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Anti-ACHA2/ CHRNA2 monoclonal antibody
Anti-ACHA2/ CHRNA2 antibody for FACS & in-vivo assay
Go to CHRNA2/CHRNA2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T55815-Ab-1/ GM-Tg-hg-T55815-Ab-2 | Anti-Human CHRNA2 monoclonal antibody | Human |
| GM-Tg-rg-T55815-Ab-1/ GM-Tg-rg-T55815-Ab-2 | Anti-Rat CHRNA2 monoclonal antibody | Rat |
| GM-Tg-mg-T55815-Ab-1/ GM-Tg-mg-T55815-Ab-2 | Anti-Mouse CHRNA2 monoclonal antibody | Mouse |
| GM-Tg-cynog-T55815-Ab-1/ GM-Tg-cynog-T55815-Ab-2 | Anti-Cynomolgus/ Rhesus macaque CHRNA2 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T55815-Ab-1/ GM-Tg-felg-T55815-Ab-2 | Anti-Feline CHRNA2 monoclonal antibody | Feline |
| GM-Tg-cang-T55815-Ab-1/ GM-Tg-cang-T55815-Ab-2 | Anti-Canine CHRNA2 monoclonal antibody | Canine |
| GM-Tg-bovg-T55815-Ab-1/ GM-Tg-bovg-T55815-Ab-2 | Anti-Bovine CHRNA2 monoclonal antibody | Bovine |
| GM-Tg-equg-T55815-Ab-1/ GM-Tg-equg-T55815-Ab-2 | Anti-Equine CHRNA2 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T55815-Ab-1/ GM-Tg-hg-T55815-Ab-2; GM-Tg-rg-T55815-Ab-1/ GM-Tg-rg-T55815-Ab-2; GM-Tg-mg-T55815-Ab-1/ GM-Tg-mg-T55815-Ab-2; GM-Tg-cynog-T55815-Ab-1/ GM-Tg-cynog-T55815-Ab-2; GM-Tg-felg-T55815-Ab-1/ GM-Tg-felg-T55815-Ab-2; GM-Tg-cang-T55815-Ab-1/ GM-Tg-cang-T55815-Ab-2; GM-Tg-bovg-T55815-Ab-1/ GM-Tg-bovg-T55815-Ab-2; GM-Tg-equg-T55815-Ab-1/ GM-Tg-equg-T55815-Ab-2 |
| Products Name | Anti-CHRNA2 monoclonal antibody |
| Format | mab |
| Target Name | CHRNA2 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-CHRNA2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species ACHA2/ CHRNA2 VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | vGMLP001473 | human CHRNA2 Lentivirus particle |
| ORF Viral Vector | pGMLP001473 | human CHRNA2 Lentivirus plasmid |
| ORF Viral Vector | pGMLPm004834 | mouse Chrna2 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm004834 | mouse Chrna2 Lentivirus particle |
Target information
| Target ID | GM-T55815 |
| Target Name | CHRNA2 |
| Gene ID | 1135,110902,170945,712868,486101,101092104,531838,100060380 |
| Gene Symbol and Synonyms | ACHR,Acra-2,Acra2,CHRNA2,nica2 |
| Uniprot Accession | Q15822,P12389 |
| Uniprot Entry Name | ACHA2_HUMAN,ACHA2_RAT |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000120903 |
| Target Classification | N/A |
The target: CHRNA2, gene name: CHRNA2, also named as . Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels formed by a pentameric arrangement of alpha and beta subunits to create distinct muscle and neuronal receptors. Neuronal receptors are found throughout the peripheral and central nervous system where they are involved in fast synaptic transmission. This gene encodes an alpha subunit that is widely expressed in the brain. The proposed structure for nAChR subunits is a conserved N-terminal extracellular domain followed by three conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region. Mutations in this gene cause autosomal dominant nocturnal frontal lobe epilepsy type 4. Single nucleotide polymorphisms (SNPs) in this gene have been associated with nicotine dependence. [provided by RefSeq, Nov 2009].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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