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Anti-CP46A/ CYP46A1/ CP46 functional antibody
Anti-CP46A/ CYP46A1/ CP46 functional antibody for cell culture, ELISA & in-vivo assay
Go to CYP46A1/CYP46A1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T64242-Ab-1/ GM-Tg-hg-T64242-Ab-2 | Anti-Human CYP46A1 monoclonal antibody | Human |
| GM-Tg-rg-T64242-Ab-1/ GM-Tg-rg-T64242-Ab-2 | Anti-Rat CYP46A1 monoclonal antibody | Rat |
| GM-Tg-mg-T64242-Ab-1/ GM-Tg-mg-T64242-Ab-2 | Anti-Mouse CYP46A1 monoclonal antibody | Mouse |
| GM-Tg-cynog-T64242-Ab-1/ GM-Tg-cynog-T64242-Ab-2 | Anti-Cynomolgus/ Rhesus macaque CYP46A1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T64242-Ab-1/ GM-Tg-felg-T64242-Ab-2 | Anti-Feline CYP46A1 monoclonal antibody | Feline |
| GM-Tg-cang-T64242-Ab-1/ GM-Tg-cang-T64242-Ab-2 | Anti-Canine CYP46A1 monoclonal antibody | Canine |
| GM-Tg-bovg-T64242-Ab-1/ GM-Tg-bovg-T64242-Ab-2 | Anti-Bovine CYP46A1 monoclonal antibody | Bovine |
| GM-Tg-equg-T64242-Ab-1/ GM-Tg-equg-T64242-Ab-2 | Anti-Equine CYP46A1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T64242-Ab-1/ GM-Tg-hg-T64242-Ab-2; GM-Tg-rg-T64242-Ab-1/ GM-Tg-rg-T64242-Ab-2; GM-Tg-mg-T64242-Ab-1/ GM-Tg-mg-T64242-Ab-2; GM-Tg-cynog-T64242-Ab-1/ GM-Tg-cynog-T64242-Ab-2; GM-Tg-felg-T64242-Ab-1/ GM-Tg-felg-T64242-Ab-2; GM-Tg-cang-T64242-Ab-1/ GM-Tg-cang-T64242-Ab-2; GM-Tg-bovg-T64242-Ab-1/ GM-Tg-bovg-T64242-Ab-2; GM-Tg-equg-T64242-Ab-1/ GM-Tg-equg-T64242-Ab-2 |
| Products Name | Anti-CYP46A1 monoclonal antibody |
| Format | mab |
| Target Name | CYP46A1 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-CYP46A1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T64242-Ag-1 | Recombinant multi-species CP46A/ CYP46A1/ CP46 protein |
| ORF Viral Vector | pGMLPm005074 | mouse Cyp46a1 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm005074 | mouse Cyp46a1 Lentivirus particle |
Target information
| Target ID | GM-T64242 |
| Target Name | CYP46A1 |
| Gene ID | 10858,13116,362782,705843,480432,101093112,506438,100051131 |
| Gene Symbol and Synonyms | CH24H,CP46,CYP46,CYP46A1 |
| Uniprot Accession | Q9Y6A2 |
| Uniprot Entry Name | CP46A_HUMAN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000036530 |
| Target Classification | N/A |
The target: CYP46A1, gene name: CYP46A1, also named as CP46, CYP46. This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein is expressed in the brain, where it converts cholesterol to 24S-hydroxycholesterol. While cholesterol cannot pass the blood-brain barrier, 24S-hydroxycholesterol can be secreted in the brain into the circulation to be returned to the liver for catabolism. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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