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Anti-5HT3A/ HTR3A/ 5-HT-3 monoclonal antibody
Anti-5HT3A/ HTR3A/ 5-HT-3 antibody for FACS & in-vivo assay
Go to HTR3A/HTR3A products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T64591-Ab-1/ GM-Tg-hg-T64591-Ab-2 | Anti-Human HTR3A monoclonal antibody | Human |
| GM-Tg-rg-T64591-Ab-1/ GM-Tg-rg-T64591-Ab-2 | Anti-Rat HTR3A monoclonal antibody | Rat |
| GM-Tg-mg-T64591-Ab-1/ GM-Tg-mg-T64591-Ab-2 | Anti-Mouse HTR3A monoclonal antibody | Mouse |
| GM-Tg-cynog-T64591-Ab-1/ GM-Tg-cynog-T64591-Ab-2 | Anti-Cynomolgus/ Rhesus macaque HTR3A monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T64591-Ab-1/ GM-Tg-felg-T64591-Ab-2 | Anti-Feline HTR3A monoclonal antibody | Feline |
| GM-Tg-cang-T64591-Ab-1/ GM-Tg-cang-T64591-Ab-2 | Anti-Canine HTR3A monoclonal antibody | Canine |
| GM-Tg-bovg-T64591-Ab-1/ GM-Tg-bovg-T64591-Ab-2 | Anti-Bovine HTR3A monoclonal antibody | Bovine |
| GM-Tg-equg-T64591-Ab-1/ GM-Tg-equg-T64591-Ab-2 | Anti-Equine HTR3A monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T64591-Ab-1/ GM-Tg-hg-T64591-Ab-2; GM-Tg-rg-T64591-Ab-1/ GM-Tg-rg-T64591-Ab-2; GM-Tg-mg-T64591-Ab-1/ GM-Tg-mg-T64591-Ab-2; GM-Tg-cynog-T64591-Ab-1/ GM-Tg-cynog-T64591-Ab-2; GM-Tg-felg-T64591-Ab-1/ GM-Tg-felg-T64591-Ab-2; GM-Tg-cang-T64591-Ab-1/ GM-Tg-cang-T64591-Ab-2; GM-Tg-bovg-T64591-Ab-1/ GM-Tg-bovg-T64591-Ab-2; GM-Tg-equg-T64591-Ab-1/ GM-Tg-equg-T64591-Ab-2 |
| Products Name | Anti-HTR3A monoclonal antibody |
| Format | mab |
| Target Name | HTR3A |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-HTR3A benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species 5HT3A/ HTR3A/ 5-HT-3 VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | pGMLP002898 | human HTR3A Lentivirus plasmid |
| ORF Viral Vector | vGMLP002898 | human HTR3A Lentivirus particle |
| ORF Viral Vector | pGMLPm004366 | mouse Htr3a Lentivirus plasmid |
| ORF Viral Vector | vGMLPm004366 | mouse Htr3a Lentivirus particle |
Target information
| Target ID | GM-T64591 |
| Target Name | HTR3A |
| Gene ID | 3359,15561,79246,696912,489399,101098004,617674,100009690 |
| Gene Symbol and Synonyms | 5-HT-3,5-HT3,5-HT3A,5-HT3R,5HT3,5HT3R,HTR3,HTR3A |
| Uniprot Accession | P46098,P35563 |
| Uniprot Entry Name | 5HT3A_HUMAN,5HT3A_RAT |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000166736 |
| Target Classification | N/A |
The target: HTR3A, gene name: HTR3A, also named as 5-HT-3, 5-HT3A, 5-HT3R, 5HT3R, HTR3. The product of this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit A of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor causes fast, depolarizing responses in neurons after activation. It appears that the heteromeric combination of A and B subunits is necessary to provide the full functional features of this receptor, since either subunit alone results in receptors with very low conductance and response amplitude. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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