Anti-ADCY1/ AC1/ DFNB44 monoclonal antibody

Anti-ADCY1/ AC1/ DFNB44 antibody for FACS & in-vivo assay

Target products collectionGo to ADCY1/ADCY1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T63609-Ab-1/ GM-Tg-hg-T63609-Ab-2Anti-Human ADCY1 monoclonal antibodyHuman
GM-Tg-rg-T63609-Ab-1/ GM-Tg-rg-T63609-Ab-2Anti-Rat ADCY1 monoclonal antibodyRat
GM-Tg-mg-T63609-Ab-1/ GM-Tg-mg-T63609-Ab-2Anti-Mouse ADCY1 monoclonal antibodyMouse
GM-Tg-cynog-T63609-Ab-1/ GM-Tg-cynog-T63609-Ab-2Anti-Cynomolgus/ Rhesus macaque ADCY1 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T63609-Ab-1/ GM-Tg-felg-T63609-Ab-2Anti-Feline ADCY1 monoclonal antibodyFeline
GM-Tg-cang-T63609-Ab-1/ GM-Tg-cang-T63609-Ab-2Anti-Canine ADCY1 monoclonal antibodyCanine
GM-Tg-bovg-T63609-Ab-1/ GM-Tg-bovg-T63609-Ab-2Anti-Bovine ADCY1 monoclonal antibodyBovine
GM-Tg-equg-T63609-Ab-1/ GM-Tg-equg-T63609-Ab-2Anti-Equine ADCY1 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T63609-Ab-1/ GM-Tg-hg-T63609-Ab-2; GM-Tg-rg-T63609-Ab-1/ GM-Tg-rg-T63609-Ab-2;
GM-Tg-mg-T63609-Ab-1/ GM-Tg-mg-T63609-Ab-2; GM-Tg-cynog-T63609-Ab-1/ GM-Tg-cynog-T63609-Ab-2;
GM-Tg-felg-T63609-Ab-1/ GM-Tg-felg-T63609-Ab-2; GM-Tg-cang-T63609-Ab-1/ GM-Tg-cang-T63609-Ab-2;
GM-Tg-bovg-T63609-Ab-1/ GM-Tg-bovg-T63609-Ab-2; GM-Tg-equg-T63609-Ab-1/ GM-Tg-equg-T63609-Ab-2
Products NameAnti-ADCY1 monoclonal antibody
Formatmab
Target NameADCY1
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-ADCY1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species ADCY1/ AC1/ DFNB44 VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-T63609
    Target NameADCY1
    Gene ID107,432530,305509,697230,101101375,281601,100065563
    Gene Symbol and SynonymsAC1,ADCY1,brl,D11Bwg1392e,DFNB44,I-AC
    Uniprot AccessionQ08828,P19754
    Uniprot Entry NameADCY1_HUMAN,ADCY1_BOVIN
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target
    DiseaseNervous system function
    Gene EnsemblENSG00000164742
    Target ClassificationN/A

    The target: ADCY1, gene name: ADCY1, also named as AC1, DFNB44. This gene encodes a member of the of adenylate cyclase gene family that is primarily expressed in the brain. This protein is regulated by calcium/calmodulin concentration and may be involved in brain development. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.