal antibody | Human |
GM-Tg-rg-T40016-Ab-1/ GM-Tg-rg-T40016-Ab-2 | Anti-Rat NR3C1 monoclonal antibody | Rat |
GM-Tg-mg-T40016-Ab-1/ GM-Tg-mg-T40016-Ab-2 | Anti-Mouse NR3C1 monoclonal antibody | Mouse |
GM-Tg-cynog-T40016-Ab-1/ GM-Tg-cynog-T40016-Ab-2 | Anti-Cynomolgus/ Rhesus macaque NR3C1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
GM-Tg-felg-T40016-Ab-1/ GM-Tg-felg-T40016-Ab-2 | Anti-Feline NR3C1 monoclonal antibody | Feline |
GM-Tg-cang-T40016-Ab-1/ GM-Tg-cang-T40016-Ab-2 | Anti-Canine NR3C1 monoclonal antibody | Canine |
GM-Tg-bovg-T40016-Ab-1/ GM-Tg-bovg-T40016-Ab-2 | Anti-Bovine NR3C1 monoclonal antibody | Bovine |
GM-Tg-equg-T40016-Ab-1/ GM-Tg-equg-T40016-Ab-2 | Anti-Equine NR3C1 monoclonal antibody | Equine |
Size: 1mg | 10mg | 100mg
Product Description
Catalog No. | GM-Tg-hg-T40016-Ab-1/ GM-Tg-hg-T40016-Ab-2; GM-Tg-rg-T40016-Ab-1/ GM-Tg-rg-T40016-Ab-2; GM-Tg-mg-T40016-Ab-1/ GM-Tg-mg-T40016-Ab-2; GM-Tg-cynog-T40016-Ab-1/ GM-Tg-cynog-T40016-Ab-2; GM-Tg-felg-T40016-Ab-1/ GM-Tg-felg-T40016-Ab-2; GM-Tg-cang-T40016-Ab-1/ GM-Tg-cang-T40016-Ab-2; GM-Tg-bovg-T40016-Ab-1/ GM-Tg-bovg-T40016-Ab-2; GM-Tg-equg-T40016-Ab-1/ GM-Tg-equg-T40016-Ab-2 |
Products Name | Anti-NR3C1 monoclonal antibody |
Format | mab |
Target Name | NR3C1 |
Protein Sub-location | Introcelluar Protein |
Category of antibody | Therapeutics Target antibody |
Derivation (species) | Mouse |
CH1+2+3 Isotype (Receptor identification) | IgG |
Type of Light Chain (VD-LC) | N/A |
Expression platform | Mammalian Expression |
Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
Tag | Fc |
Products description | Pre-made anti-NR3C1 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
Purity | Purity: ≥95% (SDS-PAGE) |
Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
Category | Cat No. | Products Name |
Biosimilar | GMP-Bios-ab-627 | Pre-Made Volagidemab biosimilar, Whole mAb, Anti-GCCR/NR3C1 Antibody: Anti-GCR/GCRST/GR/GRL therapeutic antibody |
Target Antigen | GM-Tg-g-T40016-Ag-1 | Recombinant multi-species GCR/ NR3C1/ GCCR protein |
ORF Viral Vector | pGMAAV000039 | mouse Nr3c1 AAV plasmid |
ORF Viral Vector | pGMAAV000177 | house mouse Nr3c1 AAV plasmid |
ORF Viral Vector | vGMAAV000039 | mouse Nr3c1 AAV particle |
ORF Viral Vector | vGMAAV000177 | house mouse Nr3c1 AAV particle |
Target information
Target ID | GM-T40016 |
Target Name | NR3C1 |
Gene ID | 2908,14815,24413,706198,478047,101080939,281946,100061217 |
Gene Symbol and Synonyms | GCCR,GCL,GCR,GCRST,GR,GR-A,GRL,Grl-1,Grl1,NR3C1 |
Uniprot Accession | P04150,P06536 |
Uniprot Entry Name | GCR_HUMAN,GCR_RAT |
Protein Sub-location | Introcelluar Protein |
Category | Therapeutics Target, Immuno-oncology Target, INN Index |
Disease | Cancer |
Gene Ensembl | ENSG00000113580 |
Target Classification | Checkpoint-Immuno Oncology, Nuclear Receptors, Tumor-associated antigen (TAA) |
The target: NR3C1, gene name: NR3C1, also named as GCCR, GCR, GCRST, GR, GRL. This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID:15866175). [provided by RefSeq, Feb 2011].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.