Anti-FECH monoclonal antibody

Pre-made anti-FECH monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research

Target products collectionGo to FECH/FECH products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)


Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T42822-Ab-1/ GM-Tg-hg-T42822-Ab-2Anti-Human FECH monoclonal antibodyHuman
GM-Tg-rg-T42822-Ab-1/ GM-Tg-rg-T42822-Ab-2Anti-Rat FECH monoclonal antibodyRat
GM-Tg-mg-T42822-Ab-1/ GM-Tg-mg-T42822-Ab-2Anti-Mouse FECH monoclonal antibodyMouse
GM-Tg-cynog-T42822-Ab-1/ GM-Tg-cynog-T42822-Ab-2Anti-Cynomolgus/ Rhesus macaque FECH monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T42822-Ab-1/ GM-Tg-felg-T42822-Ab-2Anti-Feline FECH monoclonal antibodyFeline
GM-Tg-cang-T42822-Ab-1/ GM-Tg-cang-T42822-Ab-2Anti-Canine FECH monoclonal antibodyCanine
GM-Tg-bovg-T42822-Ab-1/ GM-Tg-bovg-T42822-Ab-2Anti-Bovine FECH monoclonal antibodyBovine
GM-Tg-equg-T42822-Ab-1/ GM-Tg-equg-T42822-Ab-2Anti-Equine FECH monoclonal antibodyEquine

Size: 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T42822-Ab-1/ GM-Tg-hg-T42822-Ab-2; GM-Tg-rg-T42822-Ab-1/ GM-Tg-rg-T42822-Ab-2;
GM-Tg-mg-T42822-Ab-1/ GM-Tg-mg-T42822-Ab-2; GM-Tg-cynog-T42822-Ab-1/ GM-Tg-cynog-T42822-Ab-2;
GM-Tg-felg-T42822-Ab-1/ GM-Tg-felg-T42822-Ab-2; GM-Tg-cang-T42822-Ab-1/ GM-Tg-cang-T42822-Ab-2;
GM-Tg-bovg-T42822-Ab-1/ GM-Tg-bovg-T42822-Ab-2; GM-Tg-equg-T42822-Ab-1/ GM-Tg-equg-T42822-Ab-2
Products NameAnti-FECH monoclonal antibody
Formatmab
Target NameFECH
Protein Sub-locationIntrocelluar Protein
Category of antibodyTherapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)
IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected.
TagFc
Products descriptionPre-made anti-FECH monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


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    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-T42822-Ag-1Recombinant multi-species HEMH/ FECH/ EPP protein
    ORF Viral VectorvGMLP001499human FECH Lentivirus particle
    ORF Viral VectorpGMLP001499human FECH Lentivirus plasmid
    ORF Viral VectorpGMLPm005142mouse Fech Lentivirus plasmid
    ORF Viral VectorvGMLPm005142mouse Fech Lentivirus particle


    Target information

    Target IDGM-T42822
    Target NameFECH
    Gene ID2235,14151,361338,695759,610360,101087879,281158,100054014
    Gene Symbol and SynonymsEPP,EPP1,FCE,fch,Fcl,FECH
    Uniprot AccessionP22830,P22600
    Uniprot Entry NameHEMH_HUMAN,HEMH_BOVIN
    Protein Sub-locationIntrocelluar Protein
    CategoryTherapeutics Target
    DiseaseTumors
    Gene EnsemblENSG00000066926
    Target ClassificationN/A

    The target: FECH, gene name: FECH, also named as EPP, EPP1, FCE. The protein encoded by this gene is localized to the mitochondrion, where it catalyzes the insertion of the ferrous form of iron into protoporphyrin IX in the heme synthesis pathway. Mutations in this gene are associated with erythropoietic protoporphyria. Two transcript variants encoding different isoforms have been found for this gene. A pseudogene of this gene is found on chromosome 3.[provided by RefSeq, May 2010].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.