Anti-MTP/ MTTP/ ABL functional antibody
Anti-MTP/ MTTP/ ABL functional antibody for cell culture, ELISA & in-vivo assay
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(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
Product information
Catalog No. | Product Name | Species Reactivity |
---|---|---|
GM-Tg-hg-T46628-Ab-1/ GM-Tg-hg-T46628-Ab-2 | Anti-Human MTTP monoclonal antibody | Human |
GM-Tg-rg-T46628-Ab-1/ GM-Tg-rg-T46628-Ab-2 | Anti-Rat MTTP monoclonal antibody | Rat |
GM-Tg-mg-T46628-Ab-1/ GM-Tg-mg-T46628-Ab-2 | Anti-Mouse MTTP monoclonal antibody | Mouse |
GM-Tg-cynog-T46628-Ab-1/ GM-Tg-cynog-T46628-Ab-2 | Anti-Cynomolgus/ Rhesus macaque MTTP monoclonal antibody | Cynomolgus/ Rhesus macaque |
GM-Tg-felg-T46628-Ab-1/ GM-Tg-felg-T46628-Ab-2 | Anti-Feline MTTP monoclonal antibody | Feline |
GM-Tg-cang-T46628-Ab-1/ GM-Tg-cang-T46628-Ab-2 | Anti-Canine MTTP monoclonal antibody | Canine |
GM-Tg-bovg-T46628-Ab-1/ GM-Tg-bovg-T46628-Ab-2 | Anti-Bovine MTTP monoclonal antibody | Bovine |
GM-Tg-equg-T46628-Ab-1/ GM-Tg-equg-T46628-Ab-2 | Anti-Equine MTTP monoclonal antibody | Equine |
Size: 1mg | 10mg | 100mg
Product Description
Catalog No. | GM-Tg-hg-T46628-Ab-1/ GM-Tg-hg-T46628-Ab-2; GM-Tg-rg-T46628-Ab-1/ GM-Tg-rg-T46628-Ab-2; GM-Tg-mg-T46628-Ab-1/ GM-Tg-mg-T46628-Ab-2; GM-Tg-cynog-T46628-Ab-1/ GM-Tg-cynog-T46628-Ab-2; GM-Tg-felg-T46628-Ab-1/ GM-Tg-felg-T46628-Ab-2; GM-Tg-cang-T46628-Ab-1/ GM-Tg-cang-T46628-Ab-2; GM-Tg-bovg-T46628-Ab-1/ GM-Tg-bovg-T46628-Ab-2; GM-Tg-equg-T46628-Ab-1/ GM-Tg-equg-T46628-Ab-2 |
Products Name | Anti-MTTP monoclonal antibody |
Format | mab |
Target Name | MTTP |
Protein Sub-location | Secreted Protein/Potential Cytokines |
Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
Derivation (species) | Mouse |
CH1+2+3 Isotype (Receptor identification) | IgG |
Type of Light Chain (VD-LC) | N/A |
Expression platform | Mammalian Expression |
Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
Tag | Fc |
Products description | Pre-made anti-MTTP benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
Purity | Purity: ≥95% (SDS-PAGE) |
Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
Category | Cat No. | Products Name |
Target Antigen | GM-Tg-g-T46628-Ag-1 | Recombinant multi-species MTP/ MTTP/ ABL protein |
ORF Viral Vector | pGMLPm004722 | mouse Mttp Lentivirus plasmid |
ORF Viral Vector | vGMLPm004722 | mouse Mttp Lentivirus particle |
Target information
Target ID | GM-T46628 |
Target Name | MTTP |
Gene ID | 4547,17777,310900,708832,487873,101087920,280868,100053803 |
Gene Symbol and Synonyms | 1810043K16Rik,ABL,MTP,MTTP |
Uniprot Accession | P55157,D4A1W8,P55156 |
Uniprot Entry Name | MTP_HUMAN,MTP_RAT,MTP_BOVIN |
Protein Sub-location | Secreted Protein/Potential Cytokines |
Category | Therapeutics Target |
Disease | N/A |
Gene Ensembl | ENSG00000138823 |
Target Classification | N/A |
The target: MTTP, gene name: MTTP, also named as ABL, MTP. MTP encodes the large subunit of the heterodimeric microsomal triglyceride transfer protein. Protein disulfide isomerase (PDI) completes the heterodimeric microsomal triglyceride transfer protein, which has been shown to play a central role in lipoprotein assembly. Mutations in MTP can cause abetalipoproteinemia. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.