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Anti-TH monoclonal antibody
Pre-made anti-TH monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to TH/TH products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T62390-Ab-1/ GM-Tg-hg-T62390-Ab-2 | Anti-Human TH monoclonal antibody | Human |
| GM-Tg-rg-T62390-Ab-1/ GM-Tg-rg-T62390-Ab-2 | Anti-Rat TH monoclonal antibody | Rat |
| GM-Tg-mg-T62390-Ab-1/ GM-Tg-mg-T62390-Ab-2 | Anti-Mouse TH monoclonal antibody | Mouse |
| GM-Tg-cynog-T62390-Ab-1/ GM-Tg-cynog-T62390-Ab-2 | Anti-Cynomolgus/ Rhesus macaque TH monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T62390-Ab-1/ GM-Tg-felg-T62390-Ab-2 | Anti-Feline TH monoclonal antibody | Feline |
| GM-Tg-cang-T62390-Ab-1/ GM-Tg-cang-T62390-Ab-2 | Anti-Canine TH monoclonal antibody | Canine |
| GM-Tg-bovg-T62390-Ab-1/ GM-Tg-bovg-T62390-Ab-2 | Anti-Bovine TH monoclonal antibody | Bovine |
| GM-Tg-equg-T62390-Ab-1/ GM-Tg-equg-T62390-Ab-2 | Anti-Equine TH monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T62390-Ab-1/ GM-Tg-hg-T62390-Ab-2; GM-Tg-rg-T62390-Ab-1/ GM-Tg-rg-T62390-Ab-2; GM-Tg-mg-T62390-Ab-1/ GM-Tg-mg-T62390-Ab-2; GM-Tg-cynog-T62390-Ab-1/ GM-Tg-cynog-T62390-Ab-2; GM-Tg-felg-T62390-Ab-1/ GM-Tg-felg-T62390-Ab-2; GM-Tg-cang-T62390-Ab-1/ GM-Tg-cang-T62390-Ab-2; GM-Tg-bovg-T62390-Ab-1/ GM-Tg-bovg-T62390-Ab-2; GM-Tg-equg-T62390-Ab-1/ GM-Tg-equg-T62390-Ab-2 |
| Products Name | Anti-TH monoclonal antibody |
| Format | mab |
| Target Name | TH |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-TH monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T62390-Ag-1 | Recombinant multi-species TY3H/ TH/ DYT14 protein |
| ORF Viral Vector | pGMLPm002973 | mouse Th Lentivirus plasmid |
| ORF Viral Vector | vGMLPm002973 | mouse Th Lentivirus particle |
Target information
| Target ID | GM-T62390 |
| Target Name | TH |
| Gene ID | 7054,21823,25085,721137,403444,101090720,280707,100146648 |
| Gene Symbol and Synonyms | DYT14,DYT5b,TH,The,TYH |
| Uniprot Accession | P07101,P04177,Q76IQ3,P17289 |
| Uniprot Entry Name | TY3H_HUMAN,TY3H_RAT,TY3H_CANLF,TY3H_BOVIN |
| Protein Sub-location | Introcelluar Protein |
| Category | Therapeutics Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000180176 |
| Target Classification | N/A |
The target: TH, gene name: TH, also named as DYT14, DYT5b, TYH. The protein encoded by this gene is involved in the conversion of tyrosine to dopamine. It is the rate-limiting enzyme in the synthesis of catecholamines, hence plays a key role in the physiology of adrenergic neurons. Mutations in this gene have been associated with autosomal recessive Segawa syndrome. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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