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Anti-CAC1C/ CACNA1C/ CACH2 monoclonal antibody
Anti-CAC1C/ CACNA1C/ CACH2 antibody for FACS & in-vivo assay
Go to CACNA1C/CACNA1C products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T51115-Ab-1/ GM-Tg-hg-T51115-Ab-2 | Anti-Human CACNA1C monoclonal antibody | Human |
| GM-Tg-rg-T51115-Ab-1/ GM-Tg-rg-T51115-Ab-2 | Anti-Rat CACNA1C monoclonal antibody | Rat |
| GM-Tg-mg-T51115-Ab-1/ GM-Tg-mg-T51115-Ab-2 | Anti-Mouse CACNA1C monoclonal antibody | Mouse |
| GM-Tg-cynog-T51115-Ab-1/ GM-Tg-cynog-T51115-Ab-2 | Anti-Cynomolgus/ Rhesus macaque CACNA1C monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T51115-Ab-1/ GM-Tg-felg-T51115-Ab-2 | Anti-Feline CACNA1C monoclonal antibody | Feline |
| GM-Tg-cang-T51115-Ab-1/ GM-Tg-cang-T51115-Ab-2 | Anti-Canine CACNA1C monoclonal antibody | Canine |
| GM-Tg-bovg-T51115-Ab-1/ GM-Tg-bovg-T51115-Ab-2 | Anti-Bovine CACNA1C monoclonal antibody | Bovine |
| GM-Tg-equg-T51115-Ab-1/ GM-Tg-equg-T51115-Ab-2 | Anti-Equine CACNA1C monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T51115-Ab-1/ GM-Tg-hg-T51115-Ab-2; GM-Tg-rg-T51115-Ab-1/ GM-Tg-rg-T51115-Ab-2; GM-Tg-mg-T51115-Ab-1/ GM-Tg-mg-T51115-Ab-2; GM-Tg-cynog-T51115-Ab-1/ GM-Tg-cynog-T51115-Ab-2; GM-Tg-felg-T51115-Ab-1/ GM-Tg-felg-T51115-Ab-2; GM-Tg-cang-T51115-Ab-1/ GM-Tg-cang-T51115-Ab-2; GM-Tg-bovg-T51115-Ab-1/ GM-Tg-bovg-T51115-Ab-2; GM-Tg-equg-T51115-Ab-1/ GM-Tg-equg-T51115-Ab-2 |
| Products Name | Anti-CACNA1C monoclonal antibody |
| Format | mab |
| Target Name | CACNA1C |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-CACNA1C benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species CAC1C/ CACNA1C/ CACH2 VLP (virus-like particle) (Products Developing) |
Target information
| Target ID | GM-T51115 |
| Target Name | CACNA1C |
| Gene ID | 775,12288,24239,721721,403516,101082923,408015,100049924 |
| Gene Symbol and Synonyms | CACH2,CACN2,CACNA1C,CACNA1C-IT2,CACNL1A1,CaV1.2,CCHL1A1,D930026N18Rik,ICA,LQT8,MBC,MELC-CC,NEDHLSS,RATIVS302,TS,TS. LQT8 |
| Uniprot Accession | Q13936,P22002 |
| Uniprot Entry Name | CAC1C_HUMAN,CAC1C_RAT |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000151067 |
| Target Classification | N/A |
The target: CACNA1C, gene name: CACNA1C, also named as CACH2, CACN2, CACNL1A1, CCHL1A1, CaV1.2, LQT8, TS. This gene encodes an alpha-1 subunit of a voltage-dependent calcium channel. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization. The alpha-1 subunit consists of 24 transmembrane segments and forms the pore through which ions pass into the cell. The calcium channel consists of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. There are multiple isoforms of each of these proteins, either encoded by different genes or the result of alternative splicing of transcripts. The protein encoded by this gene binds to and is inhibited by dihydropyridine. Alternative splicing results in many transcript variants encoding different proteins. Some of the predicted proteins may not produce functional ion channel subunits. [provided by RefSeq, Oct 2012].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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