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Anti-VMAT2/ SLC18A2/ PKDYS2 monoclonal antibody
Anti-VMAT2/ SLC18A2/ PKDYS2 antibody for FACS & in-vivo assay
Go to SLC18A2/SLC18A2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T48873-Ab-1/ GM-Tg-hg-T48873-Ab-2 | Anti-Human SLC18A2 monoclonal antibody | Human |
| GM-Tg-rg-T48873-Ab-1/ GM-Tg-rg-T48873-Ab-2 | Anti-Rat SLC18A2 monoclonal antibody | Rat |
| GM-Tg-mg-T48873-Ab-1/ GM-Tg-mg-T48873-Ab-2 | Anti-Mouse SLC18A2 monoclonal antibody | Mouse |
| GM-Tg-cynog-T48873-Ab-1/ GM-Tg-cynog-T48873-Ab-2 | Anti-Cynomolgus/ Rhesus macaque SLC18A2 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T48873-Ab-1/ GM-Tg-felg-T48873-Ab-2 | Anti-Feline SLC18A2 monoclonal antibody | Feline |
| GM-Tg-cang-T48873-Ab-1/ GM-Tg-cang-T48873-Ab-2 | Anti-Canine SLC18A2 monoclonal antibody | Canine |
| GM-Tg-bovg-T48873-Ab-1/ GM-Tg-bovg-T48873-Ab-2 | Anti-Bovine SLC18A2 monoclonal antibody | Bovine |
| GM-Tg-equg-T48873-Ab-1/ GM-Tg-equg-T48873-Ab-2 | Anti-Equine SLC18A2 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T48873-Ab-1/ GM-Tg-hg-T48873-Ab-2; GM-Tg-rg-T48873-Ab-1/ GM-Tg-rg-T48873-Ab-2; GM-Tg-mg-T48873-Ab-1/ GM-Tg-mg-T48873-Ab-2; GM-Tg-cynog-T48873-Ab-1/ GM-Tg-cynog-T48873-Ab-2; GM-Tg-felg-T48873-Ab-1/ GM-Tg-felg-T48873-Ab-2; GM-Tg-cang-T48873-Ab-1/ GM-Tg-cang-T48873-Ab-2; GM-Tg-bovg-T48873-Ab-1/ GM-Tg-bovg-T48873-Ab-2; GM-Tg-equg-T48873-Ab-1/ GM-Tg-equg-T48873-Ab-2 |
| Products Name | Anti-SLC18A2 monoclonal antibody |
| Format | mab |
| Target Name | SLC18A2 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-SLC18A2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species VMAT2/ SLC18A2/ PKDYS2 VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | pGMLP000771 | human SLC18A2 Lentivirus plasmid |
| ORF Viral Vector | vGMLP000771 | human SLC18A2 Lentivirus particle |
| ORF Viral Vector | pGMLPm003030 | mouse Slc18a2 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm003030 | mouse Slc18a2 Lentivirus particle |
Target information
| Target ID | GM-T48873 |
| Target Name | SLC18A2 |
| Gene ID | 6571,214084,25549,701133,486908,101086507,282471,100058805 |
| Gene Symbol and Synonyms | 1110037L13Rik,9330105E13,MNAT,PKDYS2,SLC18A2,SVAT,SVMT,VAT2,VMAT-2,VMAT2 |
| Uniprot Accession | Q05940,Q01827,Q27963 |
| Uniprot Entry Name | VMAT2_HUMAN,VMAT2_RAT,VMAT2_BOVIN |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000165646 |
| Target Classification | N/A |
The target: SLC18A2, gene name: SLC18A2, also named as PKDYS2, SVAT, SVMT, VAT2, VMAT2. This gene encodes an transmembrane protein that functions as an ATP-dependent transporter of monoamines, such as dopamine, norepinephrine, serotonin, and histamine. This protein transports amine neurotransmitters into synaptic vesicles. Polymorphisms in this gene may be associated with schizophrenia, bipolar disorder, and other neurological/psychiatric ailments. [provided by RefSeq, Jun 2018].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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