Anti-OX2R/ HCRTR2 monoclonal antibody

Anti-OX2R/ HCRTR2 antibody for FACS & in-vivo assay

Target products collectionGo to HCRTR2/HCRTR2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T69485-Ab-1/ GM-Tg-hg-T69485-Ab-2Anti-Human HCRTR2 monoclonal antibodyHuman
GM-Tg-rg-T69485-Ab-1/ GM-Tg-rg-T69485-Ab-2Anti-Rat HCRTR2 monoclonal antibodyRat
GM-Tg-mg-T69485-Ab-1/ GM-Tg-mg-T69485-Ab-2Anti-Mouse HCRTR2 monoclonal antibodyMouse
GM-Tg-cynog-T69485-Ab-1/ GM-Tg-cynog-T69485-Ab-2Anti-Cynomolgus/ Rhesus macaque HCRTR2 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T69485-Ab-1/ GM-Tg-felg-T69485-Ab-2Anti-Feline HCRTR2 monoclonal antibodyFeline
GM-Tg-cang-T69485-Ab-1/ GM-Tg-cang-T69485-Ab-2Anti-Canine HCRTR2 monoclonal antibodyCanine
GM-Tg-bovg-T69485-Ab-1/ GM-Tg-bovg-T69485-Ab-2Anti-Bovine HCRTR2 monoclonal antibodyBovine
GM-Tg-equg-T69485-Ab-1/ GM-Tg-equg-T69485-Ab-2Anti-Equine HCRTR2 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T69485-Ab-1/ GM-Tg-hg-T69485-Ab-2; GM-Tg-rg-T69485-Ab-1/ GM-Tg-rg-T69485-Ab-2;
GM-Tg-mg-T69485-Ab-1/ GM-Tg-mg-T69485-Ab-2; GM-Tg-cynog-T69485-Ab-1/ GM-Tg-cynog-T69485-Ab-2;
GM-Tg-felg-T69485-Ab-1/ GM-Tg-felg-T69485-Ab-2; GM-Tg-cang-T69485-Ab-1/ GM-Tg-cang-T69485-Ab-2;
GM-Tg-bovg-T69485-Ab-1/ GM-Tg-bovg-T69485-Ab-2; GM-Tg-equg-T69485-Ab-1/ GM-Tg-equg-T69485-Ab-2
Products NameAnti-HCRTR2 monoclonal antibody
Formatmab
Target NameHCRTR2
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-HCRTR2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species OX2R/ HCRTR2 VLP (virus-like particle) (Products Developing)
    ORF Viral VectorpGMLPm002545mouse Hcrtr2 Lentivirus plasmid
    ORF Viral VectorvGMLPm002545mouse Hcrtr2 Lentivirus particle


    Target information

    Target IDGM-T69485
    Target NameHCRTR2
    Gene ID3062,387285,25605,711662,399545,101088488,529603,100056772
    Gene Symbol and SynonymsHCRTR2,mOX2aR,mOX2bR,mOXR2,ORXR2,ox-2-R,ox2-R,OX2aR,OX2bR,OX2R,OXR2
    Uniprot AccessionO43614,P56719,Q9TUP7
    Uniprot Entry NameOX2R_HUMAN,OX2R_RAT,OX2R_CANLF
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target
    DiseaseN/A
    Gene EnsemblENSG00000137252
    Target ClassificationGPCR

    The target: HCRTR2, gene name: HCRTR2, also named as OX2R. The protein encoded by this gene is a G-protein coupled receptor involved in the regulation of feeding behavior. The encoded protein binds the hypothalamic neuropeptides orexin A and orexin B. A related gene (HCRTR1) encodes a G-protein coupled receptor that selectively binds orexin A. [provided by RefSeq, Jan 2009].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.