Anti-KSYK/ SYK/ p72-Syk monoclonal antibody

Anti-KSYK/ SYK/ p72-Syk antibody for FACS & in-vivo assay

Target products collectionGo to SYK/SYK products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)


Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T62431-Ab-1/ GM-Tg-hg-T62431-Ab-2Anti-Human SYK monoclonal antibodyHuman
GM-Tg-rg-T62431-Ab-1/ GM-Tg-rg-T62431-Ab-2Anti-Rat SYK monoclonal antibodyRat
GM-Tg-mg-T62431-Ab-1/ GM-Tg-mg-T62431-Ab-2Anti-Mouse SYK monoclonal antibodyMouse
GM-Tg-cynog-T62431-Ab-1/ GM-Tg-cynog-T62431-Ab-2Anti-Cynomolgus/ Rhesus macaque SYK monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T62431-Ab-1/ GM-Tg-felg-T62431-Ab-2Anti-Feline SYK monoclonal antibodyFeline
GM-Tg-cang-T62431-Ab-1/ GM-Tg-cang-T62431-Ab-2Anti-Canine SYK monoclonal antibodyCanine
GM-Tg-bovg-T62431-Ab-1/ GM-Tg-bovg-T62431-Ab-2Anti-Bovine SYK monoclonal antibodyBovine
GM-Tg-equg-T62431-Ab-1/ GM-Tg-equg-T62431-Ab-2Anti-Equine SYK monoclonal antibodyEquine

Size: 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T62431-Ab-1/ GM-Tg-hg-T62431-Ab-2; GM-Tg-rg-T62431-Ab-1/ GM-Tg-rg-T62431-Ab-2;
GM-Tg-mg-T62431-Ab-1/ GM-Tg-mg-T62431-Ab-2; GM-Tg-cynog-T62431-Ab-1/ GM-Tg-cynog-T62431-Ab-2;
GM-Tg-felg-T62431-Ab-1/ GM-Tg-felg-T62431-Ab-2; GM-Tg-cang-T62431-Ab-1/ GM-Tg-cang-T62431-Ab-2;
GM-Tg-bovg-T62431-Ab-1/ GM-Tg-bovg-T62431-Ab-2; GM-Tg-equg-T62431-Ab-1/ GM-Tg-equg-T62431-Ab-2
Products NameAnti-SYK monoclonal antibody
Formatmab
Target NameSYK
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)
IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-SYK benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species KSYK/ SYK/ p72-Syk VLP (virus-like particle) (Products Developing)
    ORF Viral VectorpGMLP001433human SYK Lentivirus plasmid
    ORF Viral VectorvGMLP001433human SYK Lentivirus particle
    ORF Viral VectorpGMAP000142Human SYK Adenovirus plasmid
    ORF Viral VectorvGMAP000142Human SYK Adenovirus particle


    Target information

    Target IDGM-T62431
    Target NameSYK
    Gene ID6850,20963,25155,704102,484196,101087013,515515,100063383
    Gene Symbol and SynonymsIMD82,p72-Syk,p72syk,SYK,Sykb
    Uniprot AccessionP43405,Q64725
    Uniprot Entry NameKSYK_HUMAN,KSYK_RAT
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target
    DiseaseCancer
    Gene EnsemblENSG00000165025
    Target ClassificationKinase, Tumor-associated antigen (TAA)

    The target: SYK, gene name: SYK, also named as p72-Syk. This gene encodes a member of the family of non-receptor type Tyr protein kinases. This protein is widely expressed in hematopoietic cells and is involved in coupling activated immunoreceptors to downstream signaling events that mediate diverse cellular responses, including proliferation, differentiation, and phagocytosis. It is thought to be a modulator of epithelial cell growth and a potential tumour suppressor in human breast carcinomas. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.