Anti-CLTR1/ CYSLTR1/ CYSLT1 monoclonal antibody

Anti-CLTR1/ CYSLTR1/ CYSLT1 antibody for FACS & in-vivo assay

Target products collectionGo to CYSLTR1/CYSLTR1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T71192-Ab-1/ GM-Tg-hg-T71192-Ab-2Anti-Human CYSLTR1 monoclonal antibodyHuman
GM-Tg-rg-T71192-Ab-1/ GM-Tg-rg-T71192-Ab-2Anti-Rat CYSLTR1 monoclonal antibodyRat
GM-Tg-mg-T71192-Ab-1/ GM-Tg-mg-T71192-Ab-2Anti-Mouse CYSLTR1 monoclonal antibodyMouse
GM-Tg-cynog-T71192-Ab-1/ GM-Tg-cynog-T71192-Ab-2Anti-Cynomolgus/ Rhesus macaque CYSLTR1 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T71192-Ab-1/ GM-Tg-felg-T71192-Ab-2Anti-Feline CYSLTR1 monoclonal antibodyFeline
GM-Tg-cang-T71192-Ab-1/ GM-Tg-cang-T71192-Ab-2Anti-Canine CYSLTR1 monoclonal antibodyCanine
GM-Tg-bovg-T71192-Ab-1/ GM-Tg-bovg-T71192-Ab-2Anti-Bovine CYSLTR1 monoclonal antibodyBovine
GM-Tg-equg-T71192-Ab-1/ GM-Tg-equg-T71192-Ab-2Anti-Equine CYSLTR1 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T71192-Ab-1/ GM-Tg-hg-T71192-Ab-2; GM-Tg-rg-T71192-Ab-1/ GM-Tg-rg-T71192-Ab-2;
GM-Tg-mg-T71192-Ab-1/ GM-Tg-mg-T71192-Ab-2; GM-Tg-cynog-T71192-Ab-1/ GM-Tg-cynog-T71192-Ab-2;
GM-Tg-felg-T71192-Ab-1/ GM-Tg-felg-T71192-Ab-2; GM-Tg-cang-T71192-Ab-1/ GM-Tg-cang-T71192-Ab-2;
GM-Tg-bovg-T71192-Ab-1/ GM-Tg-bovg-T71192-Ab-2; GM-Tg-equg-T71192-Ab-1/ GM-Tg-equg-T71192-Ab-2
Products NameAnti-CYSLTR1 monoclonal antibody
Formatmab
Target NameCYSLTR1
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-CYSLTR1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species CLTR1/ CYSLTR1/ CYSLT1 VLP (virus-like particle) (Products Developing)
    ORF Viral VectorpGMLPm003467mouse Cysltr1 Lentivirus plasmid
    ORF Viral VectorvGMLPm003467mouse Cysltr1 Lentivirus particle


    Target information

    Target IDGM-T71192
    Target NameCYSLTR1
    Gene ID10800,58861,114099,706663,100686426,101087714,782045,100072636
    Gene Symbol and SynonymsCYSLT1,CYSLT1R,CYSLTR,CYSLTR1,HM™F81
    Uniprot AccessionQ9Y271,Q924T8
    Uniprot Entry NameCLTR1_HUMAN,CLTR1_RAT
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target
    DiseaseN/A
    Gene EnsemblENSG00000173198
    Target ClassificationN/A

    The target: CYSLTR1, gene name: CYSLTR1, also named as CYSLT1, CYSLT1R, CYSLTR, HM™F81. This gene encodes a member of the G-protein coupled receptor 1 family. The encoded protein is a receptor for cysteinyl leukotrienes, and is involved in mediating bronchoconstriction via activation of a phosphatidylinositol-calcium second messenger system. Activation of the encoded receptor results in contraction and proliferation of bronchial smooth muscle cells, eosinophil migration, and damage to the mucus layer in the lung. Upregulation of this gene is associated with asthma and dysregulation may also be implicated in cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.