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Anti-ADRB1/ ADRB1R/ B1AR monoclonal antibody
Anti-ADRB1/ ADRB1R/ B1AR antibody for FACS & in-vivo assay
Go to ADRB1/ADRB1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T44068-Ab-1/ GM-Tg-hg-T44068-Ab-2 | Anti-Human ADRB1 monoclonal antibody | Human |
| GM-Tg-rg-T44068-Ab-1/ GM-Tg-rg-T44068-Ab-2 | Anti-Rat ADRB1 monoclonal antibody | Rat |
| GM-Tg-mg-T44068-Ab-1/ GM-Tg-mg-T44068-Ab-2 | Anti-Mouse ADRB1 monoclonal antibody | Mouse |
| GM-Tg-cynog-T44068-Ab-1/ GM-Tg-cynog-T44068-Ab-2 | Anti-Cynomolgus/ Rhesus macaque ADRB1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T44068-Ab-1/ GM-Tg-felg-T44068-Ab-2 | Anti-Feline ADRB1 monoclonal antibody | Feline |
| GM-Tg-cang-T44068-Ab-1/ GM-Tg-cang-T44068-Ab-2 | Anti-Canine ADRB1 monoclonal antibody | Canine |
| GM-Tg-bovg-T44068-Ab-1/ GM-Tg-bovg-T44068-Ab-2 | Anti-Bovine ADRB1 monoclonal antibody | Bovine |
| GM-Tg-equg-T44068-Ab-1/ GM-Tg-equg-T44068-Ab-2 | Anti-Equine ADRB1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T44068-Ab-1/ GM-Tg-hg-T44068-Ab-2; GM-Tg-rg-T44068-Ab-1/ GM-Tg-rg-T44068-Ab-2; GM-Tg-mg-T44068-Ab-1/ GM-Tg-mg-T44068-Ab-2; GM-Tg-cynog-T44068-Ab-1/ GM-Tg-cynog-T44068-Ab-2; GM-Tg-felg-T44068-Ab-1/ GM-Tg-felg-T44068-Ab-2; GM-Tg-cang-T44068-Ab-1/ GM-Tg-cang-T44068-Ab-2; GM-Tg-bovg-T44068-Ab-1/ GM-Tg-bovg-T44068-Ab-2; GM-Tg-equg-T44068-Ab-1/ GM-Tg-equg-T44068-Ab-2 |
| Products Name | Anti-ADRB1 monoclonal antibody |
| Format | mab |
| Target Name | ADRB1 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-ADRB1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species ADRB1/ ADRB1R/ B1AR VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | pGMAD000197 | mouse Adrb1 Adenovirus plasmid |
| ORF Viral Vector | pGMAD000451 | house mouse Adrb1 Adenovirus plasmid |
| ORF Viral Vector | vGMAD000197 | mouse Adrb1 Adenovirus particle |
| ORF Viral Vector | vGMAD000451 | house mouse Adrb1 Adenovirus particle |
Target information
| Target ID | GM-T44068 |
| Target Name | ADRB1 |
| Gene ID | 153,11554,24925,100426598,493972,493971,281604,100146832 |
| Gene Symbol and Synonyms | Adrb-1,ADRB1,ADRB1R,B1AR,beta-AR,BETA1AR,FNSS2,RATB1AR,RHR |
| Uniprot Accession | P08588,P18090,P47899,P79148,Q9TST6,Q9TT96 |
| Uniprot Entry Name | ADRB1_HUMAN,ADRB1_MACMU,ADRB1_RAT,ADRB1_FELCA,ADRB1_CANLF,ADRB1_BOVIN |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000043591 |
| Target Classification | GPCR |
The target: ADRB1, gene name: ADRB1, also named as ADRB1R, B1AR, BETA1AR, RHR. The adrenergic receptors (subtypes alpha 1, alpha 2, beta 1, and beta 2) are a prototypic family of guanine nucleotide binding regulatory protein-coupled receptors that mediate the physiological effects of the hormone epinephrine and the neurotransmitter norepinephrine. Beta-1 adrenoceptors are predominately located in the heart. Specific polymorphisms in this gene have been shown to affect the resting heart rate and can be involved in heart failure. [provided by RefSeq, Sep 2019].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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