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Anti-HRH3/ H3R/ GPCR97 monoclonal antibody
Anti-HRH3/ H3R/ GPCR97 antibody for FACS & in-vivo assay
Go to H3R/HRH3 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T64765-Ab-1/ GM-Tg-hg-T64765-Ab-2 | Anti-Human H3R/HRH3 monoclonal antibody | Human |
| GM-Tg-rg-T64765-Ab-1/ GM-Tg-rg-T64765-Ab-2 | Anti-Rat H3R/HRH3 monoclonal antibody | Rat |
| GM-Tg-mg-T64765-Ab-1/ GM-Tg-mg-T64765-Ab-2 | Anti-Mouse H3R/HRH3 monoclonal antibody | Mouse |
| GM-Tg-cynog-T64765-Ab-1/ GM-Tg-cynog-T64765-Ab-2 | Anti-Cynomolgus/ Rhesus macaque H3R/HRH3 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T64765-Ab-1/ GM-Tg-felg-T64765-Ab-2 | Anti-Feline H3R/HRH3 monoclonal antibody | Feline |
| GM-Tg-cang-T64765-Ab-1/ GM-Tg-cang-T64765-Ab-2 | Anti-Canine H3R/HRH3 monoclonal antibody | Canine |
| GM-Tg-bovg-T64765-Ab-1/ GM-Tg-bovg-T64765-Ab-2 | Anti-Bovine H3R/HRH3 monoclonal antibody | Bovine |
| GM-Tg-equg-T64765-Ab-1/ GM-Tg-equg-T64765-Ab-2 | Anti-Equine H3R/HRH3 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T64765-Ab-1/ GM-Tg-hg-T64765-Ab-2; GM-Tg-rg-T64765-Ab-1/ GM-Tg-rg-T64765-Ab-2; GM-Tg-mg-T64765-Ab-1/ GM-Tg-mg-T64765-Ab-2; GM-Tg-cynog-T64765-Ab-1/ GM-Tg-cynog-T64765-Ab-2; GM-Tg-felg-T64765-Ab-1/ GM-Tg-felg-T64765-Ab-2; GM-Tg-cang-T64765-Ab-1/ GM-Tg-cang-T64765-Ab-2; GM-Tg-bovg-T64765-Ab-1/ GM-Tg-bovg-T64765-Ab-2; GM-Tg-equg-T64765-Ab-1/ GM-Tg-equg-T64765-Ab-2 |
| Products Name | Anti-H3R/HRH3 monoclonal antibody |
| Format | mab |
| Target Name | H3R |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-H3R benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species HRH3/ H3R/ GPCR97 VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | vGMLP003707 | human HRH3 Lentivirus particle |
| ORF Viral Vector | pGMLP003707 | human HRH3 Lentivirus plasmid |
Target information
| Target ID | GM-T64765 |
| Target Name | H3R |
| Gene ID | 11255,99296,85268,574253,477282,105260416,789851,100058016 |
| Gene Symbol and Synonyms | Eae8,GPCR97,H3R,HH3R,HRH3 |
| Uniprot Accession | Q9Y5N1,Q9QYN8 |
| Uniprot Entry Name | HRH3_HUMAN,HRH3_RAT |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000101180 |
| Target Classification | GPCR |
The target: H3R, gene name: HRH3, also named as GPCR97, HH3R. Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. This gene encodes one of the histamine receptors (H3) which belongs to the family 1 of G protein-coupled receptors. It is an integral membrane protein and can regulate neurotransmitter release. This receptor can also increase voltage-dependent calcium current in smooth muscles and innervates the blood vessels and the heart in cardiovascular system. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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