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Anti-IL2/ IL-2/ TCGF functional antibody
Anti-IL2/ IL-2/ TCGF functional antibody for cell culture, ELISA & in-vivo assay
Go to IL2/IL2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T61698-Ab-1/ GM-Tg-hg-T61698-Ab-2 | Anti-Human IL2 monoclonal antibody | Human |
| GM-Tg-rg-T61698-Ab-1/ GM-Tg-rg-T61698-Ab-2 | Anti-Rat IL2 monoclonal antibody | Rat |
| GM-Tg-mg-T61698-Ab-1/ GM-Tg-mg-T61698-Ab-2 | Anti-Mouse IL2 monoclonal antibody | Mouse |
| GM-Tg-cynog-T61698-Ab-1/ GM-Tg-cynog-T61698-Ab-2 | Anti-Cynomolgus/ Rhesus macaque IL2 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T61698-Ab-1/ GM-Tg-felg-T61698-Ab-2 | Anti-Feline IL2 monoclonal antibody | Feline |
| GM-Tg-cang-T61698-Ab-1/ GM-Tg-cang-T61698-Ab-2 | Anti-Canine IL2 monoclonal antibody | Canine |
| GM-Tg-bovg-T61698-Ab-1/ GM-Tg-bovg-T61698-Ab-2 | Anti-Bovine IL2 monoclonal antibody | Bovine |
| GM-Tg-equg-T61698-Ab-1/ GM-Tg-equg-T61698-Ab-2 | Anti-Equine IL2 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T61698-Ab-1/ GM-Tg-hg-T61698-Ab-2; GM-Tg-rg-T61698-Ab-1/ GM-Tg-rg-T61698-Ab-2; GM-Tg-mg-T61698-Ab-1/ GM-Tg-mg-T61698-Ab-2; GM-Tg-cynog-T61698-Ab-1/ GM-Tg-cynog-T61698-Ab-2; GM-Tg-felg-T61698-Ab-1/ GM-Tg-felg-T61698-Ab-2; GM-Tg-cang-T61698-Ab-1/ GM-Tg-cang-T61698-Ab-2; GM-Tg-bovg-T61698-Ab-1/ GM-Tg-bovg-T61698-Ab-2; GM-Tg-equg-T61698-Ab-1/ GM-Tg-equg-T61698-Ab-2 |
| Products Name | Anti-IL2 monoclonal antibody |
| Format | mab |
| Target Name | IL2 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-IL2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Biosimilar | GMP-Bios-INN-811 | Pre-Made Efavaleukin Alfa Biosimilar, Fusion Protein targeting IL2 fused with human IGHG1 Fc (Fragment constant): Recombinant therapeutic protein targeting IL-2/TCGF/lymphokine |
| Target Antigen | GM-Tg-g-T61698-Ag-1 | Recombinant multi-species IL2/ IL-2/ TCGF protein |
| ORF Viral Vector | pGMAP000406 | Human IL2 Adenovirus plasmid |
| ORF Viral Vector | vGMLP000542 | human IL2 Lentivirus particle |
| ORF Viral Vector | vGMAP000406 | Human IL2 Adenovirus particle |
| ORF Viral Vector | pGMLP000542 | human IL2 Lentivirus plasmid |
| ORF Viral Vector | pGMAAV000371 | house mouse Il2 AAV plasmid |
| ORF Viral Vector | vGMAAV000371 | house mouse Il2 AAV particle |
Target information
| Target ID | GM-T61698 |
| Target Name | IL2 |
| Gene ID | 3558,16183,116562,708017,403989,751114,280822,100034204 |
| Gene Symbol and Synonyms | IL-2,IL2,lymphokine,TCGF |
| Uniprot Accession | P60568,P17108,P68291,Q29416,Q07885,P05016,P37997 |
| Uniprot Entry Name | IL2_HUMAN,IL2_MACMU,IL2_RAT,IL2_FELCA,IL2_CANLF,IL2_BOVIN,IL2_HORSE |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | Therapeutics Target, Immuno-oncology Target, INN Index |
| Disease | Chronic Kidney Disease |
| Gene Ensembl | ENSG00000109471 |
| Target Classification | Checkpoint-Immuno Oncology |
The target: IL2, gene name: IL2, also named as IL-2, TCGF, lymphokine. This gene is a member of the interleukin 2 (IL2) cytokine subfamily which includes IL4, IL7, IL9, IL15, IL21, erythropoietin, and thrombopoietin. The protein encoded by this gene is a secreted cytokine produced by activated CD4+ and CD8+ T lymphocytes, that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine (IL2R) is a heterotrimeric protein complex whose gamma chain is also shared by IL4 and IL7. The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli. [provided by RefSeq, Sep 2020].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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