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Anti-PERT/ TPO/ MSA monoclonal antibody
Anti-PERT/ TPO/ MSA antibody for FACS & in-vivo assay
Go to TPO/TPO products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T51120-Ab-1/ GM-Tg-hg-T51120-Ab-2 | Anti-Human TPO monoclonal antibody | Human |
| GM-Tg-rg-T51120-Ab-1/ GM-Tg-rg-T51120-Ab-2 | Anti-Rat TPO monoclonal antibody | Rat |
| GM-Tg-mg-T51120-Ab-1/ GM-Tg-mg-T51120-Ab-2 | Anti-Mouse TPO monoclonal antibody | Mouse |
| GM-Tg-cynog-T51120-Ab-1/ GM-Tg-cynog-T51120-Ab-2 | Anti-Cynomolgus/ Rhesus macaque TPO monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T51120-Ab-1/ GM-Tg-felg-T51120-Ab-2 | Anti-Feline TPO monoclonal antibody | Feline |
| GM-Tg-cang-T51120-Ab-1/ GM-Tg-cang-T51120-Ab-2 | Anti-Canine TPO monoclonal antibody | Canine |
| GM-Tg-bovg-T51120-Ab-1/ GM-Tg-bovg-T51120-Ab-2 | Anti-Bovine TPO monoclonal antibody | Bovine |
| GM-Tg-equg-T51120-Ab-1/ GM-Tg-equg-T51120-Ab-2 | Anti-Equine TPO monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T51120-Ab-1/ GM-Tg-hg-T51120-Ab-2; GM-Tg-rg-T51120-Ab-1/ GM-Tg-rg-T51120-Ab-2; GM-Tg-mg-T51120-Ab-1/ GM-Tg-mg-T51120-Ab-2; GM-Tg-cynog-T51120-Ab-1/ GM-Tg-cynog-T51120-Ab-2; GM-Tg-felg-T51120-Ab-1/ GM-Tg-felg-T51120-Ab-2; GM-Tg-cang-T51120-Ab-1/ GM-Tg-cang-T51120-Ab-2; GM-Tg-bovg-T51120-Ab-1/ GM-Tg-bovg-T51120-Ab-2; GM-Tg-equg-T51120-Ab-1/ GM-Tg-equg-T51120-Ab-2 |
| Products Name | Anti-TPO monoclonal antibody |
| Format | mab |
| Target Name | TPO |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody, Diagnostic target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-TPO benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species PERT/ TPO/ MSA VLP (virus-like particle) (Products Developing) |
Target information
| Target ID | GM-T51120 |
| Target Name | TPO |
| Gene ID | 7173,22018,54314,721610,403521,101098706,525013,100072955 |
| Gene Symbol and Synonyms | MSA,TDH2A,TPO,TPX |
| Uniprot Accession | P07202,P14650,Q8HYB7 |
| Uniprot Entry Name | PERT_HUMAN,PERT_RAT,PERT_CANLF |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target, Diagnostics Biomarker |
| Disease | N/A |
| Gene Ensembl | ENSG00000115705 |
| Target Classification | N/A |
The target: TPO, gene name: TPO, also named as MSA, TDH2A, TPX. This gene encodes a membrane-bound glycoprotein. The encoded protein acts as an enzyme and plays a central role in thyroid gland function. The protein functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid hormones, thyroxine and triiodothyronine. Mutations in this gene are associated with several disorders of thyroid hormonogenesis, including congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA. Multiple transcript variants encoding distinct isoforms have been identified for this gene, but the full-length nature of some variants has not been determined. [provided by RefSeq, May 2011].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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