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Anti-KCNQ1/ ATFB1/ ATFB3 monoclonal antibody
Anti-KCNQ1/ ATFB1/ ATFB3 antibody for FACS & in-vivo assay
Go to KCNQ1/KCNQ1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T49526-Ab-1/ GM-Tg-hg-T49526-Ab-2 | Anti-Human KCNQ1 monoclonal antibody | Human |
| GM-Tg-rg-T49526-Ab-1/ GM-Tg-rg-T49526-Ab-2 | Anti-Rat KCNQ1 monoclonal antibody | Rat |
| GM-Tg-mg-T49526-Ab-1/ GM-Tg-mg-T49526-Ab-2 | Anti-Mouse KCNQ1 monoclonal antibody | Mouse |
| GM-Tg-cynog-T49526-Ab-1/ GM-Tg-cynog-T49526-Ab-2 | Anti-Cynomolgus/ Rhesus macaque KCNQ1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T49526-Ab-1/ GM-Tg-felg-T49526-Ab-2 | Anti-Feline KCNQ1 monoclonal antibody | Feline |
| GM-Tg-cang-T49526-Ab-1/ GM-Tg-cang-T49526-Ab-2 | Anti-Canine KCNQ1 monoclonal antibody | Canine |
| GM-Tg-bovg-T49526-Ab-1/ GM-Tg-bovg-T49526-Ab-2 | Anti-Bovine KCNQ1 monoclonal antibody | Bovine |
| GM-Tg-equg-T49526-Ab-1/ GM-Tg-equg-T49526-Ab-2 | Anti-Equine KCNQ1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T49526-Ab-1/ GM-Tg-hg-T49526-Ab-2; GM-Tg-rg-T49526-Ab-1/ GM-Tg-rg-T49526-Ab-2; GM-Tg-mg-T49526-Ab-1/ GM-Tg-mg-T49526-Ab-2; GM-Tg-cynog-T49526-Ab-1/ GM-Tg-cynog-T49526-Ab-2; GM-Tg-felg-T49526-Ab-1/ GM-Tg-felg-T49526-Ab-2; GM-Tg-cang-T49526-Ab-1/ GM-Tg-cang-T49526-Ab-2; GM-Tg-bovg-T49526-Ab-1/ GM-Tg-bovg-T49526-Ab-2; GM-Tg-equg-T49526-Ab-1/ GM-Tg-equg-T49526-Ab-2 |
| Products Name | Anti-KCNQ1 monoclonal antibody |
| Format | mab |
| Target Name | KCNQ1 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-KCNQ1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species KCNQ1/ ATFB1/ ATFB3 VLP (virus-like particle) (Products Developing) |
Target information
| Target ID | GM-T49526 |
| Target Name | KCNQ1 |
| Gene ID | 3784,16535,84020,721211,483669,101092644,784876,100060336 |
| Gene Symbol and Synonyms | ATFB1,ATFB3,JLNS1,KCNA8,KCNA9,KCNQ1,Kv1.9,Kv7.1,KVLQT1,LQT,LQT1,RWS,SQT2,WRS |
| Uniprot Accession | P51787,Q9Z0N7,O97531 |
| Uniprot Entry Name | KCNQ1_HUMAN,KCNQ1_RAT,KCNQ1_FELCA |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000053918 |
| Target Classification | Ion Channel |
The target: KCNQ1, gene name: KCNQ1, also named as ATFB1, ATFB3, JLNS1, KCNA8, KCNA9, KVLQT1, Kv1.9, Kv7.1, LQT, LQT1, RWS, SQT2, WRS. This gene encodes a voltage-gated potassium channel required for repolarization phase of the cardiac action potential. This protein can form heteromultimers with two other potassium channel proteins, KCNE1 and KCNE3. Mutations in this gene are associated with hereditary long QT syndrome 1 (also known as Romano-Ward syndrome), Jervell and Lange-Nielsen syndrome, and familial atrial fibrillation. This gene exhibits tissue-specific imprinting, with preferential expression from the maternal allele in some tissues, and biallelic expression in others. This gene is located in a region of chromosome 11 amongst other imprinted genes that are associated with Beckwith-Wiedemann syndrome (BWS), and itself has been shown to be disrupted by chromosomal rearrangements in patients with BWS. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2011].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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