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Anti-TPP1/ CLN2/ GIG1 functional antibody
Anti-TPP1/ CLN2/ GIG1 functional antibody for cell culture, ELISA & in-vivo assay
Go to TPP1/TPP1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T56262-Ab-1/ GM-Tg-hg-T56262-Ab-2 | Anti-Human TPP1 monoclonal antibody | Human |
| GM-Tg-rg-T56262-Ab-1/ GM-Tg-rg-T56262-Ab-2 | Anti-Rat TPP1 monoclonal antibody | Rat |
| GM-Tg-mg-T56262-Ab-1/ GM-Tg-mg-T56262-Ab-2 | Anti-Mouse TPP1 monoclonal antibody | Mouse |
| GM-Tg-cynog-T56262-Ab-1/ GM-Tg-cynog-T56262-Ab-2 | Anti-Cynomolgus/ Rhesus macaque TPP1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T56262-Ab-1/ GM-Tg-felg-T56262-Ab-2 | Anti-Feline TPP1 monoclonal antibody | Feline |
| GM-Tg-cang-T56262-Ab-1/ GM-Tg-cang-T56262-Ab-2 | Anti-Canine TPP1 monoclonal antibody | Canine |
| GM-Tg-bovg-T56262-Ab-1/ GM-Tg-bovg-T56262-Ab-2 | Anti-Bovine TPP1 monoclonal antibody | Bovine |
| GM-Tg-equg-T56262-Ab-1/ GM-Tg-equg-T56262-Ab-2 | Anti-Equine TPP1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T56262-Ab-1/ GM-Tg-hg-T56262-Ab-2; GM-Tg-rg-T56262-Ab-1/ GM-Tg-rg-T56262-Ab-2; GM-Tg-mg-T56262-Ab-1/ GM-Tg-mg-T56262-Ab-2; GM-Tg-cynog-T56262-Ab-1/ GM-Tg-cynog-T56262-Ab-2; GM-Tg-felg-T56262-Ab-1/ GM-Tg-felg-T56262-Ab-2; GM-Tg-cang-T56262-Ab-1/ GM-Tg-cang-T56262-Ab-2; GM-Tg-bovg-T56262-Ab-1/ GM-Tg-bovg-T56262-Ab-2; GM-Tg-equg-T56262-Ab-1/ GM-Tg-equg-T56262-Ab-2 |
| Products Name | Anti-TPP1 monoclonal antibody |
| Format | mab |
| Target Name | TPP1 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-TPP1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T56262-Ag-1 | Recombinant multi-species TPP1/ CLN2/ GIG1 protein |
| ORF Viral Vector | pGMLP002827 | human TPP1 Lentivirus plasmid |
| ORF Viral Vector | vGMLP002827 | human TPP1 Lentivirus particle |
| ORF Viral Vector | pGMLPm002751 | mouse Tpp1 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm002751 | mouse Tpp1 Lentivirus particle |
Target information
| Target ID | GM-T56262 |
| Target Name | TPP1 |
| Gene ID | 1200,12751,83534,709838,485337,101093296,515575,100070095 |
| Gene Symbol and Synonyms | CLN2,GIG1,LPIC,SCAR7,TPP-1,TPP-I,TPP1 |
| Uniprot Accession | O14773,Q9EQV6,Q9XSB8,Q0V8B6 |
| Uniprot Entry Name | TPP1_HUMAN,TPP1_RAT,TPP1_CANLF,TPP1_BOVIN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | Therapeutics Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000166340 |
| Target Classification | N/A |
The target: TPP1, gene name: TPP1, also named as CLN2, GIG1, LPIC, SCAR7, TPP-1. This gene encodes a member of the sedolisin family of serine proteases. The protease functions in the lysosome to cleave N-terminal tripeptides from substrates, and has weaker endopeptidase activity. It is synthesized as a catalytically-inactive enzyme which is activated and auto-proteolyzed upon acidification. Mutations in this gene result in late-infantile neuronal ceroid lipofuscinosis, which is associated with the failure to degrade specific neuropeptides and a subunit of ATP synthase in the lysosome. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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