Anti-CASP4/ ICE(rel)II/ ICEREL-II monoclonal antibody
Anti-CASP4/ ICE(rel)II/ ICEREL-II antibody for FACS & in-vivo assay
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(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
Product information
Catalog No. | Product Name | Species Reactivity |
---|---|---|
GM-Tg-hg-T53469-Ab-1/ GM-Tg-hg-T53469-Ab-2 | Anti-Human CASP4 monoclonal antibody | Human |
GM-Tg-rg-T53469-Ab-1/ GM-Tg-rg-T53469-Ab-2 | Anti-Rat CASP4 monoclonal antibody | Rat |
GM-Tg-mg-T53469-Ab-1/ GM-Tg-mg-T53469-Ab-2 | Anti-Mouse CASP4 monoclonal antibody | Mouse |
GM-Tg-cynog-T53469-Ab-1/ GM-Tg-cynog-T53469-Ab-2 | Anti-Cynomolgus/ Rhesus macaque CASP4 monoclonal antibody | Cynomolgus/ Rhesus macaque |
GM-Tg-felg-T53469-Ab-1/ GM-Tg-felg-T53469-Ab-2 | Anti-Feline CASP4 monoclonal antibody | Feline |
GM-Tg-cang-T53469-Ab-1/ GM-Tg-cang-T53469-Ab-2 | Anti-Canine CASP4 monoclonal antibody | Canine |
GM-Tg-bovg-T53469-Ab-1/ GM-Tg-bovg-T53469-Ab-2 | Anti-Bovine CASP4 monoclonal antibody | Bovine |
GM-Tg-equg-T53469-Ab-1/ GM-Tg-equg-T53469-Ab-2 | Anti-Equine CASP4 monoclonal antibody | Equine |
Size: 1mg | 10mg | 100mg
Product Description
Catalog No. | GM-Tg-hg-T53469-Ab-1/ GM-Tg-hg-T53469-Ab-2; GM-Tg-rg-T53469-Ab-1/ GM-Tg-rg-T53469-Ab-2; GM-Tg-mg-T53469-Ab-1/ GM-Tg-mg-T53469-Ab-2; GM-Tg-cynog-T53469-Ab-1/ GM-Tg-cynog-T53469-Ab-2; GM-Tg-felg-T53469-Ab-1/ GM-Tg-felg-T53469-Ab-2; GM-Tg-cang-T53469-Ab-1/ GM-Tg-cang-T53469-Ab-2; GM-Tg-bovg-T53469-Ab-1/ GM-Tg-bovg-T53469-Ab-2; GM-Tg-equg-T53469-Ab-1/ GM-Tg-equg-T53469-Ab-2 |
Products Name | Anti-CASP4 monoclonal antibody |
Format | mab |
Target Name | CASP4 |
Protein Sub-location | Transmembrane Protein |
Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
Derivation (species) | Mouse |
CH1+2+3 Isotype (Receptor identification) | IgG |
Type of Light Chain (VD-LC) | N/A |
Expression platform | Mammalian Expression |
Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
Tag | Fc |
Products description | Pre-made anti-CASP4 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
Purity | Purity: ≥95% (SDS-PAGE) |
Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
Category | Cat No. | Products Name |
Target Antigen | Products Developing | Multi-species CASP4/ ICE(rel)II/ ICEREL-II VLP (virus-like particle) (Products Developing) |
ORF Viral Vector | vGMLP003610 | human CASP4 Lentivirus particle |
ORF Viral Vector | pGMLP003610 | human CASP4 Lentivirus plasmid |
ORF Viral Vector | pGMLPm002309 | mouse Casp4 Lentivirus plasmid |
ORF Viral Vector | vGMLPm002309 | mouse Casp4 Lentivirus particle |
Target information
Target ID | GM-T53469 |
Target Name | CASP4 |
Gene ID | 837,704864 |
Gene Symbol and Synonyms | CASP4,ICE(rel)II,ICEREL-II,ICH-2,Mih1,Mih1/TX,TX |
Uniprot Accession | P49662 |
Uniprot Entry Name | CASP4_HUMAN |
Protein Sub-location | Transmembrane Protein |
Category | Therapeutics Target |
Disease | Cancer |
Gene Ensembl | ENSG00000196954 |
Target Classification | Tumor-associated antigen (TAA) |
The target: CASP4, gene name: CASP4, also named as ICE(rel)II, ICEREL-II, ICH-2, Mih1, Mih1/TX, TX. This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain and a large and small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This caspase is able to cleave and activate its own precursor protein, as well as caspase 1 precursor. When overexpressed, this gene induces cell apoptosis. Alternative splicing results in transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.