Anti-CD80/ B7/ B7-1 monoclonal antibody

Anti-CD80/ B7/ B7-1 antibody for FACS & in-vivo assay

Target products collectionGo to CD80/CD80 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)


Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T58238-Ab-1/ GM-Tg-hg-T58238-Ab-2Anti-Human CD80 monoclonal antibodyHuman
GM-Tg-rg-T58238-Ab-1/ GM-Tg-rg-T58238-Ab-2Anti-Rat CD80 monoclonal antibodyRat
GM-Tg-mg-T58238-Ab-1/ GM-Tg-mg-T58238-Ab-2Anti-Mouse CD80 monoclonal antibodyMouse
GM-Tg-cynog-T58238-Ab-1/ GM-Tg-cynog-T58238-Ab-2Anti-Cynomolgus/ Rhesus macaque CD80 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T58238-Ab-1/ GM-Tg-felg-T58238-Ab-2Anti-Feline CD80 monoclonal antibodyFeline
GM-Tg-cang-T58238-Ab-1/ GM-Tg-cang-T58238-Ab-2Anti-Canine CD80 monoclonal antibodyCanine
GM-Tg-bovg-T58238-Ab-1/ GM-Tg-bovg-T58238-Ab-2Anti-Bovine CD80 monoclonal antibodyBovine
GM-Tg-equg-T58238-Ab-1/ GM-Tg-equg-T58238-Ab-2Anti-Equine CD80 monoclonal antibodyEquine

Size: 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T58238-Ab-1/ GM-Tg-hg-T58238-Ab-2; GM-Tg-rg-T58238-Ab-1/ GM-Tg-rg-T58238-Ab-2;
GM-Tg-mg-T58238-Ab-1/ GM-Tg-mg-T58238-Ab-2; GM-Tg-cynog-T58238-Ab-1/ GM-Tg-cynog-T58238-Ab-2;
GM-Tg-felg-T58238-Ab-1/ GM-Tg-felg-T58238-Ab-2; GM-Tg-cang-T58238-Ab-1/ GM-Tg-cang-T58238-Ab-2;
GM-Tg-bovg-T58238-Ab-1/ GM-Tg-bovg-T58238-Ab-2; GM-Tg-equg-T58238-Ab-1/ GM-Tg-equg-T58238-Ab-2
Products NameAnti-CD80 monoclonal antibody
Formatmab
Target NameCD80
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)
IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-CD80 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


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    Associated products


    CategoryCat No.Products Name
    BiosimilarGMP-Bios-INN-753Pre-Made Belatacept Biosimilar, Fusion Protein targeting CD80 fused with human IGHG1 Fc (Fragment constant): Recombinant therapeutic protein targeting B7/B7-1/B7.1/BB1/CD28LG/CD28LG1/LAB7
    BiosimilarGMP-Bios-ab-229Pre-Made Galiximab biosimilar, Whole mAb, Anti-CD80 Antibody: Anti-B7/BB1/B7-1/B7.1/LAB7/CD28LG/CD28LG1 therapeutic antibody
    Target AntigenProducts DevelopingMulti-species CD80/ B7/ B7-1 VLP (virus-like particle) (Products Developing)
    ORF Viral VectorpGMLP000855human CD80 Lentivirus plasmid
    ORF Viral VectorvGMLP000855human CD80 Lentivirus particle


    Target information

    Target IDGM-T58238
    Target NameCD80
    Gene ID941,12519,25408,732518,403765,493786,407131,100071012
    Gene Symbol and SynonymsB7,B7-1,B7.1,B71,BB1,Cd28l,CD28LG,CD28LG1,CD80,LAB7,Ly-53,Ly53,MIC17,TSA1
    Uniprot AccessionP33681
    Uniprot Entry NameCD80_HUMAN
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target, Immuno-oncology Target, INN Index
    DiseaseLipoid nephrosis
    Gene EnsemblENSG00000121594
    Target ClassificationCheckpoint-Immuno Oncology

    The target: CD80, gene name: CD80, also named as B7, B7-1, B7.1, BB1, CD28LG, CD28LG1, LAB7. The protein encoded by this gene is a membrane receptor that is activated by the binding of CD28 or CTLA-4. The activated protein induces T-cell proliferation and cytokine production. This protein can act as a receptor for adenovirus subgroup B and may play a role in lupus neuropathy. [provided by RefSeq, Aug 2011].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.