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Anti-PP1A/ PPP1CA/ PP-1A monoclonal antibody
Anti-PP1A/ PPP1CA/ PP-1A antibody for FACS & in-vivo assay
Go to PPP1CA/PPP1CA products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T59845-Ab-1/ GM-Tg-hg-T59845-Ab-2 | Anti-Human PPP1CA monoclonal antibody | Human |
| GM-Tg-rg-T59845-Ab-1/ GM-Tg-rg-T59845-Ab-2 | Anti-Rat PPP1CA monoclonal antibody | Rat |
| GM-Tg-mg-T59845-Ab-1/ GM-Tg-mg-T59845-Ab-2 | Anti-Mouse PPP1CA monoclonal antibody | Mouse |
| GM-Tg-cynog-T59845-Ab-1/ GM-Tg-cynog-T59845-Ab-2 | Anti-Cynomolgus/ Rhesus macaque PPP1CA monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T59845-Ab-1/ GM-Tg-felg-T59845-Ab-2 | Anti-Feline PPP1CA monoclonal antibody | Feline |
| GM-Tg-cang-T59845-Ab-1/ GM-Tg-cang-T59845-Ab-2 | Anti-Canine PPP1CA monoclonal antibody | Canine |
| GM-Tg-bovg-T59845-Ab-1/ GM-Tg-bovg-T59845-Ab-2 | Anti-Bovine PPP1CA monoclonal antibody | Bovine |
| GM-Tg-equg-T59845-Ab-1/ GM-Tg-equg-T59845-Ab-2 | Anti-Equine PPP1CA monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T59845-Ab-1/ GM-Tg-hg-T59845-Ab-2; GM-Tg-rg-T59845-Ab-1/ GM-Tg-rg-T59845-Ab-2; GM-Tg-mg-T59845-Ab-1/ GM-Tg-mg-T59845-Ab-2; GM-Tg-cynog-T59845-Ab-1/ GM-Tg-cynog-T59845-Ab-2; GM-Tg-felg-T59845-Ab-1/ GM-Tg-felg-T59845-Ab-2; GM-Tg-cang-T59845-Ab-1/ GM-Tg-cang-T59845-Ab-2; GM-Tg-bovg-T59845-Ab-1/ GM-Tg-bovg-T59845-Ab-2; GM-Tg-equg-T59845-Ab-1/ GM-Tg-equg-T59845-Ab-2 |
| Products Name | Anti-PPP1CA monoclonal antibody |
| Format | mab |
| Target Name | PPP1CA |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-PPP1CA benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species PP1A/ PPP1CA/ PP-1A VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | vGMAP000389 | Human PPP1CA Adenovirus particle |
| ORF Viral Vector | vGMLP000473 | human PPP1CA Lentivirus particle |
| ORF Viral Vector | pGMAP000389 | Human PPP1CA Adenovirus plasmid |
| ORF Viral Vector | pGMLP000473 | human PPP1CA Lentivirus plasmid |
| ORF Viral Vector | pGMLPm003925 | mouse Ppp1ca Lentivirus plasmid |
| ORF Viral Vector | vGMLPm003925 | mouse Ppp1ca Lentivirus particle |
Target information
| Target ID | GM-T59845 |
| Target Name | PPP1CA |
| Gene ID | 5499,19045,24668,721735,403609,109492306,516175,100059233 |
| Gene Symbol and Synonyms | dism2,PP-1A,PP1A,PP1alpha,PPP1A,Ppp1c,PPP1CA |
| Uniprot Accession | P62136,P62138,Q8WMS6,Q3T0E7 |
| Uniprot Entry Name | PP1A_HUMAN,PP1A_RAT,PP1A_CANLF,PP1A_BOVIN |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000172531 |
| Target Classification | N/A |
The target: PPP1CA, gene name: PPP1CA, also named as PP-1A, PP1A, PP1alpha, PPP1A. The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). This broadly expressed gene encodes the alpha subunit of the PP1 complex that associates with over 200 regulatory proteins to form holoenzymes which dephosphorylate their biological targets with high specificity. PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Increased PP1 activity has been observed in the end stage of heart failure. Studies suggest that PP1 is an important regulator of cardiac function and that PP1 deregulation is implicated in diabetes and multiple types of cancer. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2020].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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