Anti-KIT/ C-Kit/ CD117 monoclonal antibody

Anti-KIT/ C-Kit/ CD117 antibody for FACS & in-vivo assay

Target products collectionGo to KIT/KIT products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)


Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T57700-Ab-1/ GM-Tg-hg-T57700-Ab-2Anti-Human KIT monoclonal antibodyHuman
GM-Tg-rg-T57700-Ab-1/ GM-Tg-rg-T57700-Ab-2Anti-Rat KIT monoclonal antibodyRat
GM-Tg-mg-T57700-Ab-1/ GM-Tg-mg-T57700-Ab-2Anti-Mouse KIT monoclonal antibodyMouse
GM-Tg-cynog-T57700-Ab-1/ GM-Tg-cynog-T57700-Ab-2Anti-Cynomolgus/ Rhesus macaque KIT monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T57700-Ab-1/ GM-Tg-felg-T57700-Ab-2Anti-Feline KIT monoclonal antibodyFeline
GM-Tg-cang-T57700-Ab-1/ GM-Tg-cang-T57700-Ab-2Anti-Canine KIT monoclonal antibodyCanine
GM-Tg-bovg-T57700-Ab-1/ GM-Tg-bovg-T57700-Ab-2Anti-Bovine KIT monoclonal antibodyBovine
GM-Tg-equg-T57700-Ab-1/ GM-Tg-equg-T57700-Ab-2Anti-Equine KIT monoclonal antibodyEquine

Size: 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T57700-Ab-1/ GM-Tg-hg-T57700-Ab-2; GM-Tg-rg-T57700-Ab-1/ GM-Tg-rg-T57700-Ab-2;
GM-Tg-mg-T57700-Ab-1/ GM-Tg-mg-T57700-Ab-2; GM-Tg-cynog-T57700-Ab-1/ GM-Tg-cynog-T57700-Ab-2;
GM-Tg-felg-T57700-Ab-1/ GM-Tg-felg-T57700-Ab-2; GM-Tg-cang-T57700-Ab-1/ GM-Tg-cang-T57700-Ab-2;
GM-Tg-bovg-T57700-Ab-1/ GM-Tg-bovg-T57700-Ab-2; GM-Tg-equg-T57700-Ab-1/ GM-Tg-equg-T57700-Ab-2
Products NameAnti-KIT monoclonal antibody
Formatmab
Target NameKIT
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)
IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-KIT benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


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    Associated products


    CategoryCat No.Products Name
    BiosimilarGMP-Bios-ab-657Pre-Made Barzolvolimab biosimilar, Whole mAb, Anti-KIT Antibody: Anti-C-Kit/CD117/MASTC/PBT/SCFR therapeutic antibody
    Target AntigenProducts DevelopingMulti-species KIT/ C-Kit/ CD117 VLP (virus-like particle) (Products Developing)
    ORF Viral VectorpGMLV000697house mouse Kit Lentivirus plasmid
    ORF Viral VectorvGMLV000697house mouse Kit Lentivirus particle


    Target information

    Target IDGM-T57700
    Target NameKIT
    Gene ID3815,16590,64030,696759,403811,493766,280832,100009704
    Gene Symbol and SynonymsBs,C-Kit,CD117,Fdc,Gsfsco1,Gsfsco5,Gsfsow3,KIT,MASTC,PBT,SCFR,SCO1,SCO5,SOW3,Ssm,Tr-kit,W
    Uniprot AccessionP10721,O97799,Q28889,P43481
    Uniprot Entry NameKIT_HUMAN,KIT_FELCA,KIT_CANLF,KIT_BOVIN
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target, Immuno-oncology Target, INN Index
    DiseaseNon-Small Cell Lung Cancer
    Gene EnsemblENSG00000157404
    Target ClassificationCheckpoint-Immuno Oncology, Kinase

    The target: KIT, gene name: KIT, also named as C-Kit, CD117, MASTC, PBT, SCFR. This gene encodes a receptor tyrosine kinase. This gene was initially identified as a homolog of the feline sarcoma viral oncogene v-kit and is often referred to as proto-oncogene c-Kit. The canonical form of this glycosylated transmembrane protein has an N-terminal extracellular region with five immunoglobulin-like domains, a transmembrane region, and an intracellular tyrosine kinase domain at the C-terminus. Upon activation by its cytokine ligand, stem cell factor (SCF), this protein phosphorylates multiple intracellular proteins that play a role in in the proliferation, differentiation, migration and apoptosis of many cell types and thereby plays an important role in hematopoiesis, stem cell maintenance, gametogenesis, melanogenesis, and in mast cell development, migration and function. This protein can be a membrane-bound or soluble protein. Mutations in this gene are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous leukemia, and piebaldism. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2020].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.