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Anti-CLTR1/ CYSLTR1/ CYSLT1 monoclonal antibody
Anti-CLTR1/ CYSLTR1/ CYSLT1 antibody for FACS & in-vivo assay
Go to CYSLTR1/CYSLTR1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T71192-Ab-1/ GM-Tg-hg-T71192-Ab-2 | Anti-Human CYSLTR1 monoclonal antibody | Human |
| GM-Tg-rg-T71192-Ab-1/ GM-Tg-rg-T71192-Ab-2 | Anti-Rat CYSLTR1 monoclonal antibody | Rat |
| GM-Tg-mg-T71192-Ab-1/ GM-Tg-mg-T71192-Ab-2 | Anti-Mouse CYSLTR1 monoclonal antibody | Mouse |
| GM-Tg-cynog-T71192-Ab-1/ GM-Tg-cynog-T71192-Ab-2 | Anti-Cynomolgus/ Rhesus macaque CYSLTR1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T71192-Ab-1/ GM-Tg-felg-T71192-Ab-2 | Anti-Feline CYSLTR1 monoclonal antibody | Feline |
| GM-Tg-cang-T71192-Ab-1/ GM-Tg-cang-T71192-Ab-2 | Anti-Canine CYSLTR1 monoclonal antibody | Canine |
| GM-Tg-bovg-T71192-Ab-1/ GM-Tg-bovg-T71192-Ab-2 | Anti-Bovine CYSLTR1 monoclonal antibody | Bovine |
| GM-Tg-equg-T71192-Ab-1/ GM-Tg-equg-T71192-Ab-2 | Anti-Equine CYSLTR1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T71192-Ab-1/ GM-Tg-hg-T71192-Ab-2; GM-Tg-rg-T71192-Ab-1/ GM-Tg-rg-T71192-Ab-2; GM-Tg-mg-T71192-Ab-1/ GM-Tg-mg-T71192-Ab-2; GM-Tg-cynog-T71192-Ab-1/ GM-Tg-cynog-T71192-Ab-2; GM-Tg-felg-T71192-Ab-1/ GM-Tg-felg-T71192-Ab-2; GM-Tg-cang-T71192-Ab-1/ GM-Tg-cang-T71192-Ab-2; GM-Tg-bovg-T71192-Ab-1/ GM-Tg-bovg-T71192-Ab-2; GM-Tg-equg-T71192-Ab-1/ GM-Tg-equg-T71192-Ab-2 |
| Products Name | Anti-CYSLTR1 monoclonal antibody |
| Format | mab |
| Target Name | CYSLTR1 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-CYSLTR1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species CLTR1/ CYSLTR1/ CYSLT1 VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | pGMLPm003467 | mouse Cysltr1 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm003467 | mouse Cysltr1 Lentivirus particle |
Target information
| Target ID | GM-T71192 |
| Target Name | CYSLTR1 |
| Gene ID | 10800,58861,114099,706663,100686426,101087714,782045,100072636 |
| Gene Symbol and Synonyms | CYSLT1,CYSLT1R,CYSLTR,CYSLTR1,HM™F81 |
| Uniprot Accession | Q9Y271,Q924T8 |
| Uniprot Entry Name | CLTR1_HUMAN,CLTR1_RAT |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000173198 |
| Target Classification | N/A |
The target: CYSLTR1, gene name: CYSLTR1, also named as CYSLT1, CYSLT1R, CYSLTR, HM™F81. This gene encodes a member of the G-protein coupled receptor 1 family. The encoded protein is a receptor for cysteinyl leukotrienes, and is involved in mediating bronchoconstriction via activation of a phosphatidylinositol-calcium second messenger system. Activation of the encoded receptor results in contraction and proliferation of bronchial smooth muscle cells, eosinophil migration, and damage to the mucus layer in the lung. Upregulation of this gene is associated with asthma and dysregulation may also be implicated in cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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