Anti-MTP/ MTTP/ ABL functional antibody

Anti-MTP/ MTTP/ ABL functional antibody for cell culture, ELISA & in-vivo assay

Target products collectionGo to MTTP/MTTP products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)


Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T46628-Ab-1/ GM-Tg-hg-T46628-Ab-2Anti-Human MTTP monoclonal antibodyHuman
GM-Tg-rg-T46628-Ab-1/ GM-Tg-rg-T46628-Ab-2Anti-Rat MTTP monoclonal antibodyRat
GM-Tg-mg-T46628-Ab-1/ GM-Tg-mg-T46628-Ab-2Anti-Mouse MTTP monoclonal antibodyMouse
GM-Tg-cynog-T46628-Ab-1/ GM-Tg-cynog-T46628-Ab-2Anti-Cynomolgus/ Rhesus macaque MTTP monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T46628-Ab-1/ GM-Tg-felg-T46628-Ab-2Anti-Feline MTTP monoclonal antibodyFeline
GM-Tg-cang-T46628-Ab-1/ GM-Tg-cang-T46628-Ab-2Anti-Canine MTTP monoclonal antibodyCanine
GM-Tg-bovg-T46628-Ab-1/ GM-Tg-bovg-T46628-Ab-2Anti-Bovine MTTP monoclonal antibodyBovine
GM-Tg-equg-T46628-Ab-1/ GM-Tg-equg-T46628-Ab-2Anti-Equine MTTP monoclonal antibodyEquine

Size: 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T46628-Ab-1/ GM-Tg-hg-T46628-Ab-2; GM-Tg-rg-T46628-Ab-1/ GM-Tg-rg-T46628-Ab-2;
GM-Tg-mg-T46628-Ab-1/ GM-Tg-mg-T46628-Ab-2; GM-Tg-cynog-T46628-Ab-1/ GM-Tg-cynog-T46628-Ab-2;
GM-Tg-felg-T46628-Ab-1/ GM-Tg-felg-T46628-Ab-2; GM-Tg-cang-T46628-Ab-1/ GM-Tg-cang-T46628-Ab-2;
GM-Tg-bovg-T46628-Ab-1/ GM-Tg-bovg-T46628-Ab-2; GM-Tg-equg-T46628-Ab-1/ GM-Tg-equg-T46628-Ab-2
Products NameAnti-MTTP monoclonal antibody
Formatmab
Target NameMTTP
Protein Sub-locationSecreted Protein/Potential Cytokines
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)
IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-MTTP benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


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    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-T46628-Ag-1Recombinant multi-species MTP/ MTTP/ ABL protein
    ORF Viral VectorpGMLPm004722mouse Mttp Lentivirus plasmid
    ORF Viral VectorvGMLPm004722mouse Mttp Lentivirus particle


    Target information

    Target IDGM-T46628
    Target NameMTTP
    Gene ID4547,17777,310900,708832,487873,101087920,280868,100053803
    Gene Symbol and Synonyms1810043K16Rik,ABL,MTP,MTTP
    Uniprot AccessionP55157,D4A1W8,P55156
    Uniprot Entry NameMTP_HUMAN,MTP_RAT,MTP_BOVIN
    Protein Sub-locationSecreted Protein/Potential Cytokines
    CategoryTherapeutics Target
    DiseaseN/A
    Gene EnsemblENSG00000138823
    Target ClassificationN/A

    The target: MTTP, gene name: MTTP, also named as ABL, MTP. MTP encodes the large subunit of the heterodimeric microsomal triglyceride transfer protein. Protein disulfide isomerase (PDI) completes the heterodimeric microsomal triglyceride transfer protein, which has been shown to play a central role in lipoprotein assembly. Mutations in MTP can cause abetalipoproteinemia. [provided by RefSeq, Jul 2008].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.