Anti-RENI/ REN/ HNFJ2 monoclonal antibody
Anti-RENI/ REN/ HNFJ2 antibody for FACS & in-vivo assay
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(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
Product information
Catalog No. | Product Name | Species Reactivity |
---|---|---|
GM-Tg-hg-T61622-Ab-1/ GM-Tg-hg-T61622-Ab-2 | Anti-Human REN monoclonal antibody | Human |
GM-Tg-rg-T61622-Ab-1/ GM-Tg-rg-T61622-Ab-2 | Anti-Rat REN monoclonal antibody | Rat |
GM-Tg-mg-T61622-Ab-1/ GM-Tg-mg-T61622-Ab-2 | Anti-Mouse REN monoclonal antibody | Mouse |
GM-Tg-cynog-T61622-Ab-1/ GM-Tg-cynog-T61622-Ab-2 | Anti-Cynomolgus/ Rhesus macaque REN monoclonal antibody | Cynomolgus/ Rhesus macaque |
GM-Tg-felg-T61622-Ab-1/ GM-Tg-felg-T61622-Ab-2 | Anti-Feline REN monoclonal antibody | Feline |
GM-Tg-cang-T61622-Ab-1/ GM-Tg-cang-T61622-Ab-2 | Anti-Canine REN monoclonal antibody | Canine |
GM-Tg-bovg-T61622-Ab-1/ GM-Tg-bovg-T61622-Ab-2 | Anti-Bovine REN monoclonal antibody | Bovine |
GM-Tg-equg-T61622-Ab-1/ GM-Tg-equg-T61622-Ab-2 | Anti-Equine REN monoclonal antibody | Equine |
Size: 1mg | 10mg | 100mg
Product Description
Catalog No. | GM-Tg-hg-T61622-Ab-1/ GM-Tg-hg-T61622-Ab-2; GM-Tg-rg-T61622-Ab-1/ GM-Tg-rg-T61622-Ab-2; GM-Tg-mg-T61622-Ab-1/ GM-Tg-mg-T61622-Ab-2; GM-Tg-cynog-T61622-Ab-1/ GM-Tg-cynog-T61622-Ab-2; GM-Tg-felg-T61622-Ab-1/ GM-Tg-felg-T61622-Ab-2; GM-Tg-cang-T61622-Ab-1/ GM-Tg-cang-T61622-Ab-2; GM-Tg-bovg-T61622-Ab-1/ GM-Tg-bovg-T61622-Ab-2; GM-Tg-equg-T61622-Ab-1/ GM-Tg-equg-T61622-Ab-2 |
Products Name | Anti-REN monoclonal antibody |
Format | mab |
Target Name | REN |
Protein Sub-location | Transmembrane Protein |
Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
Derivation (species) | Mouse |
CH1+2+3 Isotype (Receptor identification) | IgG |
Type of Light Chain (VD-LC) | N/A |
Expression platform | Mammalian Expression |
Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
Tag | Fc |
Products description | Pre-made anti-REN benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
Purity | Purity: ≥95% (SDS-PAGE) |
Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
Category | Cat No. | Products Name |
Target Antigen | Products Developing | Multi-species RENI/ REN/ HNFJ2 VLP (virus-like particle) (Products Developing) |
ORF Viral Vector | pGMLP000714 | human REN Lentivirus plasmid |
ORF Viral Vector | vGMLP000714 | human REN Lentivirus particle |
ORF Viral Vector | pGMLPm004976 | mouse Ren1 Lentivirus plasmid |
ORF Viral Vector | vGMLPm004976 | mouse Ren1 Lentivirus particle |
Target information
Target ID | GM-T61622 |
Target Name | REN |
Gene ID | 5972,19701,24715,574299,403838,101081695,280909,100054248 |
Gene Symbol and Synonyms | ADTKD4,HNFJ2,RATRENAA,REN,Ren-1,Ren-A,Ren1,Ren1c,Ren1d,RENAA,Rn-1,Rnr,RTD |
Uniprot Accession | P00797,P08424,Q6DLW5,Q6DYE7 |
Uniprot Entry Name | RENI_HUMAN,RENI_MACMU,RENI_RAT,RENI_CANLF |
Protein Sub-location | Transmembrane Protein |
Category | Therapeutics Target |
Disease | Lung Cancer, Sepsis |
Gene Ensembl | ENSG00000143839 |
Target Classification | N/A |
The target: REN, gene name: REN, also named as HNFJ2. This gene encodes renin, an aspartic protease that is secreted by the kidneys. Renin is a part of the renin-angiotensin-aldosterone system involved in regulation of blood pressure, and electrolyte balance. This enzyme catalyzes the first step in the activation pathway of angiotensinogen by cleaving angiotensinogen to form angiotensin I, which is then converted to angiotensin II by angiotensin I converting enzyme. This cascade can result in aldosterone release, narrowing of blood vessels, and increase in blood pressure as angiotension II is a vasoconstrictive peptide. Transcript variants that encode different protein isoforms and that arise from alternative splicing and the use of alternative promoters have been described, but their full-length nature has not been determined. Mutations in this gene have been shown to cause hyperuricemic nephropathy familial juvenile 2, familial hyperproreninemia, and renal tubular dysgenesis. [provided by RefSeq, May 2020].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.