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Anti-DDC monoclonal antibody
Pre-made anti-DDC monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to DDC/DDC products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T62193-Ab-1/ GM-Tg-hg-T62193-Ab-2 | Anti-Human DDC monoclonal antibody | Human |
| GM-Tg-rg-T62193-Ab-1/ GM-Tg-rg-T62193-Ab-2 | Anti-Rat DDC monoclonal antibody | Rat |
| GM-Tg-mg-T62193-Ab-1/ GM-Tg-mg-T62193-Ab-2 | Anti-Mouse DDC monoclonal antibody | Mouse |
| GM-Tg-cynog-T62193-Ab-1/ GM-Tg-cynog-T62193-Ab-2 | Anti-Cynomolgus/ Rhesus macaque DDC monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T62193-Ab-1/ GM-Tg-felg-T62193-Ab-2 | Anti-Feline DDC monoclonal antibody | Feline |
| GM-Tg-cang-T62193-Ab-1/ GM-Tg-cang-T62193-Ab-2 | Anti-Canine DDC monoclonal antibody | Canine |
| GM-Tg-bovg-T62193-Ab-1/ GM-Tg-bovg-T62193-Ab-2 | Anti-Bovine DDC monoclonal antibody | Bovine |
| GM-Tg-equg-T62193-Ab-1/ GM-Tg-equg-T62193-Ab-2 | Anti-Equine DDC monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T62193-Ab-1/ GM-Tg-hg-T62193-Ab-2; GM-Tg-rg-T62193-Ab-1/ GM-Tg-rg-T62193-Ab-2; GM-Tg-mg-T62193-Ab-1/ GM-Tg-mg-T62193-Ab-2; GM-Tg-cynog-T62193-Ab-1/ GM-Tg-cynog-T62193-Ab-2; GM-Tg-felg-T62193-Ab-1/ GM-Tg-felg-T62193-Ab-2; GM-Tg-cang-T62193-Ab-1/ GM-Tg-cang-T62193-Ab-2; GM-Tg-bovg-T62193-Ab-1/ GM-Tg-bovg-T62193-Ab-2; GM-Tg-equg-T62193-Ab-1/ GM-Tg-equg-T62193-Ab-2 |
| Products Name | Anti-DDC monoclonal antibody |
| Format | mab |
| Target Name | DDC |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-DDC monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T62193-Ag-1 | Recombinant multi-species DDC/ AADC protein |
| ORF Viral Vector | pGMLPm001636 | mouse Ddc Lentivirus plasmid |
| ORF Viral Vector | vGMLPm001636 | mouse Ddc Lentivirus particle |
Target information
| Target ID | GM-T62193 |
| Target Name | DDC |
| Gene ID | 1644,13195,24311,693677,606852,101082989,280762,100052557 |
| Gene Symbol and Synonyms | AADC,DDC |
| Uniprot Accession | P20711,P14173,P27718 |
| Uniprot Entry Name | DDC_HUMAN,DDC_RAT,DDC_BOVIN |
| Protein Sub-location | Introcelluar Protein |
| Category | Therapeutics Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000132437 |
| Target Classification | N/A |
The target: DDC, gene name: DDC, also named as AADC. The encoded protein catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine. Defects in this gene are the cause of aromatic L-amino-acid decarboxylase deficiency (AADCD). AADCD deficiency is an inborn error in neurotransmitter metabolism that leads to combined serotonin and catecholamine deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jun 2011].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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