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Anti-CAC1G/ CACNA1G/ Ca(V)T.1 monoclonal antibody
Anti-CAC1G/ CACNA1G/ Ca(V)T.1 antibody for FACS & in-vivo assay
Go to CACNA1G/CACNA1G products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T64795-Ab-1/ GM-Tg-hg-T64795-Ab-2 | Anti-Human CACNA1G monoclonal antibody | Human |
| GM-Tg-rg-T64795-Ab-1/ GM-Tg-rg-T64795-Ab-2 | Anti-Rat CACNA1G monoclonal antibody | Rat |
| GM-Tg-mg-T64795-Ab-1/ GM-Tg-mg-T64795-Ab-2 | Anti-Mouse CACNA1G monoclonal antibody | Mouse |
| GM-Tg-cynog-T64795-Ab-1/ GM-Tg-cynog-T64795-Ab-2 | Anti-Cynomolgus/ Rhesus macaque CACNA1G monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T64795-Ab-1/ GM-Tg-felg-T64795-Ab-2 | Anti-Feline CACNA1G monoclonal antibody | Feline |
| GM-Tg-cang-T64795-Ab-1/ GM-Tg-cang-T64795-Ab-2 | Anti-Canine CACNA1G monoclonal antibody | Canine |
| GM-Tg-bovg-T64795-Ab-1/ GM-Tg-bovg-T64795-Ab-2 | Anti-Bovine CACNA1G monoclonal antibody | Bovine |
| GM-Tg-equg-T64795-Ab-1/ GM-Tg-equg-T64795-Ab-2 | Anti-Equine CACNA1G monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T64795-Ab-1/ GM-Tg-hg-T64795-Ab-2; GM-Tg-rg-T64795-Ab-1/ GM-Tg-rg-T64795-Ab-2; GM-Tg-mg-T64795-Ab-1/ GM-Tg-mg-T64795-Ab-2; GM-Tg-cynog-T64795-Ab-1/ GM-Tg-cynog-T64795-Ab-2; GM-Tg-felg-T64795-Ab-1/ GM-Tg-felg-T64795-Ab-2; GM-Tg-cang-T64795-Ab-1/ GM-Tg-cang-T64795-Ab-2; GM-Tg-bovg-T64795-Ab-1/ GM-Tg-bovg-T64795-Ab-2; GM-Tg-equg-T64795-Ab-1/ GM-Tg-equg-T64795-Ab-2 |
| Products Name | Anti-CACNA1G monoclonal antibody |
| Format | mab |
| Target Name | CACNA1G |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-CACNA1G benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species CAC1G/ CACNA1G/ Ca(V)T.1 VLP (virus-like particle) (Products Developing) |
Target information
| Target ID | GM-T64795 |
| Target Name | CACNA1G |
| Gene ID | 8913,12291,29717,706230,491083,101098757,282411,100070000 |
| Gene Symbol and Synonyms | a1G,alpha-1G,Ca(v)3.1,Ca(V)T.1,CACNA1G,Cav3.1,Cav3.1d,mKIAA1123,NBR13,SCA42,SCA42ND,[a]1G |
| Uniprot Accession | O43497,O54898 |
| Uniprot Entry Name | CAC1G_HUMAN,CAC1G_RAT |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target |
| Disease | Cancer |
| Gene Ensembl | ENSG00000006283 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: CACNA1G, gene name: CACNA1G, also named as Ca(V)T.1, Cav3.1, NBR13, SCA42, SCA42ND. Voltage-sensitive calcium channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division, and cell death. This gene encodes a T-type, low-voltage activated calcium channel. The T-type channels generate currents that are both transient, owing to fast inactivation, and tiny, owing to small conductance. T-type channels are thought to be involved in pacemaker activity, low-threshold calcium spikes, neuronal oscillations and resonance, and rebound burst firing. Many alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Sep 2011].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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