Anti-ATP4A/ ATP6A monoclonal antibody

Anti-ATP4A/ ATP6A antibody for FACS & in-vivo assay

Target products collectionGo to ATP4A/ATP4A products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T51666-Ab-1/ GM-Tg-hg-T51666-Ab-2Anti-Human ATP4A monoclonal antibodyHuman
GM-Tg-rg-T51666-Ab-1/ GM-Tg-rg-T51666-Ab-2Anti-Rat ATP4A monoclonal antibodyRat
GM-Tg-mg-T51666-Ab-1/ GM-Tg-mg-T51666-Ab-2Anti-Mouse ATP4A monoclonal antibodyMouse
GM-Tg-cynog-T51666-Ab-1/ GM-Tg-cynog-T51666-Ab-2Anti-Cynomolgus/ Rhesus macaque ATP4A monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T51666-Ab-1/ GM-Tg-felg-T51666-Ab-2Anti-Feline ATP4A monoclonal antibodyFeline
GM-Tg-cang-T51666-Ab-1/ GM-Tg-cang-T51666-Ab-2Anti-Canine ATP4A monoclonal antibodyCanine
GM-Tg-bovg-T51666-Ab-1/ GM-Tg-bovg-T51666-Ab-2Anti-Bovine ATP4A monoclonal antibodyBovine
GM-Tg-equg-T51666-Ab-1/ GM-Tg-equg-T51666-Ab-2Anti-Equine ATP4A monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T51666-Ab-1/ GM-Tg-hg-T51666-Ab-2; GM-Tg-rg-T51666-Ab-1/ GM-Tg-rg-T51666-Ab-2;
GM-Tg-mg-T51666-Ab-1/ GM-Tg-mg-T51666-Ab-2; GM-Tg-cynog-T51666-Ab-1/ GM-Tg-cynog-T51666-Ab-2;
GM-Tg-felg-T51666-Ab-1/ GM-Tg-felg-T51666-Ab-2; GM-Tg-cang-T51666-Ab-1/ GM-Tg-cang-T51666-Ab-2;
GM-Tg-bovg-T51666-Ab-1/ GM-Tg-bovg-T51666-Ab-2; GM-Tg-equg-T51666-Ab-1/ GM-Tg-equg-T51666-Ab-2
Products NameAnti-ATP4A monoclonal antibody
Formatmab
Target NameATP4A
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-ATP4A benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species ATP4A/ ATP6A VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-T51666
    Target NameATP4A
    Gene ID495,11944,24216,100426215,431686,101100771,521163,100147108
    Gene Symbol and SynonymsATP4A,ATP6A,Hka,Hkatpc
    Uniprot AccessionP20648,P09626,P50996
    Uniprot Entry NameATP4A_HUMAN,ATP4A_RAT,ATP4A_CANLF
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target
    DiseaseN/A
    Gene EnsemblENSG00000105675
    Target ClassificationN/A

    The target: ATP4A, gene name: ATP4A, also named as ATP6A. The protein encoded by this gene belongs to a family of P-type cation-transporting ATPases. The gastric H+, K+-ATPase is a heterodimer consisting of a high molecular weight catalytic alpha subunit and a smaller but heavily glycosylated beta subunit. This enzyme is a proton pump that catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. It is also responsible for gastric acid secretion. This gene encodes a catalytic alpha subunit of the gastric H+, K+-ATPase. [provided by RefSeq, Jul 2008].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.