Anti-PTH1R/ PFE/ PTHR monoclonal antibody

Anti-PTH1R/ PFE/ PTHR antibody for FACS & in-vivo assay

Target products collectionGo to PTH1R/PTH1R products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T67710-Ab-1/ GM-Tg-hg-T67710-Ab-2Anti-Human PTH1R monoclonal antibodyHuman
GM-Tg-rg-T67710-Ab-1/ GM-Tg-rg-T67710-Ab-2Anti-Rat PTH1R monoclonal antibodyRat
GM-Tg-mg-T67710-Ab-1/ GM-Tg-mg-T67710-Ab-2Anti-Mouse PTH1R monoclonal antibodyMouse
GM-Tg-cynog-T67710-Ab-1/ GM-Tg-cynog-T67710-Ab-2Anti-Cynomolgus/ Rhesus macaque PTH1R monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T67710-Ab-1/ GM-Tg-felg-T67710-Ab-2Anti-Feline PTH1R monoclonal antibodyFeline
GM-Tg-cang-T67710-Ab-1/ GM-Tg-cang-T67710-Ab-2Anti-Canine PTH1R monoclonal antibodyCanine
GM-Tg-bovg-T67710-Ab-1/ GM-Tg-bovg-T67710-Ab-2Anti-Bovine PTH1R monoclonal antibodyBovine
GM-Tg-equg-T67710-Ab-1/ GM-Tg-equg-T67710-Ab-2Anti-Equine PTH1R monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T67710-Ab-1/ GM-Tg-hg-T67710-Ab-2; GM-Tg-rg-T67710-Ab-1/ GM-Tg-rg-T67710-Ab-2;
GM-Tg-mg-T67710-Ab-1/ GM-Tg-mg-T67710-Ab-2; GM-Tg-cynog-T67710-Ab-1/ GM-Tg-cynog-T67710-Ab-2;
GM-Tg-felg-T67710-Ab-1/ GM-Tg-felg-T67710-Ab-2; GM-Tg-cang-T67710-Ab-1/ GM-Tg-cang-T67710-Ab-2;
GM-Tg-bovg-T67710-Ab-1/ GM-Tg-bovg-T67710-Ab-2; GM-Tg-equg-T67710-Ab-1/ GM-Tg-equg-T67710-Ab-2
Products NameAnti-PTH1R monoclonal antibody
Formatmab
Target NamePTH1R
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-PTH1R benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species PTH1R/ PFE/ PTHR VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-T67710
    Target NamePTH1R
    Gene ID5745,19228,56813,712147,403779,101095960,507783,100054278
    Gene Symbol and SynonymsEKNS,PFE,PPR,PTH1,PTH1R,PTHR,PTHR1,PTHrel
    Uniprot AccessionQ03431,P25961,Q9TU31,Q1LZF7
    Uniprot Entry NamePTH1R_HUMAN,PTH1R_RAT,PTH1R_CANLF,PTH1R_BOVIN
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target
    DiseaseN/A
    Gene EnsemblENSG00000160801
    Target ClassificationGPCR

    The target: PTH1R, gene name: PTH1R, also named as PFE, PTHR, PTHR1. The protein encoded by this gene is a member of the G-protein coupled receptor family 2. This protein is a receptor for parathyroid hormone (PTH) and for parathyroid hormone-like hormone (PTHLH). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system. Defects in this receptor are known to be the cause of Jansen's metaphyseal chondrodysplasia (JMC), chondrodysplasia Blomstrand type (BOCD), as well as enchodromatosis. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, May 2010].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.