Anti-FA7/ F7/ SPCA monoclonal antibody
Anti-FA7/ F7/ SPCA antibody for FACS & in-vivo assay
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(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
Product information
Catalog No. | Product Name | Species Reactivity |
---|---|---|
GM-Tg-hg-T43332-Ab-1/ GM-Tg-hg-T43332-Ab-2 | Anti-Human F7 monoclonal antibody | Human |
GM-Tg-rg-T43332-Ab-1/ GM-Tg-rg-T43332-Ab-2 | Anti-Rat F7 monoclonal antibody | Rat |
GM-Tg-mg-T43332-Ab-1/ GM-Tg-mg-T43332-Ab-2 | Anti-Mouse F7 monoclonal antibody | Mouse |
GM-Tg-cynog-T43332-Ab-1/ GM-Tg-cynog-T43332-Ab-2 | Anti-Cynomolgus/ Rhesus macaque F7 monoclonal antibody | Cynomolgus/ Rhesus macaque |
GM-Tg-felg-T43332-Ab-1/ GM-Tg-felg-T43332-Ab-2 | Anti-Feline F7 monoclonal antibody | Feline |
GM-Tg-cang-T43332-Ab-1/ GM-Tg-cang-T43332-Ab-2 | Anti-Canine F7 monoclonal antibody | Canine |
GM-Tg-bovg-T43332-Ab-1/ GM-Tg-bovg-T43332-Ab-2 | Anti-Bovine F7 monoclonal antibody | Bovine |
GM-Tg-equg-T43332-Ab-1/ GM-Tg-equg-T43332-Ab-2 | Anti-Equine F7 monoclonal antibody | Equine |
Size: 1mg | 10mg | 100mg
Product Description
Catalog No. | GM-Tg-hg-T43332-Ab-1/ GM-Tg-hg-T43332-Ab-2; GM-Tg-rg-T43332-Ab-1/ GM-Tg-rg-T43332-Ab-2; GM-Tg-mg-T43332-Ab-1/ GM-Tg-mg-T43332-Ab-2; GM-Tg-cynog-T43332-Ab-1/ GM-Tg-cynog-T43332-Ab-2; GM-Tg-felg-T43332-Ab-1/ GM-Tg-felg-T43332-Ab-2; GM-Tg-cang-T43332-Ab-1/ GM-Tg-cang-T43332-Ab-2; GM-Tg-bovg-T43332-Ab-1/ GM-Tg-bovg-T43332-Ab-2; GM-Tg-equg-T43332-Ab-1/ GM-Tg-equg-T43332-Ab-2 |
Products Name | Anti-F7 monoclonal antibody |
Format | mab |
Target Name | F7 |
Protein Sub-location | Transmembrane Protein |
Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
Derivation (species) | Mouse |
CH1+2+3 Isotype (Receptor identification) | IgG |
Type of Light Chain (VD-LC) | N/A |
Expression platform | Mammalian Expression |
Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
Tag | Fc |
Products description | Pre-made anti-F7 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
Purity | Purity: ≥95% (SDS-PAGE) |
Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
Category | Cat No. | Products Name |
Biosimilar | GMP-Bios-INN-842 | Pre-Made Eptacog Alfa (Actived Biosimilar, Recombinant Protein targeting F7: Recombinant therapeutic protein targeting SPCA |
Biosimilar | GMP-Bios-INN-941 | Pre-Made Oreptacog Alfa Biosimilar, Recombinant Protein targeting F7: Recombinant therapeutic protein targeting SPCA |
Target Antigen | Products Developing | Multi-species FA7/ F7/ SPCA VLP (virus-like particle) (Products Developing) |
ORF Viral Vector | vGMLP001936 | human F7 Lentivirus particle |
ORF Viral Vector | pGMLP001936 | human F7 Lentivirus plasmid |
ORF Viral Vector | pGMLPm001782 | mouse F7 Lentivirus plasmid |
ORF Viral Vector | vGMLPm001782 | mouse F7 Lentivirus particle |
Target information
Target ID | GM-T43332 |
Target Name | F7 |
Gene ID | 2155,14068,260320,721933,607661,101090581,617960,100067072 |
Gene Symbol and Synonyms | Cf7,F7,FVII,SPCA |
Uniprot Accession | P08709,Q8K3U6,P22457 |
Uniprot Entry Name | FA7_HUMAN,FA7_RAT,FA7_BOVIN |
Protein Sub-location | Transmembrane Protein |
Category | Therapeutics Target, INN Index |
Disease | N/A |
Gene Ensembl | ENSG00000057593 |
Target Classification | N/A |
The target: F7, gene name: F7, also named as SPCA. This gene encodes coagulation factor VII which is a vitamin K-dependent factor essential for hemostasis. This factor circulates in the blood in a zymogen form, and is converted to an active form by either factor IXa, factor Xa, factor XIIa, or thrombin by minor proteolysis. Upon activation of the factor VII, a heavy chain containing a catalytic domain and a light chain containing 2 EGF-like domains are generated, and two chains are held together by a disulfide bond. In the presence of factor III and calcium ions, the activated factor then further activates the coagulation cascade by converting factor IX to factor IXa and/or factor X to factor Xa. Defects in this gene can cause coagulopathy. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing to generate mature polypeptides. [provided by RefSeq, Aug 2015].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.