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Anti-FHIT/ AP3Aase/ FRA3B monoclonal antibody
Anti-FHIT/ AP3Aase/ FRA3B antibody for FACS & in-vivo assay
Go to FHIT/FHIT products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T59720-Ab-1/ GM-Tg-hg-T59720-Ab-2 | Anti-Human FHIT monoclonal antibody | Human |
| GM-Tg-rg-T59720-Ab-1/ GM-Tg-rg-T59720-Ab-2 | Anti-Rat FHIT monoclonal antibody | Rat |
| GM-Tg-mg-T59720-Ab-1/ GM-Tg-mg-T59720-Ab-2 | Anti-Mouse FHIT monoclonal antibody | Mouse |
| GM-Tg-cynog-T59720-Ab-1/ GM-Tg-cynog-T59720-Ab-2 | Anti-Cynomolgus/ Rhesus macaque FHIT monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T59720-Ab-1/ GM-Tg-felg-T59720-Ab-2 | Anti-Feline FHIT monoclonal antibody | Feline |
| GM-Tg-cang-T59720-Ab-1/ GM-Tg-cang-T59720-Ab-2 | Anti-Canine FHIT monoclonal antibody | Canine |
| GM-Tg-bovg-T59720-Ab-1/ GM-Tg-bovg-T59720-Ab-2 | Anti-Bovine FHIT monoclonal antibody | Bovine |
| GM-Tg-equg-T59720-Ab-1/ GM-Tg-equg-T59720-Ab-2 | Anti-Equine FHIT monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T59720-Ab-1/ GM-Tg-hg-T59720-Ab-2; GM-Tg-rg-T59720-Ab-1/ GM-Tg-rg-T59720-Ab-2; GM-Tg-mg-T59720-Ab-1/ GM-Tg-mg-T59720-Ab-2; GM-Tg-cynog-T59720-Ab-1/ GM-Tg-cynog-T59720-Ab-2; GM-Tg-felg-T59720-Ab-1/ GM-Tg-felg-T59720-Ab-2; GM-Tg-cang-T59720-Ab-1/ GM-Tg-cang-T59720-Ab-2; GM-Tg-bovg-T59720-Ab-1/ GM-Tg-bovg-T59720-Ab-2; GM-Tg-equg-T59720-Ab-1/ GM-Tg-equg-T59720-Ab-2 |
| Products Name | Anti-FHIT monoclonal antibody |
| Format | mab |
| Target Name | FHIT |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-FHIT benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species FHIT/ AP3Aase/ FRA3B VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | vGMAP000114 | Human FHIT Adenovirus particle |
| ORF Viral Vector | pGMAP000114 | Human FHIT Adenovirus plasmid |
| ORF Viral Vector | pGMLPm004516 | mouse Fhit Lentivirus plasmid |
| ORF Viral Vector | vGMLPm004516 | mouse Fhit Lentivirus particle |
Target information
| Target ID | GM-T59720 |
| Target Name | FHIT |
| Gene ID | 2272,14198,60398,700974,100215999,101082731,692183,100057165 |
| Gene Symbol and Synonyms | AP3Aase,FHIT,Fra14A2,FRA3B |
| Uniprot Accession | P49789,Q9JIX3,Q1KZG4 |
| Uniprot Entry Name | FHIT_HUMAN,FHIT_RAT,FHIT_BOVIN |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target |
| Disease | Lung Cancer |
| Gene Ensembl | ENSG00000189283 |
| Target Classification | N/A |
The target: FHIT, gene name: FHIT, also named as AP3Aase, FRA3B. The protein encoded by this gene is a P1-P3-bis(5'-adenosyl) triphosphate hydrolase involved in purine metabolism. This gene encompasses the common fragile site FRA3B on chromosome 3, where carcinogen-induced damage can lead to translocations and aberrant transcripts. In fact, aberrant transcripts from this gene have been found in about half of all esophageal, stomach, and colon carcinomas. The encoded protein is also a tumor suppressor, as loss of its activity results in replication stress and DNA damage. [provided by RefSeq, Aug 2017].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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