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Anti-RARB monoclonal antibody
Pre-made anti-RARB monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to RARB/RARB products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T61657-Ab-1/ GM-Tg-hg-T61657-Ab-2 | Anti-Human RARB monoclonal antibody | Human |
| GM-Tg-rg-T61657-Ab-1/ GM-Tg-rg-T61657-Ab-2 | Anti-Rat RARB monoclonal antibody | Rat |
| GM-Tg-mg-T61657-Ab-1/ GM-Tg-mg-T61657-Ab-2 | Anti-Mouse RARB monoclonal antibody | Mouse |
| GM-Tg-cynog-T61657-Ab-1/ GM-Tg-cynog-T61657-Ab-2 | Anti-Cynomolgus/ Rhesus macaque RARB monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T61657-Ab-1/ GM-Tg-felg-T61657-Ab-2 | Anti-Feline RARB monoclonal antibody | Feline |
| GM-Tg-cang-T61657-Ab-1/ GM-Tg-cang-T61657-Ab-2 | Anti-Canine RARB monoclonal antibody | Canine |
| GM-Tg-bovg-T61657-Ab-1/ GM-Tg-bovg-T61657-Ab-2 | Anti-Bovine RARB monoclonal antibody | Bovine |
| GM-Tg-equg-T61657-Ab-1/ GM-Tg-equg-T61657-Ab-2 | Anti-Equine RARB monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T61657-Ab-1/ GM-Tg-hg-T61657-Ab-2; GM-Tg-rg-T61657-Ab-1/ GM-Tg-rg-T61657-Ab-2; GM-Tg-mg-T61657-Ab-1/ GM-Tg-mg-T61657-Ab-2; GM-Tg-cynog-T61657-Ab-1/ GM-Tg-cynog-T61657-Ab-2; GM-Tg-felg-T61657-Ab-1/ GM-Tg-felg-T61657-Ab-2; GM-Tg-cang-T61657-Ab-1/ GM-Tg-cang-T61657-Ab-2; GM-Tg-bovg-T61657-Ab-1/ GM-Tg-bovg-T61657-Ab-2; GM-Tg-equg-T61657-Ab-1/ GM-Tg-equg-T61657-Ab-2 |
| Products Name | Anti-RARB monoclonal antibody |
| Format | mab |
| Target Name | RARB |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-RARB monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T61657-Ag-1 | Recombinant multi-species RARB/ HAP/ MCOPS12 protein |
| ORF Viral Vector | pGMLP000710 | human RARB Lentivirus plasmid |
| ORF Viral Vector | vGMLP000710 | human RARB Lentivirus particle |
| ORF Viral Vector | pGMLPm004886 | mouse Rarb Lentivirus plasmid |
| ORF Viral Vector | vGMLPm004886 | mouse Rarb Lentivirus particle |
Target information
| Target ID | GM-T61657 |
| Target Name | RARB |
| Gene ID | 5915,218772,24706,700485,477045,101085742,616895,100051546 |
| Gene Symbol and Synonyms | A830025K23,HAP,MCOPS12,NR1B2,RARB,RARbeta,RARbeta1,RRB2 |
| Uniprot Accession | P10826 |
| Uniprot Entry Name | RARB_HUMAN |
| Protein Sub-location | Introcelluar Protein |
| Category | Therapeutics Target |
| Disease | Lung Cancer |
| Gene Ensembl | ENSG00000077092 |
| Target Classification | N/A |
The target: RARB, gene name: RARB, also named as HAP, MCOPS12, NR1B2, RARbeta1, RRB2. This gene encodes retinoic acid receptor beta, a member of the thyroid-steroid hormone receptor superfamily of nuclear transcriptional regulators. This receptor localizes to the cytoplasm and to subnuclear compartments. It binds retinoic acid, the biologically active form of vitamin A which mediates cellular signalling in embryonic morphogenesis, cell growth and differentiation. It is thought that this protein limits growth of many cell types by regulating gene expression. The gene was first identified in a hepatocellular carcinoma where it flanks a hepatitis B virus integration site. Alternate promoter usage and differential splicing result in multiple transcript variants. [provided by RefSeq, Mar 2014].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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