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Anti-XDH/ XAN1/ XO functional antibody
Anti-XDH/ XAN1/ XO functional antibody for cell culture, ELISA & in-vivo assay
Go to XDH/XDH products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T40954-Ab-1/ GM-Tg-hg-T40954-Ab-2 | Anti-Human XDH monoclonal antibody | Human |
| GM-Tg-rg-T40954-Ab-1/ GM-Tg-rg-T40954-Ab-2 | Anti-Rat XDH monoclonal antibody | Rat |
| GM-Tg-mg-T40954-Ab-1/ GM-Tg-mg-T40954-Ab-2 | Anti-Mouse XDH monoclonal antibody | Mouse |
| GM-Tg-cynog-T40954-Ab-1/ GM-Tg-cynog-T40954-Ab-2 | Anti-Cynomolgus/ Rhesus macaque XDH monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T40954-Ab-1/ GM-Tg-felg-T40954-Ab-2 | Anti-Feline XDH monoclonal antibody | Feline |
| GM-Tg-cang-T40954-Ab-1/ GM-Tg-cang-T40954-Ab-2 | Anti-Canine XDH monoclonal antibody | Canine |
| GM-Tg-bovg-T40954-Ab-1/ GM-Tg-bovg-T40954-Ab-2 | Anti-Bovine XDH monoclonal antibody | Bovine |
| GM-Tg-equg-T40954-Ab-1/ GM-Tg-equg-T40954-Ab-2 | Anti-Equine XDH monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T40954-Ab-1/ GM-Tg-hg-T40954-Ab-2; GM-Tg-rg-T40954-Ab-1/ GM-Tg-rg-T40954-Ab-2; GM-Tg-mg-T40954-Ab-1/ GM-Tg-mg-T40954-Ab-2; GM-Tg-cynog-T40954-Ab-1/ GM-Tg-cynog-T40954-Ab-2; GM-Tg-felg-T40954-Ab-1/ GM-Tg-felg-T40954-Ab-2; GM-Tg-cang-T40954-Ab-1/ GM-Tg-cang-T40954-Ab-2; GM-Tg-bovg-T40954-Ab-1/ GM-Tg-bovg-T40954-Ab-2; GM-Tg-equg-T40954-Ab-1/ GM-Tg-equg-T40954-Ab-2 |
| Products Name | Anti-XDH monoclonal antibody |
| Format | mab |
| Target Name | XDH |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-XDH benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T40954-Ag-1 | Recombinant multi-species XDH/ XAN1/ XO protein |
| ORF Viral Vector | vGMAD000414 | human XDH Adenovirus particle |
| ORF Viral Vector | pGMAD000414 | human XDH Adenovirus plasmid |
| ORF Viral Vector | vGMAD000009 | human XDH Adenovirus particle |
| ORF Viral Vector | pGMAD000009 | human XDH Adenovirus plasmid |
Target information
| Target ID | GM-T40954 |
| Target Name | XDH |
| Gene ID | 7498,22436,497811,708046,280960 |
| Gene Symbol and Synonyms | XAN1,XDH,XO,XOR,Xox-1,Xox1 |
| Uniprot Accession | P47989,P22985,P80457 |
| Uniprot Entry Name | XDH_HUMAN,XDH_RAT,XDH_BOVIN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | Therapeutics Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000158125 |
| Target Classification | N/A |
The target: XDH, gene name: XDH, also named as XAN1, XO, XOR. Xanthine dehydrogenase belongs to the group of molybdenum-containing hydroxylases involved in the oxidative metabolism of purines. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Xanthine dehydrogenase can be converted to xanthine oxidase by reversible sulfhydryl oxidation or by irreversible proteolytic modification. Defects in xanthine dehydrogenase cause xanthinuria, may contribute to adult respiratory stress syndrome, and may potentiate influenza infection through an oxygen metabolite-dependent mechanism. [provided by RefSeq, Jan 2014].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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