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Anti-NMDZ1/ NMDAR1/ GRIN1 monoclonal antibody
Anti-NMDZ1/ NMDAR1/ GRIN1 antibody for FACS & in-vivo assay
Go to NMDAR1/GRIN1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T62276-Ab-1/ GM-Tg-hg-T62276-Ab-2 | Anti-Human NMDAR1/GRIN1 monoclonal antibody | Human |
| GM-Tg-rg-T62276-Ab-1/ GM-Tg-rg-T62276-Ab-2 | Anti-Rat NMDAR1/GRIN1 monoclonal antibody | Rat |
| GM-Tg-mg-T62276-Ab-1/ GM-Tg-mg-T62276-Ab-2 | Anti-Mouse NMDAR1/GRIN1 monoclonal antibody | Mouse |
| GM-Tg-cynog-T62276-Ab-1/ GM-Tg-cynog-T62276-Ab-2 | Anti-Cynomolgus/ Rhesus macaque NMDAR1/GRIN1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T62276-Ab-1/ GM-Tg-felg-T62276-Ab-2 | Anti-Feline NMDAR1/GRIN1 monoclonal antibody | Feline |
| GM-Tg-cang-T62276-Ab-1/ GM-Tg-cang-T62276-Ab-2 | Anti-Canine NMDAR1/GRIN1 monoclonal antibody | Canine |
| GM-Tg-bovg-T62276-Ab-1/ GM-Tg-bovg-T62276-Ab-2 | Anti-Bovine NMDAR1/GRIN1 monoclonal antibody | Bovine |
| GM-Tg-equg-T62276-Ab-1/ GM-Tg-equg-T62276-Ab-2 | Anti-Equine NMDAR1/GRIN1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T62276-Ab-1/ GM-Tg-hg-T62276-Ab-2; GM-Tg-rg-T62276-Ab-1/ GM-Tg-rg-T62276-Ab-2; GM-Tg-mg-T62276-Ab-1/ GM-Tg-mg-T62276-Ab-2; GM-Tg-cynog-T62276-Ab-1/ GM-Tg-cynog-T62276-Ab-2; GM-Tg-felg-T62276-Ab-1/ GM-Tg-felg-T62276-Ab-2; GM-Tg-cang-T62276-Ab-1/ GM-Tg-cang-T62276-Ab-2; GM-Tg-bovg-T62276-Ab-1/ GM-Tg-bovg-T62276-Ab-2; GM-Tg-equg-T62276-Ab-1/ GM-Tg-equg-T62276-Ab-2 |
| Products Name | Anti-NMDAR1/GRIN1 monoclonal antibody |
| Format | mab |
| Target Name | NMDAR1 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-NMDAR1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species NMDZ1/ NMDAR1/ GRIN1 VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | pGMAD000208 | mouse Grin1 Adenovirus plasmid |
| ORF Viral Vector | vGMAD000208 | mouse Grin1 Adenovirus particle |
Target information
| Target ID | GM-T62276 |
| Target Name | NMDAR1 |
| Gene ID | 2902,14810,24408,574380,494007,101082021,100336579,100059861 |
| Gene Symbol and Synonyms | DEE101,GluN1,GluRdelta1,GluRzeta1,GRIN1,M100174,MRD8,NDHMSD,NDHMSR,NMD-R1,NMDA1,Nmdar,NMDAR1,NR1,Rgsc174 |
| Uniprot Accession | Q05586,P35439,Q5R1P0 |
| Uniprot Entry Name | NMDZ1_HUMAN,NMDZ1_RAT,NMDZ1_CANLF |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000176884 |
| Target Classification | N/A |
The target: NMDAR1, gene name: GRIN1, also named as GluN1, MRD8, NDHMSD, NDHMSR, NMD-R1, NMDA1, NMDAR1, NR1. The protein encoded by this gene is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. These subunits play a key role in the plasticity of synapses, which is believed to underlie memory and learning. Cell-specific factors are thought to control expression of different isoforms, possibly contributing to the functional diversity of the subunits. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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