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Anti-PGH2/ COX-2/ PTGS2 functional antibody
Anti-PGH2/ COX-2/ PTGS2 functional antibody for cell culture, ELISA & in-vivo assay
Go to COX-2/PTGS2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T66665-Ab-1/ GM-Tg-hg-T66665-Ab-2 | Anti-Human COX-2/PTGS2 monoclonal antibody | Human |
| GM-Tg-rg-T66665-Ab-1/ GM-Tg-rg-T66665-Ab-2 | Anti-Rat COX-2/PTGS2 monoclonal antibody | Rat |
| GM-Tg-mg-T66665-Ab-1/ GM-Tg-mg-T66665-Ab-2 | Anti-Mouse COX-2/PTGS2 monoclonal antibody | Mouse |
| GM-Tg-cynog-T66665-Ab-1/ GM-Tg-cynog-T66665-Ab-2 | Anti-Cynomolgus/ Rhesus macaque COX-2/PTGS2 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T66665-Ab-1/ GM-Tg-felg-T66665-Ab-2 | Anti-Feline COX-2/PTGS2 monoclonal antibody | Feline |
| GM-Tg-cang-T66665-Ab-1/ GM-Tg-cang-T66665-Ab-2 | Anti-Canine COX-2/PTGS2 monoclonal antibody | Canine |
| GM-Tg-bovg-T66665-Ab-1/ GM-Tg-bovg-T66665-Ab-2 | Anti-Bovine COX-2/PTGS2 monoclonal antibody | Bovine |
| GM-Tg-equg-T66665-Ab-1/ GM-Tg-equg-T66665-Ab-2 | Anti-Equine COX-2/PTGS2 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T66665-Ab-1/ GM-Tg-hg-T66665-Ab-2; GM-Tg-rg-T66665-Ab-1/ GM-Tg-rg-T66665-Ab-2; GM-Tg-mg-T66665-Ab-1/ GM-Tg-mg-T66665-Ab-2; GM-Tg-cynog-T66665-Ab-1/ GM-Tg-cynog-T66665-Ab-2; GM-Tg-felg-T66665-Ab-1/ GM-Tg-felg-T66665-Ab-2; GM-Tg-cang-T66665-Ab-1/ GM-Tg-cang-T66665-Ab-2; GM-Tg-bovg-T66665-Ab-1/ GM-Tg-bovg-T66665-Ab-2; GM-Tg-equg-T66665-Ab-1/ GM-Tg-equg-T66665-Ab-2 |
| Products Name | Anti-COX-2/PTGS2 monoclonal antibody |
| Format | mab |
| Target Name | COX-2 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-COX-2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T66665-Ag-1 | Recombinant multi-species PGH2/ COX-2/ PTGS2 protein |
| ORF Viral Vector | vGMAP000471 | Human PTGS2 Adenovirus particle |
| ORF Viral Vector | pGMAP000471 | Human PTGS2 Adenovirus plasmid |
| ORF Viral Vector | pGMLPm001737 | mouse Ptgs2 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm001737 | mouse Ptgs2 Lentivirus particle |
Target information
| Target ID | GM-T66665 |
| Target Name | COX-2 |
| Gene ID | 5743,19225,29527,716671,442942,100126581,282023,791253 |
| Gene Symbol and Synonyms | COX-2,COX2,GRIPGHS,hCox-2,PES-2,PGG/HS,PGH2S,PGHS-2,Pghs2,PHS II,PHS-2,PTGS2,TIS10 |
| Uniprot Accession | P35354,P35355,O62698,O19183 |
| Uniprot Entry Name | PGH2_HUMAN,PGH2_RAT,PGH2_BOVIN,PGH2_HORSE |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | Therapeutics Target, Immuno-oncology Target |
| Disease | Cancer |
| Gene Ensembl | ENSG00000073756 |
| Target Classification | Checkpoint-Immuno Oncology, Tumor-associated antigen (TAA) |
The target: COX-2, gene name: PTGS2, also named as COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2. Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes the inducible isozyme. It is regulated by specific stimulatory events, suggesting that it is responsible for the prostanoid biosynthesis involved in inflammation and mitogenesis. [provided by RefSeq, Feb 2009].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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