Anti-ABCG2/ ABC15/ ABCP monoclonal antibody

Anti-ABCG2/ ABC15/ ABCP antibody for FACS & in-vivo assay

Target products collectionGo to ABCG2/ABCG2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T56556-Ab-1/ GM-Tg-hg-T56556-Ab-2Anti-Human ABCG2 monoclonal antibodyHuman
GM-Tg-rg-T56556-Ab-1/ GM-Tg-rg-T56556-Ab-2Anti-Rat ABCG2 monoclonal antibodyRat
GM-Tg-mg-T56556-Ab-1/ GM-Tg-mg-T56556-Ab-2Anti-Mouse ABCG2 monoclonal antibodyMouse
GM-Tg-cynog-T56556-Ab-1/ GM-Tg-cynog-T56556-Ab-2Anti-Cynomolgus/ Rhesus macaque ABCG2 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T56556-Ab-1/ GM-Tg-felg-T56556-Ab-2Anti-Feline ABCG2 monoclonal antibodyFeline
GM-Tg-cang-T56556-Ab-1/ GM-Tg-cang-T56556-Ab-2Anti-Canine ABCG2 monoclonal antibodyCanine
GM-Tg-bovg-T56556-Ab-1/ GM-Tg-bovg-T56556-Ab-2Anti-Bovine ABCG2 monoclonal antibodyBovine
GM-Tg-equg-T56556-Ab-1/ GM-Tg-equg-T56556-Ab-2Anti-Equine ABCG2 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T56556-Ab-1/ GM-Tg-hg-T56556-Ab-2; GM-Tg-rg-T56556-Ab-1/ GM-Tg-rg-T56556-Ab-2;
GM-Tg-mg-T56556-Ab-1/ GM-Tg-mg-T56556-Ab-2; GM-Tg-cynog-T56556-Ab-1/ GM-Tg-cynog-T56556-Ab-2;
GM-Tg-felg-T56556-Ab-1/ GM-Tg-felg-T56556-Ab-2; GM-Tg-cang-T56556-Ab-1/ GM-Tg-cang-T56556-Ab-2;
GM-Tg-bovg-T56556-Ab-1/ GM-Tg-bovg-T56556-Ab-2; GM-Tg-equg-T56556-Ab-1/ GM-Tg-equg-T56556-Ab-2
Products NameAnti-ABCG2 monoclonal antibody
Formatmab
Target NameABCG2
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-ABCG2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


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    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species ABCG2/ ABC15/ ABCP VLP (virus-like particle) (Products Developing)
    ORF Viral VectorvGMLV000861human ABCG2 Lentivirus particle
    ORF Viral VectorpGMLV000862human ABCG2 Lentivirus plasmid
    ORF Viral VectorpGMLV000231human ABCG2 Lentivirus plasmid
    ORF Viral VectorvGMLV000862human ABCG2 Lentivirus particle
    ORF Viral VectorpGMLV000861human ABCG2 Lentivirus plasmid
    ORF Viral VectorvGMLV000231human ABCG2 Lentivirus particle
    ORF Viral VectorpGMAAV000265Norway rat Abcg2 AAV plasmid
    ORF Viral VectorvGMAAV000265Norway rat Abcg2 AAV particle


    Target information

    Target IDGM-T56556
    Target NameABCG2
    Gene ID9429,26357,312382,574307,478472,101094017,536203,100034164
    Gene Symbol and SynonymsABC15,ABCG2,ABCG3,ABCP,BCRP,BCRP1,BMDP,CD338,CDw338,CDw388,EST157481,GOUT1,MRX,MXR,MXR-1,MXR1,UAQTL1
    Uniprot AccessionQ9UNQ0,Q80W57,Q5MB13,Q4GZT4
    Uniprot Entry NameABCG2_HUMAN,ABCG2_MACMU,ABCG2_RAT,ABCG2_BOVIN
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target
    DiseaseCancer
    Gene EnsemblENSG00000118777
    Target ClassificationTumor-associated antigen (TAA)

    The target: ABCG2, gene name: ABCG2, also named as ABC15, ABCP, BCRP, BCRP1, BMDP, CD338, CDw338, EST157481, GOUT1, MRX, MXR, MXR-1, MXR1, UAQTL1. The membrane-associated protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. Alternatively referred to as a breast cancer resistance protein, this protein functions as a xenobiotic transporter which may play a major role in multi-drug resistance. It likely serves as a cellular defense mechanism in response to mitoxantrone and anthracycline exposure. Significant expression of this protein has been observed in the placenta, which may suggest a potential role for this molecule in placenta tissue. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.