Anti-OX2R/ HCRTR2 monoclonal antibody
Anti-OX2R/ HCRTR2 antibody for FACS & in-vivo assay
Go to HCRTR2/HCRTR2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
Product information
Catalog No. | Product Name | Species Reactivity |
---|---|---|
GM-Tg-hg-T69485-Ab-1/ GM-Tg-hg-T69485-Ab-2 | Anti-Human HCRTR2 monoclonal antibody | Human |
GM-Tg-rg-T69485-Ab-1/ GM-Tg-rg-T69485-Ab-2 | Anti-Rat HCRTR2 monoclonal antibody | Rat |
GM-Tg-mg-T69485-Ab-1/ GM-Tg-mg-T69485-Ab-2 | Anti-Mouse HCRTR2 monoclonal antibody | Mouse |
GM-Tg-cynog-T69485-Ab-1/ GM-Tg-cynog-T69485-Ab-2 | Anti-Cynomolgus/ Rhesus macaque HCRTR2 monoclonal antibody | Cynomolgus/ Rhesus macaque |
GM-Tg-felg-T69485-Ab-1/ GM-Tg-felg-T69485-Ab-2 | Anti-Feline HCRTR2 monoclonal antibody | Feline |
GM-Tg-cang-T69485-Ab-1/ GM-Tg-cang-T69485-Ab-2 | Anti-Canine HCRTR2 monoclonal antibody | Canine |
GM-Tg-bovg-T69485-Ab-1/ GM-Tg-bovg-T69485-Ab-2 | Anti-Bovine HCRTR2 monoclonal antibody | Bovine |
GM-Tg-equg-T69485-Ab-1/ GM-Tg-equg-T69485-Ab-2 | Anti-Equine HCRTR2 monoclonal antibody | Equine |
Size: 1mg | 10mg | 100mg
Product Description
Catalog No. | GM-Tg-hg-T69485-Ab-1/ GM-Tg-hg-T69485-Ab-2; GM-Tg-rg-T69485-Ab-1/ GM-Tg-rg-T69485-Ab-2; GM-Tg-mg-T69485-Ab-1/ GM-Tg-mg-T69485-Ab-2; GM-Tg-cynog-T69485-Ab-1/ GM-Tg-cynog-T69485-Ab-2; GM-Tg-felg-T69485-Ab-1/ GM-Tg-felg-T69485-Ab-2; GM-Tg-cang-T69485-Ab-1/ GM-Tg-cang-T69485-Ab-2; GM-Tg-bovg-T69485-Ab-1/ GM-Tg-bovg-T69485-Ab-2; GM-Tg-equg-T69485-Ab-1/ GM-Tg-equg-T69485-Ab-2 |
Products Name | Anti-HCRTR2 monoclonal antibody |
Format | mab |
Target Name | HCRTR2 |
Protein Sub-location | Transmembrane Protein |
Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
Derivation (species) | Mouse |
CH1+2+3 Isotype (Receptor identification) | IgG |
Type of Light Chain (VD-LC) | N/A |
Expression platform | Mammalian Expression |
Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
Tag | Fc |
Products description | Pre-made anti-HCRTR2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
Purity | Purity: ≥95% (SDS-PAGE) |
Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
Category | Cat No. | Products Name |
Target Antigen | Products Developing | Multi-species OX2R/ HCRTR2 VLP (virus-like particle) (Products Developing) |
ORF Viral Vector | pGMLPm002545 | mouse Hcrtr2 Lentivirus plasmid |
ORF Viral Vector | vGMLPm002545 | mouse Hcrtr2 Lentivirus particle |
Target information
Target ID | GM-T69485 |
Target Name | HCRTR2 |
Gene ID | 3062,387285,25605,711662,399545,101088488,529603,100056772 |
Gene Symbol and Synonyms | HCRTR2,mOX2aR,mOX2bR,mOXR2,ORXR2,ox-2-R,ox2-R,OX2aR,OX2bR,OX2R,OXR2 |
Uniprot Accession | O43614,P56719,Q9TUP7 |
Uniprot Entry Name | OX2R_HUMAN,OX2R_RAT,OX2R_CANLF |
Protein Sub-location | Transmembrane Protein |
Category | Therapeutics Target |
Disease | N/A |
Gene Ensembl | ENSG00000137252 |
Target Classification | GPCR |
The target: HCRTR2, gene name: HCRTR2, also named as OX2R. The protein encoded by this gene is a G-protein coupled receptor involved in the regulation of feeding behavior. The encoded protein binds the hypothalamic neuropeptides orexin A and orexin B. A related gene (HCRTR1) encodes a G-protein coupled receptor that selectively binds orexin A. [provided by RefSeq, Jan 2009].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.