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Anti-PMEL/ D12S53E/ ME20 monoclonal antibody
Anti-PMEL/ D12S53E/ ME20 antibody for FACS & in-vivo assay
Go to PMEL/PMEL products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T46128-Ab-1/ GM-Tg-hg-T46128-Ab-2 | Anti-Human PMEL monoclonal antibody | Human |
| GM-Tg-rg-T46128-Ab-1/ GM-Tg-rg-T46128-Ab-2 | Anti-Rat PMEL monoclonal antibody | Rat |
| GM-Tg-mg-T46128-Ab-1/ GM-Tg-mg-T46128-Ab-2 | Anti-Mouse PMEL monoclonal antibody | Mouse |
| GM-Tg-cynog-T46128-Ab-1/ GM-Tg-cynog-T46128-Ab-2 | Anti-Cynomolgus/ Rhesus macaque PMEL monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T46128-Ab-1/ GM-Tg-felg-T46128-Ab-2 | Anti-Feline PMEL monoclonal antibody | Feline |
| GM-Tg-cang-T46128-Ab-1/ GM-Tg-cang-T46128-Ab-2 | Anti-Canine PMEL monoclonal antibody | Canine |
| GM-Tg-bovg-T46128-Ab-1/ GM-Tg-bovg-T46128-Ab-2 | Anti-Bovine PMEL monoclonal antibody | Bovine |
| GM-Tg-equg-T46128-Ab-1/ GM-Tg-equg-T46128-Ab-2 | Anti-Equine PMEL monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T46128-Ab-1/ GM-Tg-hg-T46128-Ab-2; GM-Tg-rg-T46128-Ab-1/ GM-Tg-rg-T46128-Ab-2; GM-Tg-mg-T46128-Ab-1/ GM-Tg-mg-T46128-Ab-2; GM-Tg-cynog-T46128-Ab-1/ GM-Tg-cynog-T46128-Ab-2; GM-Tg-felg-T46128-Ab-1/ GM-Tg-felg-T46128-Ab-2; GM-Tg-cang-T46128-Ab-1/ GM-Tg-cang-T46128-Ab-2; GM-Tg-bovg-T46128-Ab-1/ GM-Tg-bovg-T46128-Ab-2; GM-Tg-equg-T46128-Ab-1/ GM-Tg-equg-T46128-Ab-2 |
| Products Name | Anti-PMEL monoclonal antibody |
| Format | mab |
| Target Name | PMEL |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-PMEL benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species PMEL/ D12S53E/ ME20 VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | pGMLPm005276 | mouse Pmel Lentivirus plasmid |
| ORF Viral Vector | vGMLPm005276 | mouse Pmel Lentivirus particle |
Target information
| Target ID | GM-T46128 |
| Target Name | PMEL |
| Gene ID | 6490,20431,362818,710921,481102,101092774,281487,100033885 |
| Gene Symbol and Synonyms | D10H12S53E,D12S53E,D12S53Eh,gp100,gp87,HMB-45,HMB45,ME20,ME20-M,ME20M,P1,P100,PMEL,PMEL17,RPE1,SI,SIL,SILV |
| Uniprot Accession | P40967,Q06154 |
| Uniprot Entry Name | PMEL_HUMAN,PMEL_BOVIN |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target, Immuno-oncology Target |
| Disease | Cancer |
| Gene Ensembl | ENSG00000185664 |
| Target Classification | Checkpoint-Immuno Oncology, Tumor-associated antigen (TAA) |
The target: PMEL, gene name: PMEL, also named as D12S53E, ME20, ME20-M, ME20M, P1, P10017, SI, SIL, SILV, gp100, PMEL. This gene encodes a melanocyte-specific type I transmembrane glycoprotein. The encoded protein is enriched in melanosomes, which are the melanin-producing organelles in melanocytes, and plays an essential role in the structural organization of premelanosomes. This protein is involved in generating internal matrix fibers that define the transition from Stage I to Stage II melanosomes. This protein undergoes a complex pattern of prosttranslational processing and modification that is essential to the proper functioning of the protein. A secreted form of this protein that is released by proteolytic ectodomain shedding may be used as a melanoma-specific serum marker. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2011].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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