Anti-SC6A1/ SLC6A1/ GABATHG monoclonal antibody
Anti-SC6A1/ SLC6A1/ GABATHG antibody for FACS & in-vivo assay
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(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
Product information
Catalog No. | Product Name | Species Reactivity |
---|---|---|
GM-Tg-hg-T62184-Ab-1/ GM-Tg-hg-T62184-Ab-2 | Anti-Human SLC6A1 monoclonal antibody | Human |
GM-Tg-rg-T62184-Ab-1/ GM-Tg-rg-T62184-Ab-2 | Anti-Rat SLC6A1 monoclonal antibody | Rat |
GM-Tg-mg-T62184-Ab-1/ GM-Tg-mg-T62184-Ab-2 | Anti-Mouse SLC6A1 monoclonal antibody | Mouse |
GM-Tg-cynog-T62184-Ab-1/ GM-Tg-cynog-T62184-Ab-2 | Anti-Cynomolgus/ Rhesus macaque SLC6A1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
GM-Tg-felg-T62184-Ab-1/ GM-Tg-felg-T62184-Ab-2 | Anti-Feline SLC6A1 monoclonal antibody | Feline |
GM-Tg-cang-T62184-Ab-1/ GM-Tg-cang-T62184-Ab-2 | Anti-Canine SLC6A1 monoclonal antibody | Canine |
GM-Tg-bovg-T62184-Ab-1/ GM-Tg-bovg-T62184-Ab-2 | Anti-Bovine SLC6A1 monoclonal antibody | Bovine |
GM-Tg-equg-T62184-Ab-1/ GM-Tg-equg-T62184-Ab-2 | Anti-Equine SLC6A1 monoclonal antibody | Equine |
Size: 1mg | 10mg | 100mg
Product Description
Catalog No. | GM-Tg-hg-T62184-Ab-1/ GM-Tg-hg-T62184-Ab-2; GM-Tg-rg-T62184-Ab-1/ GM-Tg-rg-T62184-Ab-2; GM-Tg-mg-T62184-Ab-1/ GM-Tg-mg-T62184-Ab-2; GM-Tg-cynog-T62184-Ab-1/ GM-Tg-cynog-T62184-Ab-2; GM-Tg-felg-T62184-Ab-1/ GM-Tg-felg-T62184-Ab-2; GM-Tg-cang-T62184-Ab-1/ GM-Tg-cang-T62184-Ab-2; GM-Tg-bovg-T62184-Ab-1/ GM-Tg-bovg-T62184-Ab-2; GM-Tg-equg-T62184-Ab-1/ GM-Tg-equg-T62184-Ab-2 |
Products Name | Anti-SLC6A1 monoclonal antibody |
Format | mab |
Target Name | SLC6A1 |
Protein Sub-location | Transmembrane Protein |
Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
Derivation (species) | Mouse |
CH1+2+3 Isotype (Receptor identification) | IgG |
Type of Light Chain (VD-LC) | N/A |
Expression platform | Mammalian Expression |
Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
Tag | Fc |
Products description | Pre-made anti-SLC6A1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
Purity | Purity: ≥95% (SDS-PAGE) |
Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
Category | Cat No. | Products Name |
Target Antigen | Products Developing | Multi-species SC6A1/ SLC6A1/ GABATHG VLP (virus-like particle) (Products Developing) |
ORF Viral Vector | vGMLP004008 | human SLC6A1 Lentivirus particle |
ORF Viral Vector | pGMLP004008 | human SLC6A1 Lentivirus plasmid |
ORF Viral Vector | pGMLPm004347 | mouse Slc6a1 Lentivirus plasmid |
ORF Viral Vector | vGMLPm004347 | mouse Slc6a1 Lentivirus particle |
Target information
Target ID | GM-T62184 |
Target Name | SLC6A1 |
Gene ID | 6529,232333,79212,696617,484655,101088066,407118,100051613 |
Gene Symbol and Synonyms | A730043E01,GABATHG,GABATR,Gabt,Gabt1,GAT-1,GAT1,hGAT-1,MAE,SLC6A1,XT-1,Xtrp1 |
Uniprot Accession | P30531,P23978 |
Uniprot Entry Name | SC6A1_HUMAN,SC6A1_RAT |
Protein Sub-location | Transmembrane Protein |
Category | Therapeutics Target |
Disease | N/A |
Gene Ensembl | ENSG00000157103 |
Target Classification | N/A |
The target: SLC6A1, gene name: SLC6A1, also named as GABATHG, GABATR, GAT1, MAE. The protein encoded by this gene is a gamma-aminobutyric acid (GABA) transporter that localizes to the plasma membrane. The encoded protein removes GABA from the synaptic cleft, restoring it to presynaptic terminals. [provided by RefSeq, Jan 2017].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.