Anti-FA7/ F7/ SPCA monoclonal antibody

Anti-FA7/ F7/ SPCA antibody for FACS & in-vivo assay

Target products collectionGo to F7/F7 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T43332-Ab-1/ GM-Tg-hg-T43332-Ab-2Anti-Human F7 monoclonal antibodyHuman
GM-Tg-rg-T43332-Ab-1/ GM-Tg-rg-T43332-Ab-2Anti-Rat F7 monoclonal antibodyRat
GM-Tg-mg-T43332-Ab-1/ GM-Tg-mg-T43332-Ab-2Anti-Mouse F7 monoclonal antibodyMouse
GM-Tg-cynog-T43332-Ab-1/ GM-Tg-cynog-T43332-Ab-2Anti-Cynomolgus/ Rhesus macaque F7 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T43332-Ab-1/ GM-Tg-felg-T43332-Ab-2Anti-Feline F7 monoclonal antibodyFeline
GM-Tg-cang-T43332-Ab-1/ GM-Tg-cang-T43332-Ab-2Anti-Canine F7 monoclonal antibodyCanine
GM-Tg-bovg-T43332-Ab-1/ GM-Tg-bovg-T43332-Ab-2Anti-Bovine F7 monoclonal antibodyBovine
GM-Tg-equg-T43332-Ab-1/ GM-Tg-equg-T43332-Ab-2Anti-Equine F7 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T43332-Ab-1/ GM-Tg-hg-T43332-Ab-2; GM-Tg-rg-T43332-Ab-1/ GM-Tg-rg-T43332-Ab-2;
GM-Tg-mg-T43332-Ab-1/ GM-Tg-mg-T43332-Ab-2; GM-Tg-cynog-T43332-Ab-1/ GM-Tg-cynog-T43332-Ab-2;
GM-Tg-felg-T43332-Ab-1/ GM-Tg-felg-T43332-Ab-2; GM-Tg-cang-T43332-Ab-1/ GM-Tg-cang-T43332-Ab-2;
GM-Tg-bovg-T43332-Ab-1/ GM-Tg-bovg-T43332-Ab-2; GM-Tg-equg-T43332-Ab-1/ GM-Tg-equg-T43332-Ab-2
Products NameAnti-F7 monoclonal antibody
Formatmab
Target NameF7
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-F7 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


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    Associated products


    CategoryCat No.Products Name
    BiosimilarGMP-Bios-INN-842Pre-Made Eptacog Alfa (Actived Biosimilar, Recombinant Protein targeting F7: Recombinant therapeutic protein targeting SPCA
    BiosimilarGMP-Bios-INN-941Pre-Made Oreptacog Alfa Biosimilar, Recombinant Protein targeting F7: Recombinant therapeutic protein targeting SPCA
    Target AntigenProducts DevelopingMulti-species FA7/ F7/ SPCA VLP (virus-like particle) (Products Developing)
    ORF Viral VectorvGMLP001936human F7 Lentivirus particle
    ORF Viral VectorpGMLP001936human F7 Lentivirus plasmid
    ORF Viral VectorpGMLPm001782mouse F7 Lentivirus plasmid
    ORF Viral VectorvGMLPm001782mouse F7 Lentivirus particle


    Target information

    Target IDGM-T43332
    Target NameF7
    Gene ID2155,14068,260320,721933,607661,101090581,617960,100067072
    Gene Symbol and SynonymsCf7,F7,FVII,SPCA
    Uniprot AccessionP08709,Q8K3U6,P22457
    Uniprot Entry NameFA7_HUMAN,FA7_RAT,FA7_BOVIN
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target, INN Index
    DiseaseN/A
    Gene EnsemblENSG00000057593
    Target ClassificationN/A

    The target: F7, gene name: F7, also named as SPCA. This gene encodes coagulation factor VII which is a vitamin K-dependent factor essential for hemostasis. This factor circulates in the blood in a zymogen form, and is converted to an active form by either factor IXa, factor Xa, factor XIIa, or thrombin by minor proteolysis. Upon activation of the factor VII, a heavy chain containing a catalytic domain and a light chain containing 2 EGF-like domains are generated, and two chains are held together by a disulfide bond. In the presence of factor III and calcium ions, the activated factor then further activates the coagulation cascade by converting factor IX to factor IXa and/or factor X to factor Xa. Defects in this gene can cause coagulopathy. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing to generate mature polypeptides. [provided by RefSeq, Aug 2015].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.