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Anti-AOC3/ HPAO/ SSAO monoclonal antibody
Anti-AOC3/ HPAO/ SSAO antibody for FACS & in-vivo assay
Go to AOC3/AOC3 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T69619-Ab-1/ GM-Tg-hg-T69619-Ab-2 | Anti-Human AOC3 monoclonal antibody | Human |
| GM-Tg-rg-T69619-Ab-1/ GM-Tg-rg-T69619-Ab-2 | Anti-Rat AOC3 monoclonal antibody | Rat |
| GM-Tg-mg-T69619-Ab-1/ GM-Tg-mg-T69619-Ab-2 | Anti-Mouse AOC3 monoclonal antibody | Mouse |
| GM-Tg-cynog-T69619-Ab-1/ GM-Tg-cynog-T69619-Ab-2 | Anti-Cynomolgus/ Rhesus macaque AOC3 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T69619-Ab-1/ GM-Tg-felg-T69619-Ab-2 | Anti-Feline AOC3 monoclonal antibody | Feline |
| GM-Tg-cang-T69619-Ab-1/ GM-Tg-cang-T69619-Ab-2 | Anti-Canine AOC3 monoclonal antibody | Canine |
| GM-Tg-bovg-T69619-Ab-1/ GM-Tg-bovg-T69619-Ab-2 | Anti-Bovine AOC3 monoclonal antibody | Bovine |
| GM-Tg-equg-T69619-Ab-1/ GM-Tg-equg-T69619-Ab-2 | Anti-Equine AOC3 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T69619-Ab-1/ GM-Tg-hg-T69619-Ab-2; GM-Tg-rg-T69619-Ab-1/ GM-Tg-rg-T69619-Ab-2; GM-Tg-mg-T69619-Ab-1/ GM-Tg-mg-T69619-Ab-2; GM-Tg-cynog-T69619-Ab-1/ GM-Tg-cynog-T69619-Ab-2; GM-Tg-felg-T69619-Ab-1/ GM-Tg-felg-T69619-Ab-2; GM-Tg-cang-T69619-Ab-1/ GM-Tg-cang-T69619-Ab-2; GM-Tg-bovg-T69619-Ab-1/ GM-Tg-bovg-T69619-Ab-2; GM-Tg-equg-T69619-Ab-1/ GM-Tg-equg-T69619-Ab-2 |
| Products Name | Anti-AOC3 monoclonal antibody |
| Format | mab |
| Target Name | AOC3 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-AOC3 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Biosimilar | GMP-Bios-ab-577 | Pre-Made Timolumab biosimilar, Whole mAb, Anti-AOC3 Antibody: Anti-HPAO/SSAO/VAP-1/VAP1 therapeutic antibody |
| Biosimilar | GMP-Bios-INN-1047 | Pre-Made Vepalimomab Biosimilar, Whole Mab, Anti-Aoc3 Antibody: Anti-HPAO/SSAO/VAP-1/VAP1 therapeutic antibody |
| Biosimilar | GMP-Bios-INN-1046 | Pre-Made Vapaliximab Biosimilar, Whole Mab, Anti-Aoc3 Antibody: Anti-HPAO/SSAO/VAP-1/VAP1 therapeutic antibody |
| Target Antigen | Products Developing | Multi-species AOC3/ HPAO/ SSAO VLP (virus-like particle) (Products Developing) |
Target information
| Target ID | GM-T69619 |
| Target Name | AOC3 |
| Gene ID | 8639,11754,480511,123378914,281002,100065767 |
| Gene Symbol and Synonyms | AOC3,BOLAO,HPAO,SSAO,VAP-1,VAP1 |
| Uniprot Accession | Q16853,O46406 |
| Uniprot Entry Name | AOC3_HUMAN,AOCY_BOVIN |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target, INN Index |
| Disease | N/A |
| Gene Ensembl | ENSG00000131471 |
| Target Classification | N/A |
The target: AOC3, gene name: AOC3, also named as HPAO, SSAO, VAP-1, VAP1. This gene encodes a member of the semicarbazide-sensitive amine oxidase family. Copper amine oxidases catalyze the oxidative conversion of amines to aldehydes in the presence of copper and quinone cofactor. The encoded protein is localized to the cell surface, has adhesive properties as well as monoamine oxidase activity, and may be involved in leukocyte trafficking. Alterations in levels of the encoded protein may be associated with many diseases, including diabetes mellitus. A pseudogene of this gene has been described and is located approximately 9-kb downstream on the same chromosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2013].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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