Anti-CAC1H/ CACNA1H/ CACNA1HB monoclonal antibody
Anti-CAC1H/ CACNA1H/ CACNA1HB antibody for FACS & in-vivo assay
Go to CACNA1H/CACNA1H products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
Product information
Catalog No. | Product Name | Species Reactivity |
---|---|---|
GM-Tg-hg-T54644-Ab-1/ GM-Tg-hg-T54644-Ab-2 | Anti-Human CACNA1H monoclonal antibody | Human |
GM-Tg-rg-T54644-Ab-1/ GM-Tg-rg-T54644-Ab-2 | Anti-Rat CACNA1H monoclonal antibody | Rat |
GM-Tg-mg-T54644-Ab-1/ GM-Tg-mg-T54644-Ab-2 | Anti-Mouse CACNA1H monoclonal antibody | Mouse |
GM-Tg-cynog-T54644-Ab-1/ GM-Tg-cynog-T54644-Ab-2 | Anti-Cynomolgus/ Rhesus macaque CACNA1H monoclonal antibody | Cynomolgus/ Rhesus macaque |
GM-Tg-felg-T54644-Ab-1/ GM-Tg-felg-T54644-Ab-2 | Anti-Feline CACNA1H monoclonal antibody | Feline |
GM-Tg-cang-T54644-Ab-1/ GM-Tg-cang-T54644-Ab-2 | Anti-Canine CACNA1H monoclonal antibody | Canine |
GM-Tg-bovg-T54644-Ab-1/ GM-Tg-bovg-T54644-Ab-2 | Anti-Bovine CACNA1H monoclonal antibody | Bovine |
GM-Tg-equg-T54644-Ab-1/ GM-Tg-equg-T54644-Ab-2 | Anti-Equine CACNA1H monoclonal antibody | Equine |
Size: 1mg | 10mg | 100mg
Product Description
Catalog No. | GM-Tg-hg-T54644-Ab-1/ GM-Tg-hg-T54644-Ab-2; GM-Tg-rg-T54644-Ab-1/ GM-Tg-rg-T54644-Ab-2; GM-Tg-mg-T54644-Ab-1/ GM-Tg-mg-T54644-Ab-2; GM-Tg-cynog-T54644-Ab-1/ GM-Tg-cynog-T54644-Ab-2; GM-Tg-felg-T54644-Ab-1/ GM-Tg-felg-T54644-Ab-2; GM-Tg-cang-T54644-Ab-1/ GM-Tg-cang-T54644-Ab-2; GM-Tg-bovg-T54644-Ab-1/ GM-Tg-bovg-T54644-Ab-2; GM-Tg-equg-T54644-Ab-1/ GM-Tg-equg-T54644-Ab-2 |
Products Name | Anti-CACNA1H monoclonal antibody |
Format | mab |
Target Name | CACNA1H |
Protein Sub-location | Transmembrane Protein |
Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
Derivation (species) | Mouse |
CH1+2+3 Isotype (Receptor identification) | IgG |
Type of Light Chain (VD-LC) | N/A |
Expression platform | Mammalian Expression |
Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
Tag | Fc |
Products description | Pre-made anti-CACNA1H benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
Purity | Purity: ≥95% (SDS-PAGE) |
Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
Category | Cat No. | Products Name |
Target Antigen | Products Developing | Multi-species CAC1H/ CACNA1H/ CACNA1HB VLP (virus-like particle) (Products Developing) |
Target information
Target ID | GM-T54644 |
Target Name | CACNA1H |
Gene ID | 8912,58226,114862,722407,403533,101090071,282412,100067492 |
Gene Symbol and Synonyms | alpha13.2,CACNA1H,CACNA1HB,Cav3.2,ECA6,EIG6,HALD4,MNCb-1209 |
Uniprot Accession | O95180,Q9EQ60 |
Uniprot Entry Name | CAC1H_HUMAN,CAC1H_RAT |
Protein Sub-location | Transmembrane Protein |
Category | Therapeutics Target |
Disease | N/A |
Gene Ensembl | ENSG00000196557 |
Target Classification | Ion Channel |
The target: CACNA1H, gene name: CACNA1H, also named as CACNA1HB, Cav3.2, ECA6, EIG6, HALD4. This gene encodes a T-type member of the alpha-1 subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. The alpha-1 subunit has 24 transmembrane segments and forms the pore through which ions pass into the cell. There are multiple isoforms of each of the proteins in the complex, either encoded by different genes or the result of alternative splicing of transcripts. Alternate transcriptional splice variants, encoding different isoforms, have been characterized for the gene described here. Studies suggest certain mutations in this gene lead to childhood absence epilepsy (CAE). [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.