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Anti-CRFR1/ CRHR1/ CRF-R monoclonal antibody
Anti-CRFR1/ CRHR1/ CRF-R antibody for FACS & in-vivo assay
Go to CRHR1/CRHR1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T45262-Ab-1/ GM-Tg-hg-T45262-Ab-2 | Anti-Human CRHR1 monoclonal antibody | Human |
| GM-Tg-rg-T45262-Ab-1/ GM-Tg-rg-T45262-Ab-2 | Anti-Rat CRHR1 monoclonal antibody | Rat |
| GM-Tg-mg-T45262-Ab-1/ GM-Tg-mg-T45262-Ab-2 | Anti-Mouse CRHR1 monoclonal antibody | Mouse |
| GM-Tg-cynog-T45262-Ab-1/ GM-Tg-cynog-T45262-Ab-2 | Anti-Cynomolgus/ Rhesus macaque CRHR1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T45262-Ab-1/ GM-Tg-felg-T45262-Ab-2 | Anti-Feline CRHR1 monoclonal antibody | Feline |
| GM-Tg-cang-T45262-Ab-1/ GM-Tg-cang-T45262-Ab-2 | Anti-Canine CRHR1 monoclonal antibody | Canine |
| GM-Tg-bovg-T45262-Ab-1/ GM-Tg-bovg-T45262-Ab-2 | Anti-Bovine CRHR1 monoclonal antibody | Bovine |
| GM-Tg-equg-T45262-Ab-1/ GM-Tg-equg-T45262-Ab-2 | Anti-Equine CRHR1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T45262-Ab-1/ GM-Tg-hg-T45262-Ab-2; GM-Tg-rg-T45262-Ab-1/ GM-Tg-rg-T45262-Ab-2; GM-Tg-mg-T45262-Ab-1/ GM-Tg-mg-T45262-Ab-2; GM-Tg-cynog-T45262-Ab-1/ GM-Tg-cynog-T45262-Ab-2; GM-Tg-felg-T45262-Ab-1/ GM-Tg-felg-T45262-Ab-2; GM-Tg-cang-T45262-Ab-1/ GM-Tg-cang-T45262-Ab-2; GM-Tg-bovg-T45262-Ab-1/ GM-Tg-bovg-T45262-Ab-2; GM-Tg-equg-T45262-Ab-1/ GM-Tg-equg-T45262-Ab-2 |
| Products Name | Anti-CRHR1 monoclonal antibody |
| Format | mab |
| Target Name | CRHR1 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-CRHR1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species CRFR1/ CRHR1/ CRF-R VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | pGMLP003702 | human CRHR1 Lentivirus plasmid |
| ORF Viral Vector | vGMLP003702 | human CRHR1 Lentivirus particle |
| ORF Viral Vector | pGMAAV000036 | mouse Crhr1 AAV plasmid |
| ORF Viral Vector | vGMAAV000036 | mouse Crhr1 AAV particle |
Target information
| Target ID | GM-T45262 |
| Target Name | CRHR1 |
| Gene ID | 1394,12921,58959,574095,610380,101089308,281716,100065598 |
| Gene Symbol and Synonyms | CRF-R,CRF-R-1,CRF-R1,CRF1,CRF1R,CRFR-1,CRFR1,CRH-R,CRH-R 1,CRH-R-1,CRH-R1,CRHR,CRHR1,CRHR1L |
| Uniprot Accession | P34998,P35353,Q76LL8 |
| Uniprot Entry Name | CRFR1_HUMAN,CRFR1_MACMU,CRFR1_RAT |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000120088 |
| Target Classification | GPCR |
The target: CRHR1, gene name: CRHR1, also named as CRF-R, CRF-R-1, CRF-R1, CRF1, CRFR-1, CRFR1, CRH-R-1, CRH-R1, CRHRL, CRHR1. This gene encodes a G-protein coupled receptor that binds neuropeptides of the corticotropin releasing hormone family that are major regulators of the hypothalamic-pituitary-adrenal pathway. The encoded protein is essential for the activation of signal transduction pathways that regulate diverse physiological processes including stress, reproduction, immune response and obesity. Alternative splicing results in multiple transcript variants. Naturally-occurring readthrough transcription between this gene and upstream GeneID:147081 results in transcripts that encode isoforms that share similarity with the products of this gene. [provided by RefSeq, Aug 2016].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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