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Anti-P2Y12/ P2RY12/ ADPG-R monoclonal antibody
Anti-P2Y12/ P2RY12/ ADPG-R antibody for FACS & in-vivo assay
Go to P2RY12/P2RY12 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T46937-Ab-1/ GM-Tg-hg-T46937-Ab-2 | Anti-Human P2RY12 monoclonal antibody | Human |
| GM-Tg-rg-T46937-Ab-1/ GM-Tg-rg-T46937-Ab-2 | Anti-Rat P2RY12 monoclonal antibody | Rat |
| GM-Tg-mg-T46937-Ab-1/ GM-Tg-mg-T46937-Ab-2 | Anti-Mouse P2RY12 monoclonal antibody | Mouse |
| GM-Tg-cynog-T46937-Ab-1/ GM-Tg-cynog-T46937-Ab-2 | Anti-Cynomolgus/ Rhesus macaque P2RY12 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T46937-Ab-1/ GM-Tg-felg-T46937-Ab-2 | Anti-Feline P2RY12 monoclonal antibody | Feline |
| GM-Tg-cang-T46937-Ab-1/ GM-Tg-cang-T46937-Ab-2 | Anti-Canine P2RY12 monoclonal antibody | Canine |
| GM-Tg-bovg-T46937-Ab-1/ GM-Tg-bovg-T46937-Ab-2 | Anti-Bovine P2RY12 monoclonal antibody | Bovine |
| GM-Tg-equg-T46937-Ab-1/ GM-Tg-equg-T46937-Ab-2 | Anti-Equine P2RY12 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T46937-Ab-1/ GM-Tg-hg-T46937-Ab-2; GM-Tg-rg-T46937-Ab-1/ GM-Tg-rg-T46937-Ab-2; GM-Tg-mg-T46937-Ab-1/ GM-Tg-mg-T46937-Ab-2; GM-Tg-cynog-T46937-Ab-1/ GM-Tg-cynog-T46937-Ab-2; GM-Tg-felg-T46937-Ab-1/ GM-Tg-felg-T46937-Ab-2; GM-Tg-cang-T46937-Ab-1/ GM-Tg-cang-T46937-Ab-2; GM-Tg-bovg-T46937-Ab-1/ GM-Tg-bovg-T46937-Ab-2; GM-Tg-equg-T46937-Ab-1/ GM-Tg-equg-T46937-Ab-2 |
| Products Name | Anti-P2RY12 monoclonal antibody |
| Format | mab |
| Target Name | P2RY12 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-P2RY12 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species P2Y12/ P2RY12/ ADPG-R VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | vGMLP003557 | human P2RY12 Lentivirus particle |
| ORF Viral Vector | pGMLP003557 | human P2RY12 Lentivirus plasmid |
Target information
| Target ID | GM-T46937 |
| Target Name | P2RY12 |
| Gene ID | 64805,70839,64803,710036,442958,101094044,408007,100630046 |
| Gene Symbol and Synonyms | 2900079B22Rik,4921504D23Rik,ADPG-R,BDPLT8,HORK3,P2RY12,P2T(AC),P2Y(12)R,P2Y(AC),P2Y(ADP),P2Y(cyc),P2Y12,SP1999 |
| Uniprot Accession | Q9H244,Q9EPX4 |
| Uniprot Entry Name | P2Y12_HUMAN,P2Y12_RAT |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000169313 |
| Target Classification | GPCR |
The target: P2RY12, gene name: P2RY12, also named as ADPG-R, BDPLT8, HORK3, P2T(AC), P2Y(12)R, P2Y(AC), P2Y(ADP), P2Y(cyc), P2Y12, SP1999. The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is involved in platelet aggregation, and is a potential target for the treatment of thromboembolisms and other clotting disorders. Mutations in this gene are implicated in bleeding disorder, platelet type 8 (BDPLT8). Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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