Anti-ACLY/ ACL/ ATPCL monoclonal antibody

Anti-ACLY/ ACL/ ATPCL antibody for FACS & in-vivo assay

Target products collectionGo to ACLY/ACLY products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)


Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T52189-Ab-1/ GM-Tg-hg-T52189-Ab-2Anti-Human ACLY monoclonal antibodyHuman
GM-Tg-rg-T52189-Ab-1/ GM-Tg-rg-T52189-Ab-2Anti-Rat ACLY monoclonal antibodyRat
GM-Tg-mg-T52189-Ab-1/ GM-Tg-mg-T52189-Ab-2Anti-Mouse ACLY monoclonal antibodyMouse
GM-Tg-cynog-T52189-Ab-1/ GM-Tg-cynog-T52189-Ab-2Anti-Cynomolgus/ Rhesus macaque ACLY monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T52189-Ab-1/ GM-Tg-felg-T52189-Ab-2Anti-Feline ACLY monoclonal antibodyFeline
GM-Tg-cang-T52189-Ab-1/ GM-Tg-cang-T52189-Ab-2Anti-Canine ACLY monoclonal antibodyCanine
GM-Tg-bovg-T52189-Ab-1/ GM-Tg-bovg-T52189-Ab-2Anti-Bovine ACLY monoclonal antibodyBovine
GM-Tg-equg-T52189-Ab-1/ GM-Tg-equg-T52189-Ab-2Anti-Equine ACLY monoclonal antibodyEquine

Size: 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T52189-Ab-1/ GM-Tg-hg-T52189-Ab-2; GM-Tg-rg-T52189-Ab-1/ GM-Tg-rg-T52189-Ab-2;
GM-Tg-mg-T52189-Ab-1/ GM-Tg-mg-T52189-Ab-2; GM-Tg-cynog-T52189-Ab-1/ GM-Tg-cynog-T52189-Ab-2;
GM-Tg-felg-T52189-Ab-1/ GM-Tg-felg-T52189-Ab-2; GM-Tg-cang-T52189-Ab-1/ GM-Tg-cang-T52189-Ab-2;
GM-Tg-bovg-T52189-Ab-1/ GM-Tg-bovg-T52189-Ab-2; GM-Tg-equg-T52189-Ab-1/ GM-Tg-equg-T52189-Ab-2
Products NameAnti-ACLY monoclonal antibody
Formatmab
Target NameACLY
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)
IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-ACLY benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species ACLY/ ACL/ ATPCL VLP (virus-like particle) (Products Developing)
    ORF Viral VectorvGMLP005159human ACLY Lentivirus particle
    ORF Viral VectorpGMLP005159human ACLY Lentivirus plasmid


    Target information

    Target IDGM-T52189
    Target NameACLY
    Gene ID47,104112,24159,708501,607852,100422779,511135,100053195
    Gene Symbol and SynonymsA730098H14Rik,ACL,ACLY,ATPCL,CLATP
    Uniprot AccessionP53396,P16638,Q32PF2
    Uniprot Entry NameACLY_HUMAN,ACLY_RAT,ACLY_BOVIN
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target
    DiseaseN/A
    Gene EnsemblENSG00000131473
    Target ClassificationN/A

    The target: ACLY, gene name: ACLY, also named as ACL, ATPCL, CLATP. ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440,000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Dec 2014].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.